Prognostic Factors of Patients With ADHF

Elevated Blood Monocyte Count Predicts 1 Year Poor Outcomes for Patients Admitted With Acute Decompensated Heart Failure

To explore the prognostic indicators for patients with ADHF

Study Overview

• Status: Completed
• Conditions: Acute Decompensated Heart Failure
• Intervention / Treatment: Other: elevated monocyte count

Detailed Description

According to ESC Guidelines for the diagnosis of acute heart failure 2008, patients with ADHF were diagnosed, and their medical history, laboratory examination and treatment plan were retrospectively analyzed, and the patients were followed up for 1 year. The 1-year outcomes of patients were analyzed to explore the prognostic indicators for patients with ADHF

• Study Type: Observational
• Enrollment (Actual): 362

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 94 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

ADHF patient diagnosed in the department of cardiovascular medicine in the first affiliated hospital of chongqing medical university

Description

Inclusion Criteria:

• Patients with ADHF diagnosed according to ESC Guidelines for the diagnosis of acute heart failure 2008

Exclusion Criteria:

• disorders of the hematopoietic system, history of cancer and/or previous treatment with chemotherapy, the infection caused by various pathogens, chronic inflammatory conditions, glucocorticoid therapy and/or histories of glucocorticoid use 3 months before the admission and acute myocardial infarction or coronary revascularization within the past 6 months. Also, patients who did not have a differential WBC count or who were lost to follow-up were excluded.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
high group; high group: monocyte count≥0.445×10*9 cells/L	Other: elevated monocyte count; The monocyte count at admission was higher than 0.445×10*9 cells/L
low group; low group: monocyte count<0.445×10*9 cells/L;

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
all-cause death	The primary end point was one-year all-cause death	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
HF-related rehospitalization	the secondary end point was one-year HF-related rehospitalization.	1 year

Collaborators and Investigators

• Sponsor: Chongqing Medical University

Study record dates

Study Major Dates

• Study Start (Actual): August 2, 2011
• Primary Completion (Actual): February 16, 2015
• Study Completion (Actual): February 16, 2015

Study Registration Dates

• First Submitted: May 4, 2020
• First Submitted That Met QC Criteria: May 13, 2020
• First Posted (Actual): May 18, 2020

Study Record Updates

• Last Update Posted (Actual): May 18, 2020
• Last Update Submitted That Met QC Criteria: May 13, 2020
• Last Verified: May 1, 2020

More Information

Terms related to this study

• Keywords: heart failure; all-cause death; acute decompensated heart failure; monocyte count
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Failure
• Other Study ID Numbers: 2020-05-04

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No