Impact of Additional Resistance Training During Rehabilitation Therapy in Patients With Heart Failure

Impact of Different Types of Resistance Training Additional to Endurance Training During Rehabilitation Therapy in Patients With Heart Failure

The impact of moderate- or low-intensity resistance training will be investigated additional to endurance training in heart failure patients following rehabilitation. The aim is to optimize intensity of resistance training in this patient population.

Study Overview

• Status: Not yet recruiting
• Conditions: Heart Failure
• Intervention / Treatment: Other: Exercise therapy

• Study Type: Interventional
• Enrollment (Anticipated): 30
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Dominique Hansen, Professor; Phone Number: 0032 011 29 21 26; Email: dominique.hansen@uhasselt.be

Study Locations

• Belgium
  • Limburg
    • Genk, Limburg, Belgium, 3600
      • Ziekenhuis Oost-Limburg
      • Contact: Wilfried Mullens, Professor; Phone Number: 0032 089 32 50 50; Email: wilfried.mullens@uhasselt.be
      • Contact: Kristof Gelade, Physiotherapist; Phone Number: 0032 089 32 73 41; Email: kristof.gelade@zol.be

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Diagnosis of heart failure and participation in cardiac rehabilitation

Exclusion Criteria:

• Orthopedic disorders, neurological disorders affecting muscle strength, cognitive disorders, heart or arterial surgery (percutaneous coronary intervention, bypass, heart valve surgery) in the last year, acute myocardial infarction in the last 6 months, participation in another intervention

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: training group 1: low-intensity resistance training	Other: Exercise therapy; 15 weeks of resistance training (additional to endurance training)
Experimental: training group 2: moderate-intensity resistance training	Other: Exercise therapy; 15 weeks of resistance training (additional to endurance training)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
VO2peak	Maximal oxygen consumption during cardiopulmonary exercise test	Prior to the intervention
VO2peak	Maximal oxygen consumption during cardiopulmonary exercise test	After 15 weeks of intervention
VO2peak	Maximal oxygen consumption during cardiopulmonary exercise test	After 24 weeks of follow-up

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle strength	One-repetition maximum test (1RM) to evaluate maximal contraction of the muscle	Prior to the intervention
Muscle strength	One-repetition maximum test (1RM) to evaluate maximal contraction of the muscle	After 15 weeks of intervention
Muscle strength	One-repetition maximum test (1RM) to evaluate maximal contraction of the muscle	After 24 weeks of follow-up
Functional capacity	Functional capacity evaluated via the six-minute walking test	Prior to the intervention
Functional capacity	Functional capacity evaluated via the six-minute walking test	After 15 weeks of intervention
Functional capacity	Functional capacity evaluated via the six-minute walking test	After 24 weeks of follow-up
Quality of life in heart failure patients	Evaluation via Minnesota living with heart failure questionnaire	Prior to the intervention
Quality of life in heart failure patients	Evaluation via Minnesota living with heart failure questionnaire	After 15 weeks of intervention
Quality of life in heart failure patients	Evaluation via Minnesota living with heart failure questionnaire	After 24 weeks of follow-up
Cardiac function	left-ventricular ejection fraction evaluated by transthoracic echocardiography	Prior to the intervention
Cardiac function	left-ventricular ejection fraction evaluated by transthoracic echocardiography	After 15 weeks of intervention
Cardiac function	left-ventricular ejection fraction evaluated by transthoracic echocardiography	After 24 weeks of follow-up
Anthropometric measurements	body weight evaluated to determine body mass index	Prior to the intervention
Anthropometric measurements	body weight evaluated to determine body mass index	After 15 weeks of intervention
Anthropometric measurements	body weight evaluated to determine body mass index	After 24 weeks of follow-up

Collaborators and Investigators

• Sponsor: Hasselt University
• Collaborators: Ziekenhuis Oost-Limburg

Study record dates

Study Major Dates

• Study Start (Anticipated): August 1, 2021
• Primary Completion (Anticipated): January 1, 2023
• Study Completion (Anticipated): January 1, 2023

Study Registration Dates

• First Submitted: December 17, 2020
• First Submitted That Met QC Criteria: December 28, 2020
• First Posted (Actual): December 30, 2020

Study Record Updates

• Last Update Posted (Actual): July 8, 2021
• Last Update Submitted That Met QC Criteria: July 7, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Keywords: heart failure; resistance training; rehabilitation therapy
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Failure
• Other Study ID Numbers: 2020044

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No