Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU

July 8, 2022 updated by: Lev VOLKOV, Central Hospital, Nancy, France

Clinical Outcomes and Characteristics of Critically Ill Patients With Influenza and COVID-19 Induced ARDS: a Retrospective, Matched Cohort Study

Since the beginning of the SARS CoV 2 pandemia, the SARS CoV 2 was frequently compared with the seasonal influenza virus. However, few studies compared patients presenting acute respiratory distress syndrome (ARDS) induced by these viruses, with results being discordant. Our study means to compare mortality and morbidity of patients hospitalized in an intensive care unit (ICU) with ARDS induced by SARS CoV-2 and seasonal influenza.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

157

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Nancy, France, 54000
        • CHRU Nancy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

patients hospitalized in Intensive Care Unit Hopital Central, Regional University Hospital of Nancy, France

- hospitalized between 2009 and 2019 if influenza and in 2020 if SARS CoV 2

Description

Inclusion Criteria:

  • patients hospitalized in ICU
  • under mechanical ventilation
  • presenting an ARDS according to the Berlin definition
  • induced by either influenza or SARS CoV 2

Exclusion Criteria:

  • pregnant women
  • mechanical ventilation>48 hours before admission

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
patients with ARDS induced by SARS CoV 2
Other: no intervention
no intervention, retrospective comparison
patients with ARDS induced by influenza
Other: no intervention
no intervention, retrospective comparison

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
mortality
Time Frame: at 28 days
at 28 days

Secondary Outcome Measures

Outcome Measure
Time Frame
length of stay in ICU
Time Frame: at 28 days
at 28 days
length of mechanical ventilation
Time Frame: at 28 days
at 28 days
length of vasopressors
Time Frame: at 28 days
at 28 days
length of extrarenal epuration
Time Frame: at 28 days
at 28 days
amount of drugs for sedation
Time Frame: at 28 days
at 28 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2021

Primary Completion (Actual)

July 10, 2021

Study Completion (Actual)

July 10, 2021

Study Registration Dates

First Submitted

June 24, 2021

First Submitted That Met QC Criteria

June 24, 2021

First Posted (Actual)

June 28, 2021

Study Record Updates

Last Update Posted (Actual)

July 12, 2022

Last Update Submitted That Met QC Criteria

July 8, 2022

Last Verified

July 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2021PI076

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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