Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome (PCOS-RCE)

June 6, 2022 updated by: Canadian Medical and Surgical Knowledge Translation Research Group

The Characterization of Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome

PCOS-RCE is an observational, cross-sectional, two-arm study that is aimed at determining if an established diagnosis of polycystic ovarian syndrome (PCOS) influences the number of blood vessel-forming stem cells in the bloodstream. Circulating progenitor cells will be enumerated and the distribution patterns of these cell types will be assessed to determine if these parameters differ between individuals with PCOS and individuals without PCOS. Specifically, this study will evaluate if differential regenerative cell exhaustion (RCE) may account, at least in part, for the differences in cardiovascular risk reported between individuals with a diagnosis of PCOS and those without.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

Individuals with polycystic ovarian syndrome (PCOS) have been reported to be at higher risk of cardiovascular disease when compared to those without PCOS. While differential environmental exposures and genetic morphometries are believed to account in part for the difference, there is growing evidence that cardiometabolic risk factors can accelerate pro-vascular progenitor cell depletion and dysfunction. The cumulative effects that aberrant regenerative cell exhaustion (RCE) have on vessel repair accordingly increases the risk of atherothrombotic events.

PCOS-RCE is an observational, cross-sectional, two-arm study that will evaluate the progenitor cell profiles of peripheral blood samples from 30 individuals (15 with PCOS, 15 without PCOS). The working hypothesis is that individuals with PCOS have innately different progenitor cell profiles that can be further altered by their environment and genotype. The resultant differences in RCE capability will affect the balance between pro-inflammatory and vessel repair functions that, in turn, contribute to the contrasting cardiometabolic risks exhibited between the two study cohorts.

Study Type

Observational

Enrollment (Anticipated)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Canada
    • Ontario
      • Newmarket, Ontario, Canada, L3Y 2N1
        • Centrum Services Newmarket
        • Contact:
          • Shakkeela Padanilathu Kunjummar, MD
          • Phone Number: 9058538525
        • Contact:
          • Christina Austin
          • Phone Number: 9058538525
      • Scarborough, Ontario, Canada, M1S 4N6
        • Diagnostic Assessment Centre
        • Contact:
          • Subodh Verma, MD PhD
      • Woodbridge, Ontario, Canada, L4L 1A6
        • Langstaff Medical Centre
        • Contact:
          • Kristin Terenzi, MD
          • Phone Number: 9058568086

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

Participants will be identified from primary care clinics in the Greater Toronto Area using paper-based and electronic medical records.

Description

Inclusion Criteria:

  • Capable and willing to provide informed consent
  • Females aged 30 and above

  • Must meet criteria for one of the following two groups:

    1. Documented diagnosis of PCOS OR
    2. Normal and regular menstrual cycles with no known diagnosis of PCOS

Exclusion Criteria:

  • Menopause, as defined by 12 months of amenorrhea
  • Known causes of irregular menstrual bleeding caused by conditions other than PCOS
  • Known secondary causes of ovulatory dysfunction and/or hyperandrogenism
  • Current pregnancy, active lactation, or less than 6 months postpartum
  • Ongoing treatment with ovulation-inducing medication
  • History of hysterectomy and/or bilateral oophorectomy
  • Severe congestive heart failure (as defined by New York Heart Association - class IV)
  • Any life-threatening disease expected to result in death within the next 2 years
  • Any malignancy not considered cured. A subject is considered cured if there has been no evidence of cancer recurrence for the 5 years prior to screening.
  • Known severe liver disease
  • Known acquired immunodeficiency syndrome such as HIV
  • Current treatment with systemic or oral corticosteroid therapy or other immunosuppressive agents
  • Known autoimmune disorder (exception: type 1 diabetes)
  • Active infectious disease requiring antibiotic or anti-viral agents

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Individuals with polycystic ovarian syndrome
Individuals with a documented diagnosis of polycystic ovarian syndrome
Individuals without polycystic ovarian syndrome
Individuals without a known diagnosis of polycystic ovarian syndrome but with regular menstrual cycles

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Frequency of circulating ALDHhiSSChi granulocytes
Time Frame: Baseline
Difference in the frequency of circulating ALDHhi SSChi granulocytes between women with PCOS versus without PCOS
Baseline

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of circulating ALDHhiSSCmid monocytes
Time Frame: Baseline
Difference in the number of circulating ALDHhi SSCmid monocytes with M1 vs M2 polarization between women with PCOS versus without PCOS
Baseline
Number of circulating ALDHhiSSClo primitive progenitor cells
Time Frame: Baseline
Difference in the number of circulating ALDHhi SSClo primitive progenitor cells in women with PCOS versus without PCOS
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Canadian Medical and Surgical Knowledge Translation Research Group

Investigators

  • Principal Investigator: David A Hess, PhD, University of Western Ontario, Canada

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

June 1, 2022

Primary Completion (Anticipated)

February 1, 2023

Study Completion (Anticipated)

April 1, 2023

Study Registration Dates

First Submitted

June 6, 2022

First Submitted That Met QC Criteria

June 6, 2022

First Posted (Actual)

June 8, 2022

Study Record Updates

Last Update Posted (Actual)

June 8, 2022

Last Update Submitted That Met QC Criteria

June 6, 2022

Last Verified

June 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Pro00063366

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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