Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome (PCOS-RCE)

Inclusion Criteria:

• Capable and willing to provide informed consent
• Females aged 30 and above

• Must meet criteria for one of the following two groups:

  1. Documented diagnosis of PCOS OR
  2. Normal and regular menstrual cycles with no known diagnosis of PCOS

Exclusion Criteria:

• Menopause, as defined by 12 months of amenorrhea
• Known causes of irregular menstrual bleeding caused by conditions other than PCOS
• Known secondary causes of ovulatory dysfunction and/or hyperandrogenism
• Current pregnancy, active lactation, or less than 6 months postpartum
• Ongoing treatment with ovulation-inducing medication
• History of hysterectomy and/or bilateral oophorectomy
• Severe congestive heart failure (as defined by New York Heart Association - class IV)
• Any life-threatening disease expected to result in death within the next 2 years
• Any malignancy not considered cured. A subject is considered cured if there has been no evidence of cancer recurrence for the 5 years prior to screening.
• Known severe liver disease
• Known acquired immunodeficiency syndrome such as HIV
• Current treatment with systemic or oral corticosteroid therapy or other immunosuppressive agents
• Known autoimmune disorder (exception: type 1 diabetes)
• Active infectious disease requiring antibiotic or anti-viral agents