Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

November 28, 2022 updated by: Bengü Gülhan Köksal, Zonguldak Bulent Ecevit University

The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Kozlu
      • Zonguldak, Kozlu, Turkey, 67600
        • Zonguldak Bülent Ecevit University Medicine Faculty

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 66 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients aged 18-65 years who have underwent forearm surgery

Description

Inclusion Criteria:

  • Underwent forearm surgery
  • Between aged 18-70
  • Under general anesthesia or peripheral nerve block

Exclusion Criteria:

  • acute infection
  • morbid obesity
  • chronic treatment with steroids or immunosuppressants
  • recently received chemotherapy
  • hepatic and renal dysfunction;
  • chronic alcohol abusers
  • Multiple trauma
  • Patients with missing data in their files

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Group G
Patients Undergoing Forearm Surgery under general anesthesia
Group P
Patients Undergoing Forearm Surgery under peripheral nerve block
Procedure: peripheral nerve block
local anesthetic application to the brachial plexus

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Neutrophil/lymphocyte ratio
Time Frame: up to 24 hours after surgery
Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
up to 24 hours after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Platelet/lymphocyte ratio
Time Frame: up to 24 hours after surgery
Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
up to 24 hours after surgery
Mean Platelet Volume
Time Frame: up to 24 hours after surgery
Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block
up to 24 hours after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zonguldak Bulent Ecevit University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2018

Primary Completion (Actual)

November 1, 2020

Study Completion (Actual)

November 1, 2021

Study Registration Dates

First Submitted

November 17, 2022

First Submitted That Met QC Criteria

November 28, 2022

First Posted (Actual)

November 29, 2022

Study Record Updates

Last Update Posted (Actual)

November 29, 2022

Last Update Submitted That Met QC Criteria

November 28, 2022

Last Verified

November 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2020-22/17

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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