A Study of OMX-0407 in Patients With Previously Treated Solid Tumours That Can't be Removed Surgically

A Phase I/Ib Dose Escalation and Cohort Expansion Study of OMX-0407 a Salt-inducible Kinase Inhibitor in Patients With Previously Treated Unresectable Solid Tumours

The main purpose of the dose escalation phase of the study is to determine the safety of different doses of OMX-0407.

The dose expansion (phase Ib) part of the study will evaluate efficacy, safety and tolerability at a dose determined in the dose escalation,

Study Overview

• Status: Terminated
• Conditions: Solid Tumor
• Intervention / Treatment: Drug: OMX-0407

• Study Type: Interventional
• Enrollment (Actual): 68
• Phase: Phase 2; Phase 1

Contacts and Locations

Study Locations

• Belgium
  • Brussels, Belgium, 1200
    • Cliniques Universitaires Saint-Luc
  • Ghent, Belgium, 9000
    • Universitair Ziekenhuis Gent
  • Liège, Belgium, 4000
    • CHU de Liège
  • Wilrijk, Belgium, 2610
    • ZAS Augustinus Afdeling Oncologische Research
• France
  • Bordeaux, France
    • UNICANCER-Institut Bergonie - Nouvelle-Aquitaine
  • Lyon, France
    • Universite de Lyon - Centre Leon-Berard (CLB)
  • Marseille, France
    • Assistance Publique Hopitaux de Marseille- Hopital de La Timone
  • Montpellier, France
    • Institut du Cancer Montpellier (ICM)
  • Nantes, France
    • Institut de Cancerologie de Ouest (ICO) - Saint-Herblain
  • Nantes, France
    • UNICANCER - Centre Oscar Lambret
  • Paris, France
    • Gustave Roussy - Institut Gustave Roussy
  • Toulouse, France
    • CHU de Toulouse
• Spain
  • Barcelona, Spain, 08003
    • Hospital del Mar
  • Barcelona, Spain, 08035
    • Hospital Universitario Vall d'Hebron
  • Barcelona, Spain
    • NEXT Oncology - Hospital Quironsalud Barcelona
  • Madrid, Spain, 28007
    • Hospital Universitario Gregorio Maranon
  • Madrid, Spain, 28027
    • Clinica Universidad de Navarra
  • Madrid, Spain, 28050
    • Centro Integral Oncologico Clara Campal
  • Madrid, Spain, 28033
    • MD Anderson Cancer Center
  • Madrid, Spain, 28040
    • START Madrid - Hospital Fundacion Jimenez Diaz
  • Madrid, Spain
    • NEXT Oncology - Hospital Universitario Quironsalud
  • Pamplona, Spain, 31008
    • Clinica Universidad de Navarra
  • Valencia, Spain, 46026
    • Hospital La Fe de Valencia
  • Barcelona
    • L'Hospitalet de Llobregat, Barcelona, Spain, 08906
      • ICO Hospitalet

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

General Inclusion Criteria for Cohort Expansion Phases

1. Age ≥18 years (≥16 years for the AS expansion cohort) and willing to provide informed consent for the study.
2. Cytological or pathological confirmation of advanced cancer.
3. Subjects treated in three subject cohorts onwards will be required to provide either archival tumour material or be willing to undergo a core biopsy to provide tumour material during screening.
4. Subjects should have completed or be unsuitable for licensed therapies for their primary cancer unless such therapies are not available according to local practice - for example not reimbursed or included in treatment guidelines. All subjects must have received at least one previous line of systemic therapy for the tumour type under investigation. Subjects who have declined treatment or according to their treating physician are unsuitable for an existing licensed therapy are eligible for the study.
5. Eastern Cooperative Oncology Group (ECOG) Performance status 0, 1 or 2. Subjects treated in the cohort expansion phase of the study should have an ECOG Performance status of 0 or 1.
6. Able to swallow oral medication with no existing evidence of underlying gastrointestinal malabsorption or abnormal gastrointestinal transit.
7. For female subjects and male partners of childbearing potential, willingness and able to use two forms of highly effective contraception methods (e.g., oral contraceptive and condom, intra-uterine device, and condom) while on study and for 30 days after the last study treatment. For male subjects and female partners of childbearing potential, willingness and able to use two forms of highly effective contraception methods (e.g., oral contraceptive and condom, intra-uterine device, and condom) while on study and for 3 months after the last study treatment. Women who last experienced menses more than one year previously or who have undergone bilateral ovariectomy, hysterectomy or tubal ligation which is documented in their medical notes do not require to use contraception during or after treatment with OMX-0407. Male subjects who have previously undergone vasectomy are not required to use contraception.
8. All toxicity from previous anti-cancer therapy including radiotherapy must have recovered to either Grade I or stable Grade II (CTCAE v5).
9. Subjects should have at least evaluable tumour by Response Evaluation Criteria in Solid Tumours (RECIST) 1.1 criteria. Subjects treated in the Cohort Expansion phases of the study should have measurable disease.

Additional Inclusion Criteria For Cohort Expansion Phase: ccRCC

1. Prior histological confirmation of clear cell renal cell carcinoma. In the case of mixed histology in order to be eligible at least 70% of reviewed tumour should be of clear cell histology.
2. Subjects with known renal vascular involvement should be on stable anticoagulation at the start of treatment with OMX-0407. Tumour/skin biopsies should be performed prior to the onset of anticoagulation.
3. Previous treatment must include PD-1 blockade and VEGFR inhibition.

Additional Inclusion Criteria for Cohort Expansion Phase: AS

1. Clinical and histopathological confirmation of advanced/metastatic or unresectable visceral AS, cutaneous AS secondary to radiotherapy or other cutaneous AS.
2. Subjects should have progressive disease
3. Subject has received at least one prior line of systemic therapy for metastatic or unresectable disease which must have included a taxane or an anthracycline.
4. Willingness to undergo serial tumour biopsies before and during study treatment.

Patient will still be eligible if the investigator deems the biopsy procedure to be an unacceptable health risk to the patient.

General Exclusion Criteria for Cohort Expansion Phases

1. Untreated CNS metastases. Subjects with CNS metastases that have completed treatment at least two weeks previously and have either an unchanging or no neurological deficit whilst not receiving corticosteroid therapy are eligible. Subjects with known CNS metastases must have received CNS directed therapy and not systemic therapy alone to be eligible for the study.
2. Either Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) > 2.5 upper limit of normal (ULN) unless in the presence of hepatic metastases when AST or ALT as high as 5 ULN is acceptable. Serum bilirubin > 1.5 ULN unless in the presence of hepatic metastases when serum bilirubin as high as 3 x ULN is acceptable. Subjects with isolated increases in alkaline phosphatase (ALK) are eligible for the study.
3. Prothrombin Time or equivalent such as international normalized ratio (INR) or the Quick test > 1.5 ULN.
4. Activated Partial Thromboplastin Time (PTT) > 1.5 ULN.
5. Chronic anticoagulant therapy that cannot be discontinued for tumour biopsy if necessary.
6. Previous biological or unlicensed anticancer therapy within five half-lives or thirty days of treatment - whichever is shortest.
7. Prior cytotoxic chemotherapy in the preceding three weeks.
8. Persistent fever or other signs of uncontrolled infection.
9. Creatinine clearance by Cockcroft-Gault formula or local equivalent < 30 ml/min.
10. Allergy to OMX-0407 or any of its excipients.
11. Personal or family history of long QT syndrome or sudden death.
12. Family or personal history of ventricular arrythmia. Known untreated aberrant preexcitation pathways such as Wolf-Parkinson-White syndrome. Ongoing atrial fibrillation unless the ventricular rate is controlled by medical therapy.
13. Unstable hypertension requiring changes in antihypertensive medication within the preceding three months, Myocardial Infarction or Cerebrovascular accident within the preceding three months. Cardiac failure New York Heart Association (NYHA) Grade III or IV.
14. Abnormal echocardiogram (ECHO) according to investigational site criteria including a normal Ejection Fraction.
15. QTc interval after Fridericia correction of greater than 450 ms (man) or 460 ms (woman) (mean of three readings performed at least five minutes apart).
16. Second degree Atrioventricular block or cardiac pacemaker.
17. Subject must have fully recovered from major surgery such as thoracotomy. Open biopsy or insertion of a venous access device does not constitute major surgery.
18. Known active Hepatitis B (HBV) or C (HCV) including subjects receiving antiviral therapy. Subjects with a history of hepatitis are eligible for the study if they are positive for anti-HBs or do not have detectable HCV mRNA at least six weeks from completing antiviral therapy.
19. Ongoing disabling systemic disease such chronic obstructive pulmonary disease (COPD) or depression or other psychiatric illnesses which may reduce study compliance.
20. Ongoing drug dependence or parenteral substance abuse.
21. Concurrent use of medications at risk of Torsade de pointes under normal clinical usage.
22. Live vaccinations in the preceding four weeks.
23. Subjects who have received treatment for another malignancy in the preceding three years other than squamous cell or basal cell carcinoma of the skin, Carcinoma In Situ of the uterine cervix, Ductal Carcinoma In Situ of the breast, non-muscle invasive carcinoma of the bladder, melanoma in situ or adenocarcinoma of the prostate (Gleason score of five or less).

24. Myelosuppression defined as any of the below:

    Haemoglobin <9.5 g/dl White Cell Count <2 x 1000 per μl Neutrophils <1.5 x 1000 per μl Platelets <75 000 per μl Independent of haematopoietic growth factors and transfusion

25. Receipt of any other investigational anticancer agent within 28 days prior to first administration of OMX-0407.
26. Female subjects must not be pregnant or breast feeding.

Additional Exclusion Criteria for Cohort Expansion Phase: ccRCC 1. Uncontrolled hypertension defined as persistent BP greater than Diastolic 90 mm Hg and Systolic 150 mm Hg

Additional Exclusion Criteria for Cohort Expansion Phase: ccRCC and AS

1. More than 3 previous lines of therapy in an unresectable or metastatic setting.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: OMX-0407 - Escalation Phase; A starting daily dose of 20 mg OMX-0407 per participant split into twice daily 10 mg. Dose escalation will be determined by the safety monitoring committee. Dose for expansion will be determined by the safety monitoring committee.	Drug: OMX-0407; Dose escalation, Dose expansion
Experimental: OMX-0407 - Expansion Phase (Phase Ib); A dose of 100 mg OMX-0407 will be orally administered twice daily.	Drug: OMX-0407; Dose escalation, Dose expansion

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Identify Dose Limiting Toxicities	Incidence of dose limiting toxicities at each dose level	4 weeks (1 cycle)
Identify objective response rate	Number of objective responses of OMX-0407 in patients with Renal Cell cancer, Non small cell lung cancer, urothelial cancer and angiosarcoma	Every 12 weeks (3 cycles)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Maximum Tolerated Dose	Identify the maximum tolerated dose and recommended dose for Phase II based on toxicities at each dose level	evaluated up to approximately 3 years
Investigate the safety and tolerability of OMX-0407	Incidence and severity of adverse events at each dose level	through study completion, estimated up to approximately 3 years
Pharmacokinetics (Cmax) of OMX-0407	Maximum observed plasma concentration	evaluated up to approximately 3 years
Pharmacokinetics (Tmax) of OMX-0407	Time of maximum observed plasma concentration	evaluated up to approximately 3 years
Pharmacokinetics (AUClast) of OMX-0407	Area under the plasma concentration-time curve from time of dosing to the last quantifiable timepoint	evaluated up to approximately 3 years
Pharmacokinetics (AUCinf) of OMX-0407	Area under the plasma concentration-time curve from time of dosing to infinity	evaluated up to approximately 3 years
Pharmacokinetics (% extrapolated-AUCinf) of OMX-0407	The percentage of AUCinf derived via extrapolation from Tlast	evaluated up to approximately 3 years
Pharmacokinetics (t½) of OMX-0407	Terminal elimination half-life	evaluated up to approximately 3 years
Measure Duration of Response	Determine the median duration of response according to RECIST 1.1	every 12 weeks (3 cycles)
Measure Progression Free Survivial	Determine the median time for progression free survival	every 12 weeks (3 cycles)
Measure Overall Response Rates	Determine the overall number of responses	every 12 weeks (3 cycles)
Measure Overall Survival	Determine the survival times of patients	every 12 weeks (3 cycles)
Assess Quality of Life	Determine changes in quality of life	Every 4 weeks (1 cycle)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Explore Target Kinase Inhibition	Changes in selected kinase activity and T cell subset analysis in circulating peripheral blood cells, skin and tumour biopsy material	evaluated up to approximately 3 years
Explore and characterize the metabolites of OMX-0407	Analysis of metabolites presence in serum blood samples	evaluated up to approximately 3 years
Explore associations of pre-treatment tumour biology with treatment outcome	Analyse the molecular features pre and post treatment	evaluated up to approximately 3 years

Collaborators and Investigators

• Sponsor: iOmx Therapeutics AG

Study record dates

Study Major Dates

• Study Start (Actual): March 30, 2023
• Primary Completion (Actual): April 2, 2026
• Study Completion (Actual): April 2, 2026

Study Registration Dates

• First Submitted: March 14, 2023
• First Submitted That Met QC Criteria: April 12, 2023
• First Posted (Actual): April 24, 2023

Study Record Updates

• Last Update Posted (Actual): April 24, 2026
• Last Update Submitted That Met QC Criteria: April 21, 2026
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Keywords: Renal Cell Carcinoma; Angiosarcoma
• Additional Relevant MeSH Terms: Urogenital Diseases; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Male Urogenital Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Adenocarcinoma; Urologic Neoplasms; Carcinoma; Kidney Neoplasms; Sarcoma; Neoplasms, Connective and Soft Tissue; Neoplasms, Vascular Tissue; Carcinoma, Renal Cell; Hemangiosarcoma
• Other Study ID Numbers: OMX-0407-101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; ICF; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No