Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions (SVF)

August 20, 2025 updated by: Amer Mansour, Dubai Health Authority
clinical efficacy of autologous stromal vascular fraction SVF,for inflammatory and degenerative conditions of the knees

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

to evaluate the clinical effectiveness of point of care autologous adipose derived stromal vascular fraction (SVF) alone or in combination with exosomes,for inflammatory and degenerative conditions of the knees.

Study Type

Interventional

Enrollment (Estimated)

300

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • knee osteoarthritis any grade

    • knee chondromalacia grade 2 and above

Exclusion Criteria:

  • active HIV
  • pregnant women
  • Mental disease
  • severe cardio vascular disease
  • severe coagulation disorders
  • infected tissues
  • patients on other experimental studies within 3 months

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: knee osteoarhritis
patients with grade 2 and above chondromlacia as well as all grades of osteoarhtritis
Procedure: stromal vascular fraction injection in the osteoarthritic knee
stromal vascular fraction harvested from mid abdominal wall under sedation and seperated from fat using mechanical centrifugation .injection of 5 cc of the SVF in the affected knee.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
change in pain level
Time Frame: 2 years
visual analog scale 0-10 ( 10 being worst)
2 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
percentage cartilage thickness change
Time Frame: 2 years
as measured by MRI
2 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Dubai Health Authority

Investigators

  • Study Director: DHA DHA, dubai health autority

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 30, 2026

Primary Completion (Estimated)

December 30, 2027

Study Completion (Estimated)

December 1, 2028

Study Registration Dates

First Submitted

August 2, 2023

First Submitted That Met QC Criteria

August 17, 2023

First Posted (Actual)

August 21, 2023

Study Record Updates

Last Update Posted (Estimated)

August 26, 2025

Last Update Submitted That Met QC Criteria

August 20, 2025

Last Verified

August 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DHA

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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