Developement of Stroke Prognosis Predictive Precision Medicine Based on a Digital Twin

March 16, 2026 updated by: Seyoung Shin

Developement of Prognosis Predictive Precision Medicine Based on a Digital Twin Reflecting the Motor Patterns in Stroke Patients

The purpose of this study is to realize customized precision medicine for stroke patients and the visual digitization of patient medical information required in the era of digital transformation.

This study will collect large-scale, high-quality clinical data and daily life exercise pattern data covering the subacute to chronic stages of stroke patients. Based on this, we will use artificial intelligence analysis technology to predict the functional status of stroke patients in the chronic stage after their disability is fixed. We aim to develop the next generation of personalized digital twins by creating a prognostic prediction model.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

1192

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • South Korea
    • Gyeonggi-do
      • Gyeonggi-do, Gyeonggi-do, South Korea, 13497
        • Bundang CHA Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Stroke patients receiving treatment at four hospitals in Korea

Description

Inclusion Criteria:

  • Adults over 20 years of age with a history of stroke onset between 2018.01.01 to 2023.07.31.
  • Patients who exist rehabilitation medical evaluation after stroke onset
  • Patients who voluntarily decide to participate in this study

Exclusion Criteria:

  • Those who have severe internal diseases such as unstable conditions of the cardiovascular system, digestive system, respiratory system, endocrine system, etc. and are in poor overall condition.
  • Those who have impaired ability to consent (MMSE score less than 10 points) and not accompanied by a care-giver.
  • In any other cases where the researcher determines that participation in this study is not appropriate.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Stroke patients
Patients diagnosed with stroke at four hospitals in Korea
Other: Stroke
No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Modified Barthel Index (MBI)
Time Frame: minimum 6 months to maximum 6 years
A scale to measure disability or dependence in activities of daily living (ADL) of stroke survivors (range 0-100)
minimum 6 months to maximum 6 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mini Mental Status Examination (MMSE)
Time Frame: minimum 6 months to maximum 6 years
Mini-Mental State Examination (MMSE) is a 30-question assessment of cognitive function that evaluates attention and orientation, memory, registration, recall, calculation, language and ability to draw a complex polygon (range 0-30)
minimum 6 months to maximum 6 years
Functional Ambulatory Category (FAC)
Time Frame: minimum 6 months to maximum 6 years
The Functional Ambulation Categories (FAC) is a 6-point functional walking test that evaluates ambulation ability, determining how much human support the patient requires when walking, regardless of whether or not they use a personal assistive device. (range 0-5)
minimum 6 months to maximum 6 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seyoung Shin

Investigators

  • Principal Investigator: Seyoung Shin, MD, CHA University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 5, 2023

Primary Completion (Actual)

December 31, 2025

Study Completion (Actual)

December 31, 2025

Study Registration Dates

First Submitted

August 30, 2023

First Submitted That Met QC Criteria

September 6, 2023

First Posted (Actual)

September 13, 2023

Study Record Updates

Last Update Posted (Actual)

March 18, 2026

Last Update Submitted That Met QC Criteria

March 16, 2026

Last Verified

February 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RS-2023-00262005

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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