The Relationship Between Personality Traits and Perioperative Anesthetic Drug Consumption

In this study, we aimed to examine the association between personality traits and amount of anesthetic drug consumption,of the patients who will receive sedoanalgesia for the oocyte retrieval procedure. As well as determining the anxiety scores in the preoperative period, the time to reach the desired sedation level, hemodynamic parameters in the perioperative period, peripheral oxygen saturation, EtCO2 value, postoperative pain, postanesthetic recovery, analgesic drug need, unconscious movement, and patient satisfaction.

Study Overview

• Status: Completed
• Conditions: Infertility; Anesthesia
• Intervention / Treatment: Other: PBQ-S1

Detailed Description

Different personality traits, anxiety disorders, depression, and somatoform disorders are frequently encountered in women with infertility problems. Although there are many studies evaluating the relationship of anxiety with variables such as hemodynamic parameters, need for anesthetic medication, recovery times, postoperative pain and analgesic requirements, the relationship between personality traits and these variables has not been investigated.

In our study, considering that the anesthesia needs of these patients with a stressful negative factor such as infertility may be at different levels, preoperative evaluation of the patients with a personality questionnaire will provide better perioperative management, a better quality recovery and possibly a higher quality oocyte aspiration. In this study, it was aimed to investigate the amount of anesthetic agent consumption, recovery times, postoperative pain scores, analgesic requirements, involuntary movement, time to reach sufficient sedation depth, and patient satisfaction of patients thought to have sedation.

All patients will fill out Personality Belief Scale-Short Form (PBQ-S1) and Beck Anxiety Scale one day before the procedure and they will be registered.

• Study Type: Observational
• Enrollment (Actual): 90

Contacts and Locations

Study Locations

• Turkey
  • Atakum
    • Samsun, Atakum, Turkey, 55000
      • Ondokuz Mayis University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Female patients between 18-50 ages who will undergo oocyte pick up procedure with sedation

Description

Inclusion Criteria:

• 18- 50 year-old elective patients who signed the informed consent form from ASA I-II patients scheduled for oocyte retrieval.
• Patients with sufficient education and mental capacity to complete in assessment scales and questionnaires.
• Patients without neurological disorders, psychological illnesses, or drug or alcohol abuse
• Patients without stimulant drug and alcohol consumption
• Absence of significant cardiovascular, respiratory, kidney or liver disease.

Exclusion Criteria:

• Psychiatric or neurological disorder
• Psychiatric drug use or alcohol consumption
• Pregnancy
• Presence of severe cardiac, hepatic or cerebrovascular disease
• History of allergy to local anesthetics or systemic opioids
• History of chronic pain
• Patients who are unable to evaluate scales and questionnaires

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group PT-PADC; patients who will receive sedoanalgesia for the oocyte retrieval procedure.	Other: PBQ-S1; All patients will fill out Personality Belief Scale-Short Form (PBQ-S1) and Beck Anxiety Scale one day before the procedure and they will be registered.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Propofol consumption	mg, from the beginning to the end of the transvaginal oocyte retrieval procedure	from the beginning to the end of the transvaginal oocyte retrieval procedure)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time until the Ramsey Sedation Score of 4 is reached	The period elapsed after the patient is transported to the operating table and the sedation protocol begins.	-The period of time starting with the propofol injection until the Ramsey Sedation Score of 4
Amount of propofol (mg) used until the required sedation depth is reached	The amount of iv propofol administered until the Ramsey Sedation Score of 4 is obtained	The period of time starting with the propofol injection until the Ramsey Sedation Score of 4
Systolic, diastolic and, mean Blood pressure (mm/Hg)	It will be monitored and documented every 5 minutes during the procedure.	every 5 minutes during the procedure
Heart rate (beats/min)	It will be monitored and documented every 5 minutes during the procedure.	every 5 minutes during the procedure.
Peripheral oxygen saturation (%)	(%): It will be monitored and documented every 5 minutes during the procedure.	every 5 minutes during the procedure
Number of Involuntary movement during the procedure	The presence of involuntary movement will be documented during the procedure.	during the procedure.
Postoperative pain (visual analog scale)	Pain status will be evaluated based on visual analog scale (VAS) at rest and after movement.every 30-minute intervals for one hour in the recovery room. Each VAS is scores 0-10 (0=no pain, 10=unbearable pain)	After the procedure,every 30 minutes up to 1 hour
Analgesic consumption	The analgesic agents administered to the patients throughout the postoperative period will be documented.	postoperatively up to 2 hours
Postoperative recovery time	The time until the Modified Aldrete Score reaches 9 points will be determined.	postoperatively up to 2 hours
The incidences of post-operative nausea and vomiting (PONV)	the presence of nausea and vomiting will be recorded for 24 hours after procedure	the time from the end of the procedure until discharge
Undesirable events and interventions	Bradycardia, hypotension, airway obstruction, hypoxia will be documented throughout the perioperative phase with the intervention.	time between start of procedure and discharge

Collaborators and Investigators

• Sponsor: Ondokuz Mayıs University

Publications and helpful links

General Publications

• Maranets I, Kain ZN. Preoperative anxiety and intraoperative anesthetic requirements. Anesth Analg. 1999 Dec;89(6):1346-51. doi: 10.1097/00000539-199912000-00003.
• Lee SS, Kim HH, Park HJ. Are Histrionic Personality Traits Associated with Irritability during Conscious Sedation Endoscopy? Gastroenterol Res Pract. 2015;2015:702492. doi: 10.1155/2015/702492. Epub 2015 Apr 12.
• CLARIDGE GS, HERRINGTON RN. Sedation threshold, personality, and the theory of neurosis. J Ment Sci. 1960 Oct;106:1568-83. doi: 10.1192/bjp.106.445.1568. No abstract available.

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2023
• Primary Completion (Actual): March 30, 2024
• Study Completion (Actual): July 30, 2024

Study Registration Dates

• First Submitted: July 10, 2023
• First Submitted That Met QC Criteria: October 17, 2023
• First Posted (Actual): October 23, 2023

Study Record Updates

• Last Update Posted (Actual): April 1, 2025
• Last Update Submitted That Met QC Criteria: March 26, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: Anxiety; Acute pain; Personality traits; Anesthetic Drug Consumption
• Additional Relevant MeSH Terms: Urogenital Diseases; Genital Diseases; Infertility
• Other Study ID Numbers: PT-PADC

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No