Early Diagnosis of Acute Renal Failure by Urine Trehalase Levels.

July 11, 2024 updated by: İlke Dolgun, Istinye University

Early Diagnosis of Acute Renal Failure, Which May Occur in Patients After Surgeries Requiring Hypotensive Anesthesia, by Urine Trehalase Levels.

We think that in surgical patients requiring hypotensive anesthesia, acute kidney injury, which may occur due to intraoperative renal hypoperfusion, can be diagnosed early by evaluating the urine trehalase value using the ELISA method, and thus, early diagnosed acute renal failure can be treated quickly and patients can be protected from subsequent complications in the postoperative period.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey
    • Merkez Mahallesi
      • Istanbul, Merkez Mahallesi, Turkey, 34250
        • istinye University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

40 patients between the ages of 18-65 who underwent a surgical operation requiring hypotensive anesthesia will be included in the study.

Description

Inclusion Criteria:

  • Being over the age of 18 and under the age of 65
  • Having signed the BGOF form to be included in the study,
  • Being in ASA 1 or ASA 2 classification
  • Not having kidney failure or kidney disease
  • No history of single kidney or renal transplantation
  • Not using nephrotoxic drugs or agents before surgery
  • Renal function tests taken preoperatively should be within normal ranges.
  • No urinary tract infection or urinary problems (such as polyuria, oliguria or anuria)

Exclusion Criteria:

  • Those under the age of 18 or over the age of 65
  • Those who do not want to participate in the study
  • ASA 3 and above
  • Having previously received treatment for kidney disease - including kidney stones -
  • Having been previously diagnosed with acute or chronic renal failure
  • Having a single kidney or a history of renal transplantation
  • Using nephrotoxic drugs or agents (such as contrast material) before surgery
  • Kidney function tests taken preoperatively are not within normal ranges
  • Having a urinary tract infection or urinary problem (such as polyuria, oliguria or anuria)
  • Having a history of kidney stones, acute renal failure or chronic renal failure
  • Those with active infection or disease before surgery
  • They were determined as patients for whom consent was not obtained for the study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
trehalase levels
Time Frame: 1 month
urine trehalase levels
1 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Istinye University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 15, 2024

Primary Completion (Estimated)

August 15, 2024

Study Completion (Estimated)

September 15, 2024

Study Registration Dates

First Submitted

July 11, 2024

First Submitted That Met QC Criteria

July 11, 2024

First Posted (Actual)

July 17, 2024

Study Record Updates

Last Update Posted (Actual)

July 17, 2024

Last Update Submitted That Met QC Criteria

July 11, 2024

Last Verified

July 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • istinye university trehalase

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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