Taurine in Periodontitis and Aging

The Role of Taurine in Periodontitis and Aging: a Preliminary Study

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

Study Overview

• Status: Completed
• Conditions: Aging; Peridontal Disease
• Intervention / Treatment: Diagnostic test: Periodontal Indices

• Study Type: Interventional
• Enrollment (Actual): 66
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Unkapani
    • Istanbul, Unkapani, Turkey
      • Istanbul Medipol University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Exclusion Criteria:

• ages 18-25 or 45-64
• use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
• presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
• pregnancy or lactation
• alcoholism
• smoking
• nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
• having less than 20 natural teeth, excluding third molars
• use of orthodontic appliances

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Young (25-44 years) with a healthy periodontium	Diagnostic test: Periodontal Indices; Saliva, serum and periodontal indexes were obtained from patients; Other Names: Salivary Flow Rate; TNF-α Levels; SIRT1 Levels; Taurine Levels
Experimental: young (25-44 years) with Periodontitis	Diagnostic test: Periodontal Indices; Saliva, serum and periodontal indexes were obtained from patients; Other Names: Salivary Flow Rate; TNF-α Levels; SIRT1 Levels; Taurine Levels
Experimental: Old (≥65 years) with a healthy periodontium	Diagnostic test: Periodontal Indices; Saliva, serum and periodontal indexes were obtained from patients; Other Names: Salivary Flow Rate; TNF-α Levels; SIRT1 Levels; Taurine Levels
Experimental: Old (≥65 years) with Periodontitis	Diagnostic test: Periodontal Indices; Saliva, serum and periodontal indexes were obtained from patients; Other Names: Salivary Flow Rate; TNF-α Levels; SIRT1 Levels; Taurine Levels

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Taurine	Taurine levels in saliva and serum were measured	12 Weeks
SIRT1	SIRT1 levels in saliva and serum were measured	12 Weeks
TNF-α	TNF-α levels in saliva and serum were measured	12 Weeks

Collaborators and Investigators

• Sponsor: Istanbul Medipol University Hospital

Study record dates

Study Major Dates

• Study Start (Actual): December 21, 2023
• Primary Completion (Actual): May 1, 2024
• Study Completion (Actual): June 1, 2024

Study Registration Dates

• First Submitted: October 4, 2024
• First Submitted That Met QC Criteria: October 9, 2024
• First Posted (Actual): October 10, 2024

Study Record Updates

• Last Update Posted (Actual): October 10, 2024
• Last Update Submitted That Met QC Criteria: October 9, 2024
• Last Verified: October 1, 2024

More Information

Terms related to this study

• Keywords: Biomarker; Inflammation; Aging; Periodontitis; TNF-α; Taurine; SIRT1
• Additional Relevant MeSH Terms: Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis
• Other Study ID Numbers: 1078

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Due to patients data privacy

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No