A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

April 17, 2026 updated by: Eli Lilly and Company

An Adaptive, Dose-Ranging, Phase 2 Study of Eltrekibart Given Alone or in Combination With Mirikizumab for the Treatment of Adult Patients With Moderately to Severely Active Ulcerative Colitis

The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

The study will last approximately 4-5 years. Screening is required within 35 days prior to enrollment. For each participant, the total duration of the clinical trial will be about 69 weeks including screening.

Study Type

Interventional

Enrollment (Estimated)

140

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Contact Backup

Study Locations

  • Argentina
      • CABA, Argentina, C1061AAS
        • Recruiting
        • CIPREC
        • Principal Investigator:
          • Claudia Fuxman
        • Contact:
          • Phone Number: +54 11 4875 67670
      • Ciudad Autonoma de Buenos Air, Argentina, C1128AAF
        • Recruiting
        • Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
        • Principal Investigator:
          • Emiliano Tron
        • Contact:
          • Phone Number: +54 114-514-3408
      • Munro, Argentina, 1605
        • Not yet recruiting
        • Clinica Privada Independencia
        • Principal Investigator:
          • Gaston Julian Gonzalez Segura
        • Contact:
          • Phone Number: 541147212354
      • Quilmes, Argentina, B1878DVB
        • Not yet recruiting
        • CER Instituto Medico
        • Principal Investigator:
          • Edgardo Gimenez
        • Contact:
          • Phone Number: +5411 5263-3113
      • Rosario, Argentina, S2002KDS
        • Recruiting
        • Hospital Provincial del Centenario
        • Principal Investigator:
          • Orlando Enrique Ruffinengo
        • Contact:
          • Phone Number: +54341 4393511
      • SAN M. de Tucuman, Argentina, T4000AXL
        • Recruiting
        • Centro Medico Privado de Reumatologia
        • Contact:
          • Phone Number: +543814200180
        • Principal Investigator:
          • María Perez
  • Belgium
      • La Louvière, Belgium, 7100
        • Recruiting
        • CHU Tivoli
        • Principal Investigator:
          • Gaël Englebert
        • Contact:
          • Phone Number: +3264276423
      • Yvoir, Belgium, 5530
        • Recruiting
        • CHU UCL Namur Site Godinne
        • Principal Investigator:
          • Jean-Francois Rahier
        • Contact:
          • Phone Number: +32 81 42 30 26
  • Canada
      • London, Canada, N6A 5W9
        • Recruiting
        • London Health Sciences Centre
        • Principal Investigator:
          • Terry Ponich
        • Contact:
          • Phone Number: 519-685-8500 ext: 77809
      • London, Canada, N6K 1M6
        • Not yet recruiting
        • London Digestive Disease Institute
        • Principal Investigator:
          • Vipul Jairath
        • Contact:
          • Phone Number: 519-204-6333
      • Montreal, Canada, H1T 2M4
        • Not yet recruiting
        • CIUSSS de l'Est-de-l'Île-de-Montréal
        • Contact:
          • Phone Number: 14-252-3400 ext 3242
        • Principal Investigator:
          • Marica Reise-Filtreau
      • Montreal, Canada, H3G 1A4
        • Not yet recruiting
        • Montreal General Hospital
        • Principal Investigator:
          • Waqqas Afif
        • Contact:
          • Phone Number: 514-934-1934 ext 36536
  • Colombia
      • Bogotá, Colombia, 111411
        • Not yet recruiting
        • Hospital Universitario Mayor Méderi
        • Contact:
          • Phone Number: +57 3045935015
        • Principal Investigator:
          • Carlos Edgar Figueroa Avendaño
      • Cali, Colombia, 750035
        • Not yet recruiting
        • Comité de Ética en Investigación Biomédica IPS Centro Médico Julián Coronel
        • Principal Investigator:
          • Henry Idrobo Quintero
      • Medellín, Colombia, 5001000
        • Not yet recruiting
        • Centro de Inmunología y Genética (CIGE)
        • Principal Investigator:
          • Luis Gonzalo Zapata
  • Croatia
      • Bjelovar, Croatia, 43000
        • Recruiting
        • General Hospital Dr Andjelko Visic Bjelovar
        • Contact:
          • Phone Number: +385 98 941 7873
        • Principal Investigator:
          • Marinko Lukic
      • Osijek, Croatia, 31000
        • Recruiting
        • Poliklinika Borzan
        • Principal Investigator:
          • Vladimir Borzan
        • Contact:
          • Phone Number: +385 91 521 1171
      • Rijeka, Croatia, 51000
        • Recruiting
        • Special Hospital Medico
        • Contact:
          • Phone Number: +385 91 154 6666
        • Principal Investigator:
          • Boris Brozovic
      • Slavonski Brod, Croatia, 35 000
        • Not yet recruiting
        • General Hospital Dr. J. Bencevic
        • Contact:
          • Phone Number: +38535201686
        • Principal Investigator:
          • Blazenka Miskic
      • Zagreb, Croatia, 10000
        • Recruiting
        • Poliklinika Solmed
        • Contact:
          • Phone Number: +385 91 588 1571
        • Principal Investigator:
          • Dominik Kralj
      • Zagreb, Croatia, 10000
        • Not yet recruiting
        • University Hospital Center Zagreb
        • Principal Investigator:
          • Zeljko Krznaric
        • Contact:
          • Phone Number: +38598355454
  • Czechia
      • Brno, Czechia, 60200
        • Not yet recruiting
        • SurGal Clinic s.r.o.
        • Principal Investigator:
          • Jan Ulbrych
        • Contact:
          • Phone Number: +420 724 101 038
      • Brno, Czechia, 615 00
        • Recruiting
        • Vojenska nemocnice Brno p.o.
        • Principal Investigator:
          • David Stepek
        • Contact:
          • Phone Number: +420 973445520
      • Slaný, Czechia, 27401
        • Recruiting
        • Etická komise Nemocnice Slaný
        • Principal Investigator:
          • Martin Peterka
        • Contact:
          • Phone Number: +420312575242
      • Zlín, Czechia, 762 75
        • Recruiting
        • Etická komise Krajské nemocnice T. Bati, a. s.
        • Principal Investigator:
          • Vladimir Kojecky
        • Contact:
          • Phone Number: +420 577 552 512
  • Denmark
      • København NV, Denmark, 2400
        • Not yet recruiting
        • Bispebjerg Hospital
        • Contact:
          • Phone Number: +45 20 41 50 16
        • Principal Investigator:
          • Martin Eefsen
  • France
      • Créteil, France, 94010
        • Recruiting
        • Henri Mondor Hospital
        • Principal Investigator:
          • Mathieu Uzzan
      • Grenoble, France, 38043
        • Recruiting
        • CHU de Grenoble Hopital Albert Michallon
        • Contact:
          • Phone Number: 04 76 76 72 32
        • Principal Investigator:
          • Clemence Lombois
      • La Roche-sur-Yon, France, 85925
        • Recruiting
        • Centre Hospitalier Departemental (CHD) Vendee
        • Contact:
          • Phone Number: +33 2 51 44 64 67
        • Principal Investigator:
          • Morgane Amil
      • Nice, France, 06202
        • Recruiting
        • Chu de Nice Hopital de L'Archet
        • Contact:
          • Phone Number: +33 4 92 03 93 66
        • Principal Investigator:
          • Adrien Nicolau
      • Pierre-Bénite, France, 69495
        • Recruiting
        • Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
        • Principal Investigator:
          • Stephane Nancey
        • Contact:
          • Phone Number: 33478864555
      • Rouen, France, 76031
        • Recruiting
        • Chu de Rouen Hopital Charles Nicolle
        • Contact:
          • Phone Number: +33 2 32 88 54 87
        • Principal Investigator:
          • Guillaume Savoye
  • Germany
      • Augsburg, Germany, 86156
        • Recruiting
        • Universitätsklinikum Augsburg, III. Medizinische Klinik Studienzentrum
        • Contact:
          • Phone Number: +49 821 400 2635
        • Principal Investigator:
          • Elisabeth Schnoy
      • Berlin, Germany, 13353
        • Recruiting
        • Charité Campus Virchow-Klinikum
        • Contact:
          • Phone Number: +49 30 450 66 53 18
        • Principal Investigator:
          • Michael Sigal
      • Brandenburg an der Havel, Germany, 14770
        • Recruiting
        • Universitätsklinikum Brandenburg GmbH
        • Principal Investigator:
          • Stefan Lueth
        • Contact:
          • Phone Number: +49 3381 411600
      • Duisburg, Germany, 47055
        • Recruiting
        • MVZ für spezialärztliche Versorgung Dr. Friedrichs GmbH
        • Principal Investigator:
          • Wolfgang Nitz
        • Contact:
          • Phone Number: +49 203 733-2385
      • Frankfurt am Main, Germany, 60590
        • Recruiting
        • Universitätsklinikum Frankfurt Goethe-Universität, Medizinische Klinik 1
        • Principal Investigator:
          • Irina Blumenstein
        • Contact:
          • Phone Number: +49 69 6301 87769
      • Frankfurt am Main, Germany, 60594
        • Not yet recruiting
        • Interdisziplinäres Crohn Colitis Centrum Rhein-Main
        • Principal Investigator:
          • Juergen Stein
      • Halle, Germany, 06108
        • Recruiting
        • Studiengesellschaft BSF Unternehmergesellschaft
        • Principal Investigator:
          • Lars Fechner
        • Contact:
          • Phone Number: 49345299760
      • Hamburg, Germany, 20251
        • Not yet recruiting
        • HaFCED e.K. - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
        • Principal Investigator:
          • Stefanie Howaldt
        • Contact:
          • Phone Number: +49 40 4232 65150
      • Hanover, Germany, 30625
        • Recruiting
        • Medizinische Hochschule Hannover
        • Principal Investigator:
          • Ursula Seidler
        • Contact:
          • Phone Number: +49 511 532 9427
      • Kiel, Germany, 24105
        • Recruiting
        • Universitatsklinikum Schleswig-Holstein
        • Principal Investigator:
          • Stefan Schreiber
        • Contact:
          • Phone Number: +4943150022202
      • München, Germany, 81675
        • Recruiting
        • Klinikum rechts der Isar der TU München
        • Contact:
          • Phone Number: +498941405797
        • Principal Investigator:
          • Matthias Treiber
      • Remscheid, Germany, 42859
        • Recruiting
        • Magen-Darm-Zentrum Remscheid
        • Contact:
          • Phone Number: +49 2191 8 90 10 50
        • Principal Investigator:
          • Eric Jörgensen
      • Ulm, Germany, 89081
        • Not yet recruiting
        • Universitätsklinikum Ulm
        • Principal Investigator:
          • Jochen Klaus
        • Contact:
          • Phone Number: 4973150044609
  • Greece
      • Athens, Greece, 11528
        • Recruiting
        • Alexandra Hospital
        • Contact:
          • Phone Number: +30 2132162387
        • Principal Investigator:
          • Spyridon Michopoulos
      • Athens, Greece, 115 27
        • Recruiting
        • General Hospital of Athens Hippokratio
        • Principal Investigator:
          • Spilios Manolakopoulos
        • Contact:
          • Phone Number: +30 2105234108
      • Athens, Greece, 11527
        • Recruiting
        • Sotiria Thoracic Diseases Hospital of Athens
        • Principal Investigator:
          • Georgios Bamias
        • Contact:
          • Phone Number: +30 2107788055
      • Athens, Greece, 10676
        • Recruiting
        • General Hospital of Athens 'Evangelismos'
        • Principal Investigator:
          • NIKOLAOS VIAZIS
        • Contact:
          • Phone Number: +306934203764
      • Heraklion, Greece, 71500
        • Recruiting
        • PAGNI-University General Hospital of Heraklion
        • Principal Investigator:
          • Ioannis Koutroubakis
        • Contact:
          • Phone Number: +302810392253
      • Ioannina, Greece, 45500
        • Recruiting
        • University Hospital of Ioannina
        • Contact:
          • Phone Number: 0030 6945546490
        • Principal Investigator:
          • Dimitrios Christodoulou
      • Nea Kifissia, Greece, 14564
        • Not yet recruiting
        • General Oncology Hospital of Kifissia "Agioi Anargiroi"
        • Principal Investigator:
          • Athanasia Tasovasili
        • Contact:
          • Phone Number: +306977246220
  • Hungary
      • Budapest, Hungary, 1036
        • Recruiting
        • Óbudai Egészségügyi Centrum
        • Contact:
          • Phone Number: 36203383272
        • Principal Investigator:
          • Robert Sike
      • Budapest, Hungary, 1088
        • Recruiting
        • Semmelweis University
        • Principal Investigator:
          • Zsolt Tulassay
        • Contact:
          • Phone Number: 36209274900
      • Budapest, Hungary, 1033
        • Recruiting
        • Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft
        • Principal Investigator:
          • Gabor Tamas Toth
        • Contact:
          • Phone Number: 36309399575
      • Gyöngyös, Hungary, 3200
        • Not yet recruiting
        • Bugat Pal Korhaz
        • Contact:
          • Phone Number: +3637312491
        • Principal Investigator:
          • Gyula Horvath
      • Gyöngyös, Hungary, 3200
        • Not yet recruiting
        • Clinexpert Gyöngyös Kft.
        • Principal Investigator:
          • Gyula Horvath
        • Contact:
          • Phone Number: +36209650290
      • Szeged, Hungary, 6725
        • Not yet recruiting
        • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
        • Contact:
          • Phone Number: +36 20 416 6008
        • Principal Investigator:
          • Klaudia Farkas
      • Székesfehérvár, Hungary, 8000
        • Recruiting
        • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
        • Contact:
          • Phone Number: 36209774818
        • Principal Investigator:
          • Roland Fejes
  • Ireland
      • Dublin, Ireland, D9
        • Recruiting
        • Beaumont Hospital, Dublin
        • Contact:
          • Phone Number: 35317974735
        • Principal Investigator:
          • Aoibhlinn O'Toole
  • Italy
      • Bologna, Italy, 40138
        • Recruiting
        • IRCCS - AOU di Bologna
        • Contact:
          • Phone Number: 0039 0512145312
        • Principal Investigator:
          • Fernando Rizzello
      • Brescia, Italy, 25124
        • Not yet recruiting
        • Fondazione Poliambulanza
        • Principal Investigator:
          • Paola Cesaro
      • Fano, Italy, 61032
        • Recruiting
        • AST Pesaro Urbino - Presidio Ospedaliero Santa Croce
        • Contact:
          • Phone Number: 0039 0721 88 2063
        • Principal Investigator:
          • Antonella Scarcelli
      • Florence, Italy, 50134
        • Recruiting
        • Azienda Ospedaliera Universitaria Careggi
        • Principal Investigator:
          • Francesca Rogai
        • Contact:
          • Phone Number: (39) 0557946284
      • Gazzi - Messina, Italy, 98125
        • Recruiting
        • A.O.U. Policlinico G. Martino
        • Contact:
          • Phone Number: +39 0902213538
        • Principal Investigator:
          • Walter Fries
      • Milan, Italy, 20142
        • Recruiting
        • Ospedale S. Paolo
        • Principal Investigator:
          • Luca Pastorelli
        • Contact:
          • Phone Number: +39 02 8184 4274
      • Modena, Italy, 41124
        • Not yet recruiting
        • Azienda Ospedaliero Universitaria
        • Contact:
          • Phone Number: +39 059 4224359
        • Principal Investigator:
          • Antonio Colecchia
      • Monserrato, Italy, 09042
        • Recruiting
        • Università di Cagliari - Presidio Policlinico Monserrato
        • Contact:
          • Phone Number: +39(070)6754621
        • Principal Investigator:
          • Massimo Fantini
      • Padova, Italy, 35128
        • Recruiting
        • Azienda Ospedale Università di Padova
        • Principal Investigator:
          • Edoardo Vincenzo Savarino
        • Contact:
          • Phone Number: +390498217749
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione IRCCS Policlinico San Matteo
        • Principal Investigator:
          • Antonio Di Sabatino
        • Contact:
          • Phone Number: 0039 0382 502973
      • Roma, Italy, 00133
        • Recruiting
        • Policlinico Tor Vergata
        • Principal Investigator:
          • Giovanni Monteleone
        • Contact:
          • Phone Number: +390620903702
      • Roma, Italy, 157
        • Not yet recruiting
        • Ospedale Sandro Pertini
        • Principal Investigator:
          • Roberta Pica
        • Contact:
          • Phone Number: +390641433308
      • Rome, Italy, 00128
        • Recruiting
        • Policlinico Universitario Campus Bio-Medico
        • Contact:
          • Phone Number: +39 06225411606
        • Principal Investigator:
          • Michele Cicala
      • Rozzano, Italy, 20089
        • Recruiting
        • Istituto Clinico Humanitas
        • Principal Investigator:
          • Alessandro Armuzzi
        • Contact:
          • Phone Number: +390282245555
      • San Donato Milanese, Italy, 20097
        • Recruiting
        • IRCCS Policlinico San Donato
        • Principal Investigator:
          • Vito Annese
        • Contact:
          • Phone Number: +390252774951
      • San Giovanni Rotondo, Italy, 71013
        • Recruiting
        • IRCCS Ospedale Casa Sollievo della Sofferenza
        • Principal Investigator:
          • Fabrizio Bossa
        • Contact:
          • Phone Number: + 39 0882 410815
      • Segrate, Italy, 20132
        • Recruiting
        • IRCCS Ospedale San Raffaele
        • Principal Investigator:
          • Silvio Danese
        • Contact:
          • Phone Number: 0039 02 26432069
      • Torino, Italy, 10126
        • Recruiting
        • A.O.U. Citta' della Salute e della Scienza di Torino
        • Contact:
          • Phone Number: +390116336223
        • Principal Investigator:
          • Davide Giuseppe Ribaldone
      • Torino, Italy, 10128
        • Recruiting
        • SC Farmacia AO Ordine Mauriziano
        • Principal Investigator:
          • Marco Daperno
        • Contact:
          • Phone Number: +390115082534
  • Japan
      • Chiba, Japan, 260-8677
        • Not yet recruiting
        • Chiba University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Jun Kato
      • Chikushino-shi, Japan, 818-8502
        • Recruiting
        • Fukuoka University Chikushi Hospital
        • Principal Investigator:
          • Takashi Hisabe
        • Contact:
          • Phone Number: 81120023812
      • Fukuoak, Japan, 810-0001
        • Not yet recruiting
        • Saiseikai Fukuoka General Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Toshiaki Ochiai
      • Hachinohe-shi, Japan, 031-8555
        • Not yet recruiting
        • Hachinohe City Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Motoji Oki
      • Hirosaki, Japan, 036-8545
        • Not yet recruiting
        • National Hospital Organization Hirosaki General Medical Center
        • Principal Investigator:
          • Yoh Ishiguro
        • Contact:
          • Phone Number: 81120023812
      • Hiroshima, Japan, 734-8551
        • Not yet recruiting
        • Hiroshima University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Ken Yamashita
      • Hiroshima, Japan, 731-0293
        • Recruiting
        • Hiroshima City North Medical Center Asa Citizens Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shinji Nagata
      • Isehara, Japan, 259-1193
        • Recruiting
        • Tokai University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Mia Fujisawa
      • Isesaki-shi, Japan, 372-0817
        • Recruiting
        • Isesaki Municipal Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takashige Masuo
      • Kagoshima, Japan, 892-0843
        • Recruiting
        • Kagoshima IBD Gastroenterology Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yohei Ono
      • Kanazawa, Japan, 920-8650
        • Not yet recruiting
        • National Hospital Organization Kanazawa Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takashi Kagaya
      • Kashiwa, Japan, 277-0871
        • Recruiting
        • Tsujinaka Hospital Kashiwanoha
        • Principal Investigator:
          • Ken Takeuchi
        • Contact:
          • Phone Number: 81120023812
      • Kitakyushu-Shi, Japan, 806 8501
        • Not yet recruiting
        • JCHO Kyushu Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takashi Hirata
      • Kofu, Japan, 400-8506
        • Not yet recruiting
        • Yamanashi Prefectural Central Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yuichiro Kojima
      • Koriyama-shi, Japan, 963-8801
        • Not yet recruiting
        • Hoshi General Hospital Foundation
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Atsushi Ishino
      • Kurume-shi, Japan, 830 8543
        • Not yet recruiting
        • Our Lady of the Snow St. Mary's Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroshi Kawano
      • Kōtoku, Japan, 135 8577
        • Not yet recruiting
        • Showa University Koto Toyosu Hospital
        • Principal Investigator:
          • Naoyuki Uragami
        • Contact:
          • Phone Number: 81120023812
      • Minatoku, Japan, 108 8642
        • Recruiting
        • Kitasato University Kitasato Institute Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kunio Asonuma
      • Mitaka, Japan, 181-8611
        • Recruiting
        • Kyorin University Hospital
        • Principal Investigator:
          • TADAKAZU HISAMATSU
        • Contact:
          • Phone Number: 81120023812
      • Morioka, Japan, 020-8505
        • Recruiting
        • Iwate Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takayuki Matsumoto
      • Nara, Japan, 630-8054
        • Recruiting
        • Nara Prefecture General Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kei Moriya
      • Nishinomiya, Japan, 663-8501
        • Recruiting
        • Hyogo College of Medicine
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shinichiro Shinzaki
      • Osaka, Japan, 530-0011
        • Recruiting
        • Infusion Clinic
        • Principal Investigator:
          • Hiroaki Ito
        • Contact:
          • Phone Number: 81120023812
      • Sapporo, Japan, 065-0033
        • Recruiting
        • Sapporo Higashi Tokushukai Hospital
        • Principal Investigator:
          • Atsuo Maemoto
        • Contact:
          • Phone Number: 81120023812
      • Sapporo, Japan, 40041
        • Recruiting
        • Tokushukai Sapporo Tokushukai Hospital
        • Principal Investigator:
          • Toshifumi Ashida
        • Contact:
          • Phone Number: 81120023812
      • Sapporo Shi Chuo Ku, Japan, 064-0919
        • Recruiting
        • Sapporo IBD Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroki Tanaka
      • Shinagawa-KU, Japan, 141-8625
        • Not yet recruiting
        • Ntt Medical Center Tokyo
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yohei Minato
      • Shinjuku-ku, Japan, 169-0073
        • Not yet recruiting
        • JHCO Tokyo Yamate Medical Center
        • Principal Investigator:
          • Masayuki Fukata
        • Contact:
          • Phone Number: 81120023812
      • Sumida-ku, Japan, 130-8575
        • Not yet recruiting
        • Tokyo Metro Bokutoh Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yohei Furumoto
      • Sunto-gun, Japan, 411-8611
        • Recruiting
        • National Hospital Organization Shizuoka Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yoshifumi Onishi
      • Toyama, Japan, 930-0194
        • Recruiting
        • Toyama University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kenji Watanabe
      • Tsu, Japan, 514-8507
        • Recruiting
        • Mie University Hospital
        • Principal Investigator:
          • Noriyuki Horiki
        • Contact:
          • Phone Number: 81120023812
      • Yokohama, Japan, 220 0041
        • Not yet recruiting
        • Matsushima Hospital
        • Principal Investigator:
          • Koichi Nakajima
        • Contact:
          • Phone Number: 81120023812
      • Ōita, Japan, 870-0033
        • Not yet recruiting
        • Oita Red Cross Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tetsuya Ueo
  • Latvia
      • Liepāja, Latvia, LV-3414
        • Recruiting
        • Liepaja Regional Hospital
        • Contact:
          • Phone Number: +37129526821
        • Principal Investigator:
          • Linda Erne
      • Riga, Latvia, LV-1002
        • Recruiting
        • Pauls Stradins Clinical Univeristy Hospital
        • Contact:
          • Phone Number: +37129253394
        • Principal Investigator:
          • Aldis Pukitis
  • Poland
      • Bydgoszcz, Poland, 85-231
        • Recruiting
        • Centrum Medyczne Kermed Renata Bojata-Bronisz i Ewa Kowalińska Sp.j.
        • Principal Investigator:
          • Patryk Korga
        • Contact:
          • Phone Number: 48 602 605 113
      • Bydgoszcz, Poland, 85-229
        • Recruiting
        • ManerMed Sp z o.o. Centrum Medyczne ,Medis
        • Principal Investigator:
          • Maria Klopocka
        • Contact:
          • Phone Number: (48)601667497
      • Krakow, Poland, 31-506
        • Recruiting
        • Topolowa Medicenter Ryszawa & Wspólnicy Sp.j.
        • Principal Investigator:
          • Zbigniew Wylegala
        • Contact:
          • Phone Number: (+48) 606 672 789
      • Krakow, Poland, 30-363
        • Recruiting
        • Centrum Medyczne Plejady Magdalena Celińska-Löwenhoff, Michał Żołnowski sp.k
        • Principal Investigator:
          • Monika Augustyn
        • Contact:
          • Phone Number: 48 604054157
      • Krakow, Poland, 31-011
        • Recruiting
        • Centrum Nowoczesnych Terapii "Dobry Lekarz" sp. z o. o.
        • Principal Investigator:
          • Malgorzata Sladek
        • Contact:
          • Phone Number: +48 602 559 913
      • Lodz, Poland, 91 034
        • Recruiting
        • Med-GASTR SP. Z O.O., SP.K.
        • Principal Investigator:
          • Arkadiusz Mamos
        • Contact:
          • Phone Number: 48502357277
      • Lodz, Poland, 90-752
        • Recruiting
        • Ip Clinic Sp. Z O. O.
        • Principal Investigator:
          • Cezary Rudnicki
        • Contact:
          • Phone Number: (48)518 808 864
      • Lublin, Poland, 20-582
        • Recruiting
        • Medrise sp. z o.o
        • Principal Investigator:
          • Wit Danilkiewicz
        • Contact:
          • Phone Number: (48) 795 404 502
      • Opole, Poland, 45 819
        • Recruiting
        • Twoja Przychodnia Opolskie Centrum Medyczne
        • Principal Investigator:
          • Marzena Kwinto
        • Contact:
          • Phone Number: (+48) 690 548 825
      • Poznan, Poland, 60-324
        • Recruiting
        • Twoja Przychodnia PCM
        • Contact:
          • Phone Number: +48 724 444 299
        • Principal Investigator:
          • Ewa Furmanowska-Ladorska
      • Sopot, Poland, 81-756
        • Recruiting
        • Endoskopia Sp. z.o.o.
        • Principal Investigator:
          • Marek Horynski
        • Contact:
          • Phone Number: +48 501011879
      • Torun, Poland, 87-100
        • Recruiting
        • GASTROMED Sp. z o.o.
        • Principal Investigator:
          • Adam Kopon
        • Contact:
          • Phone Number: (48) 501 028 551
      • Tychy, Poland, 43-100
        • Not yet recruiting
        • H-T. Centrum Medyczne-Endoterapia
        • Principal Investigator:
          • Tomasz Romanczyk
        • Contact:
          • Phone Number: +48 515342221
      • Wadowice, Poland, 34-100
        • Recruiting
        • NZOZ FOR MED sp. z o.o.
        • Principal Investigator:
          • Beata Mroziak
        • Contact:
          • Phone Number: (+48) 531 555 103
      • Warsaw, Poland, 04-501
        • Recruiting
        • WIP Warsaw IBD Point Profesor Kierkus
        • Principal Investigator:
          • Jaroslaw Kierkus
        • Contact:
          • Phone Number: (48) 500 111 648
      • Wroclaw, Poland, 52-416
        • Recruiting
        • Centrum Medyczne Oporow
        • Principal Investigator:
          • Radoslaw Kempinski
        • Contact:
          • Phone Number: (48) 604 911 743
      • Wroclaw, Poland, 53-611
        • Recruiting
        • Melita Medical
        • Principal Investigator:
          • Jaroslaw Leszczyszyn
        • Contact:
          • Phone Number: (+48) 661 302 302
      • Wroclaw, Poland, 53-149
        • Recruiting
        • VISTAMED
        • Contact:
          • Phone Number: +48 600 411 536
        • Principal Investigator:
          • Bernadeta Frysna
  • Romania
      • Bucharest, Romania, 020125
        • Recruiting
        • Colentina Clinical Hospital
        • Principal Investigator:
          • Bogdan Mateescu
        • Contact:
          • Phone Number: +40722588451
      • Bucharest, Romania, 010825
        • Not yet recruiting
        • Dr.Carol Davila Emergency University Central Military Hospital
        • Contact:
          • Phone Number: +40723601034
        • Principal Investigator:
          • Sandica Bucurica
      • Bucharest, Romania, 012015
        • Recruiting
        • S.C. Centrul Medical Medicum SRL
        • Principal Investigator:
          • Theodor-Alexandru Voiosu
        • Contact:
          • Phone Number: +40726732764
      • Bucharest, Romania, 50098
        • Recruiting
        • Emergency University Hospital
        • Contact:
          • Phone Number: +40722546405
        • Principal Investigator:
          • Lucian Negreanu
      • Cluj-Napoca, Romania, 400162
        • Recruiting
        • Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
        • Contact:
          • Phone Number: +40744840437
        • Principal Investigator:
          • Cristina Pojoga
      • Ploieşti, Romania, 100032
        • Recruiting
        • Valahia Medical Center SRL
        • Contact:
          • Phone Number: +40725218280
        • Principal Investigator:
          • George Stancu
      • Timișoara, Romania, 300002
        • Recruiting
        • S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
        • Contact:
          • Phone Number: 40722410712
        • Principal Investigator:
          • Adrian Goldis
  • Serbia
      • Belgrade, Serbia, 11000
        • Recruiting
        • Military Medical Academy
        • Contact:
          • Phone Number: +381 641640231
        • Principal Investigator:
          • Nebojsa Manojlovic
      • Belgrade, Serbia, 11000
        • Recruiting
        • Clinical Center " Dr Dragisa Misovic Dedinje"
        • Contact:
          • Phone Number: +381641699494
        • Principal Investigator:
          • Zoran Milenkovic
      • Belgrade, Serbia, 11000
        • Recruiting
        • Clinical Hospital Center Zvezdara
        • Contact:
          • Phone Number: +381 64 4595040
        • Principal Investigator:
          • Srdjan Markovic
      • Belgrade, Serbia, 11000
        • Recruiting
        • Clinical Hospital Center Bezanijska Kosa
        • Contact:
          • Phone Number: +381621123960
        • Principal Investigator:
          • Igor Jovanovic
      • Belgrade, Serbia, 11000
        • Not yet recruiting
        • Clinical Hospital Centre Zemun
        • Contact:
          • Phone Number: +381 642580244
        • Principal Investigator:
          • Aleksandar Pavlovic
      • Novi Sad, Serbia, 21000
        • Recruiting
        • Clinical Center of Vojvodina
        • Contact:
          • Phone Number: +381 638050381
        • Principal Investigator:
          • Tatiana Jocic
      • Pančevo, Serbia, 26101
        • Recruiting
        • General Hospital Pancevo
        • Contact:
          • Phone Number: +381637571070
        • Principal Investigator:
          • Natasa Mijic Mitosevic
      • Zrenjanin, Serbia, 23000
        • Recruiting
        • General Hospital "Djordje Joanovic"
        • Contact:
          • Phone Number: +381692269372
        • Principal Investigator:
          • Dusan Slankamenac
  • Spain
      • Barcelona, Spain, 8022
        • Recruiting
        • Centro Medico Teknon - DIGESTIVO
        • Principal Investigator:
          • Miquel Sans Cuffi
        • Contact:
          • Phone Number: 680803738
      • Ciudad Real, Spain, 13700
        • Recruiting
        • Hospital General Tomelloso
        • Contact:
          • Phone Number: +34926525800
        • Principal Investigator:
          • Alfredo Lucendo Villarin
      • Córdoba, Spain, 14004
        • Recruiting
        • Hospital Universitario Reina Sofia Comite Etico
        • Contact:
          • Phone Number: +34 957-011-297 C: 511-297
        • Principal Investigator:
          • Eva Iglesias Flores
      • Huelva, Spain, 21005
        • Recruiting
        • Hospital Universitario Juan Ramón Jiménez
        • Contact:
          • Phone Number: +34656952460
        • Principal Investigator:
          • Hector Pallares Manrique
      • Las Palmas de GC, Spain, 35019
        • Recruiting
        • Hospital Universitario de Gran Canaria Doctor Negrin
        • Principal Investigator:
          • Daniel Ceballos Santos
        • Contact:
          • Phone Number: +34928284414
      • Madrid, Spain, 28046
        • Recruiting
        • Hospital Universitario La Paz
        • Principal Investigator:
          • MARIA DOLORES MARTIN ARRANZ
        • Contact:
          • Phone Number: +34912071350
      • Santiago de Compostela, Spain, 15706
        • Recruiting
        • Hospital Clinico Universitario de Santiago de Compostela
        • Contact:
          • Phone Number: +34 981 981 372
        • Principal Investigator:
          • Manuel Francisco Barreiro de Acosta
      • Seville, Spain, 41009
        • Recruiting
        • Hospital Universitario Virgen Macarena
        • Principal Investigator:
          • Federico Arguelles Arias
        • Contact:
          • Phone Number: +34627 621 785
      • Valencia, Spain, 46026
        • Recruiting
        • CEIM Hospital Universitario y Politecnico la Fe
        • Principal Investigator:
          • Marisa Iborra Colomino
        • Contact:
          • Phone Number: +34961244000
  • Turkey (Türkiye)
      • Ankara, Turkey (Türkiye), 6560
        • Not yet recruiting
        • Gazi University Medical Faculty Gazi Hospital
        • Principal Investigator:
          • Tarkan Karakan
        • Contact:
          • Phone Number: +90505 319 22 57
      • Izmir, Turkey (Türkiye), 35100
        • Not yet recruiting
        • Ege Universitesi Hastanesi
        • Principal Investigator:
          • Nalan Unal
        • Contact:
          • Phone Number: +905057823808
      • Malatya, Turkey (Türkiye), 44280
        • Not yet recruiting
        • İnönü Üniversitesi Tıp Fakültesi
        • Contact:
          • Phone Number: +905326853066
        • Principal Investigator:
          • Yasir Furkan Cagin
      • Mersin, Turkey (Türkiye), 33169
        • Not yet recruiting
        • Mersin University Medical Faculty Hospital
        • Principal Investigator:
          • Engin Altintas
        • Contact:
          • Phone Number: +90532 614 52 76
  • United States
    • Arizona
      • Chandler, Arizona, United States, 85225
        • Not yet recruiting
        • AZ Gastro Care - Chandler
        • Contact:
          • Phone Number: 480-716-5392
        • Principal Investigator:
          • Jae Kim
    • Arkansas
      • Little Rock, Arkansas, United States, 72211
        • Not yet recruiting
        • Preferred Research Partners
        • Contact:
          • Phone Number: 501-553-9987
        • Principal Investigator:
          • John Baber
      • Little Rock, Arkansas, United States, 72205
        • Recruiting
        • Applied Research Center of Arkansas
        • Principal Investigator:
          • Angelo Coppola
        • Contact:
          • Phone Number: 501-954-7822
    • California
      • Chula Vista, California, United States, 91910
        • Recruiting
        • Erick Alayo Medical Corp/Gastro SB Clinic
        • Principal Investigator:
          • Erick Alayo
        • Contact:
          • Phone Number: 619-513-3372
      • Coronado, California, United States, 92118
        • Recruiting
        • Southern California GI and Liver Centers (SCLC)
        • Contact:
          • Phone Number: 619-522-0330
        • Principal Investigator:
          • Tarek Hassanein
      • Garden Grove, California, United States, 92845
        • Recruiting
        • Valley View Research
        • Principal Investigator:
          • Michael Kurtz
        • Contact:
          • Phone Number: 855-229-1665
      • Lancaster, California, United States, 93534
        • Recruiting
        • Om Research, LLC
        • Principal Investigator:
          • Jatinder Pruthi
        • Contact:
          • Phone Number: 661-388-2239
      • Los Alamitos, California, United States, 90720-3433
        • Recruiting
        • United Medical Doctors
        • Contact:
          • Phone Number: 562-430-4449
        • Principal Investigator:
          • Seyedehsan Navabi
      • Orange, California, United States, 92868-4402
        • Recruiting
        • Clinnova Research
        • Principal Investigator:
          • Amit Bhanvadia
        • Contact:
          • Phone Number: 949-889-0249
      • Rancho Cucamonga, California, United States, 91730-4850
        • Recruiting
        • Prospective Research Innovations
        • Principal Investigator:
          • Tarek Ezzeddine
        • Contact:
          • Phone Number: 707-940-7767
      • Thousand Oaks, California, United States, 91360
        • Recruiting
        • Clinical Trials Management Services, LLC
        • Contact:
          • Phone Number: 1-805-906-7800
        • Principal Investigator:
          • MAHENDRA PATEL
      • Victorville, California, United States, 92395
        • Recruiting
        • Om Research LLC
        • Contact:
          • Phone Number: 661-388-2239
        • Principal Investigator:
          • Thomas Nguyen
    • Colorado
      • Colorado Springs, Colorado, United States, 80907-6262
        • Recruiting
        • Peak Gastroenterology Associates
        • Principal Investigator:
          • Bhaktasharan Patel
        • Contact:
          • Phone Number: 719-362-2281
    • Connecticut
      • Hamden, Connecticut, United States, 06518-3602
        • Recruiting
        • Medical Research Center of Connecticut, LLC
        • Contact:
          • Phone Number: 203-281-5161
        • Principal Investigator:
          • Paul Feuerstadt
    • Florida
      • Clermont, Florida, United States, 34711
        • Not yet recruiting
        • Novum Research, LLC
        • Contact:
          • Phone Number: 352-558-8655
        • Principal Investigator:
          • Edriss Estime
      • Doral, Florida, United States, 33126
        • Not yet recruiting
        • I.V.A.M. Clinical & Investigational Center, LLC
        • Contact:
          • Phone Number: 786-803-8002
        • Principal Investigator:
          • Jorge M. Venereo
      • Lakewood Rch, Florida, United States, 34211
        • Not yet recruiting
        • Florida Research Institute
        • Contact:
          • Phone Number: 941-727-7772
        • Principal Investigator:
          • Manuel Rodriguez
      • Miami, Florida, United States, 33173
        • Recruiting
        • Well Pharma Medical Research Corp.
        • Principal Investigator:
          • Eddie Armas
        • Contact:
          • Phone Number: 305-665-4818
      • Miami, Florida, United States, 33176
        • Not yet recruiting
        • Reserka
        • Contact:
          • Phone Number: 786-785-6223
        • Principal Investigator:
          • Victor Pina
      • Orange Park, Florida, United States, 32073-4752
        • Not yet recruiting
        • Digestive Disease Consultants DDCJAX
        • Principal Investigator:
          • Samir Habashi
        • Contact:
          • Phone Number: 904-406-0633
      • Orlando, Florida, United States, 32803
        • Not yet recruiting
        • AdventHealth Orlando
        • Principal Investigator:
          • Jennifer Seminerio Diehl
      • Orlando, Florida, United States, 32803-1248
        • Recruiting
        • Orlando Health Digestive Health Institute
        • Principal Investigator:
          • Udayakumar Navaneethan
        • Contact:
          • Phone Number: 216-502-0981
      • Tampa, Florida, United States, 33609
        • Recruiting
        • GCP Clinical Research, LLC
        • Principal Investigator:
          • Alan Weintraub
        • Contact:
          • Phone Number: 813-240-9734
      • Tampa, Florida, United States, 33607
        • Recruiting
        • Nodal Medical Center
        • Contact:
          • Phone Number: 813-374-0568
        • Principal Investigator:
          • Leopoldo Grauer
      • Tampa, Florida, United States, 33614
        • Recruiting
        • International Center for Research LLC
        • Principal Investigator:
          • Angel Rosario
        • Contact:
          • Phone Number: 813-930-8816
      • Tampa, Florida, United States, 33607
        • Recruiting
        • Research Bay,Inc.
        • Contact:
          • Phone Number: 813-304-1265
        • Principal Investigator:
          • Mina Elnemr
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Not yet recruiting
        • Northwestern University
        • Contact:
          • Phone Number: 312-695-5878
        • Principal Investigator:
          • Keith Summa
      • Oak Lawn, Illinois, United States, 60453-3754
        • Recruiting
        • Avicenna Clinical Research - SW Gastroenterology
        • Contact:
          • Phone Number: 708-499-5678
        • Principal Investigator:
          • Charles Berkelhammer
    • Louisiana
      • Metairie, Louisiana, United States, 70006
        • Not yet recruiting
        • Clinical Trials Management, LLC
        • Contact:
          • Phone Number: 504-455-1310
        • Principal Investigator:
          • David Dulitz
    • Michigan
      • Wyoming, Michigan, United States, 49519
        • Recruiting
        • Gastroenterology Associates of Western Michigan, P.L.C.
        • Principal Investigator:
          • Allan Coates
        • Contact:
          • Phone Number: 616-328-5344
    • New York
      • Brooklyn, New York, United States, 11215
        • Recruiting
        • Ellipsis Research Group
        • Principal Investigator:
          • Jorge Serje
        • Contact:
          • Phone Number: 347-422-0317
      • Jackson Heights, New York, United States, 11372
        • Recruiting
        • Smart Medical Research - Jackson Heights
        • Principal Investigator:
          • Gulam Khan
        • Contact:
          • Phone Number: 718-305-1900
      • New York, New York, United States, 10012-3645
        • Recruiting
        • Pioneer Clinical Research NY
        • Principal Investigator:
          • Murray Orbuch
        • Contact:
          • Phone Number: 917-977-0900
      • Utica, New York, United States, 13502
        • Recruiting
        • Digestive Disease Medicine of Central New York
        • Contact:
          • Phone Number: 315-624-7035
        • Principal Investigator:
          • Harvey Allen
    • North Carolina
      • Chapel Hill, North Carolina, United States, 27599
        • Recruiting
        • University of North Carolina
        • Principal Investigator:
          • Animesh Jain
        • Contact:
          • Phone Number: 919-445-3880
    • Ohio
      • Cincinnati, Ohio, United States, 45219
        • Recruiting
        • GCGA Physicians, LLC dba / Gastro Health Research
        • Principal Investigator:
          • Pradeep Bekal
        • Contact:
          • Phone Number: 513-872-4549
      • Lima, Ohio, United States, 45801
        • Recruiting
        • Nexgen Research
        • Principal Investigator:
          • Nonso Ezema
        • Contact:
          • Phone Number: 419-516-0954 Ext 105
    • Texas
      • Baytown, Texas, United States, 77521
        • Recruiting
        • Inquest Clinical Research
        • Principal Investigator:
          • Haider Afzal
        • Contact:
          • Phone Number: 281-428-8203
      • Edinburg, Texas, United States, 78539
        • Recruiting
        • DHR Health Gastroenterology - Edinburg
        • Contact:
          • Phone Number: 956-362-2356
        • Principal Investigator:
          • Murthy Badiga
      • Houston, Texas, United States, 77030
        • Recruiting
        • Baylor College of Medicine
        • Contact:
          • Phone Number: 713-798-7616
        • Principal Investigator:
          • Jason Hou
      • Houston, Texas, United States, 77043
        • Recruiting
        • Intergrity Research
        • Principal Investigator:
          • Mouhamad Al-Sabbagh
        • Contact:
          • Phone Number: 832-860-0720
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • Gastroenterology Research of San Antonio
        • Contact:
          • Phone Number: 210-615-3848
        • Principal Investigator:
          • Nicholas Martinez
      • Tyler, Texas, United States, 75701
        • Recruiting
        • Tyler Research Institute
        • Principal Investigator:
          • George Duvall
        • Contact:
          • Phone Number: 903-630-6211
    • Utah
      • Ogden, Utah, United States, 84403
        • Recruiting
        • Care Access-Ogden
        • Principal Investigator:
          • Chad Gonzales
        • Contact:
          • Phone Number: 801-614-0010
      • Ogden, Utah, United States, 84405
        • Recruiting
        • Advanced Research Institute - South Ogden
        • Contact:
          • Phone Number: 801-409-2040
        • Principal Investigator:
          • John Lowe
    • Washington
      • Seattle, Washington, United States, 98195
        • Not yet recruiting
        • University of Washington School Medicine
        • Principal Investigator:
          • Scott Lee
        • Contact:
          • Phone Number: 206-543-3500

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have had an established diagnosis of UC of ≥3 months in duration before baseline.
  • Have moderately to severely active UC as assessed by the UC disease activity score.
  • Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators).
  • Are on a stable dose of certain oral UC medications (including corticosteroids).
  • Must meet contraception requirements.

Exclusion Criteria:

  • Have received anti-interleukin (IL)-23p19 or anti-IL-12p40 antibodies in the past.
  • Have experienced a thrombotic event within 24 weeks before baseline.
  • Have a current diagnosis of Crohn's Disease or certain other inflammatory gastrointestinal diseases.
  • Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study.
  • Have a history of certain adenomas, dysplasia's, or malignancies.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Eltrekibart + Placebo
Participants will receive eltrekibart with placebo, eltrekibart or mirikizumab.
Drug: Eltrekibart
Administered
Other Names:
  • LY3041658
Drug: Mirikizumab
Administered
Other Names:
  • LY3074828
Drug: Placebo
Administered
Experimental: Mirikizumab + Placebo
Participants will receive mirikizumab and placebo or mirikizumab.
Drug: Mirikizumab
Administered
Other Names:
  • LY3074828
Drug: Placebo
Administered
Experimental: Eltrekibart + Mirikizumab
Participants will receive eltrekibart and mirikizumab in combination or separately as monotherapy.
Drug: Eltrekibart
Administered
Other Names:
  • LY3041658
Drug: Mirikizumab
Administered
Other Names:
  • LY3074828
Experimental: Placebo
Participants will receive placebo or mirikizumab.
Drug: Mirikizumab
Administered
Other Names:
  • LY3074828
Drug: Placebo
Administered

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants Achieving Clinical Remission
Time Frame: Week 12
Percentage of Participants Achieving Clinical Remission
Week 12

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants Achieving Clinical Response
Time Frame: Week 12
Percentage of Participants Achieving Clinical Response
Week 12
Percentage of Participants Achieving Endoscopic Improvement
Time Frame: Week 12
Percentage of Participants Achieving Endoscopic Improvement
Week 12
Percentage of Participants Achieving Endoscopic Remission
Time Frame: Week 12
Percentage of Participants Achieving Endoscopic Remission
Week 12
Percentage of Participants Achieving Clinical Remission
Time Frame: Week 52
Percentage of Participants Achieving Clinical Remission
Week 52
Percentage of Participants Achieving Histologic-Endoscopic Mucosal Improvement
Time Frame: Week 12
Percentage of Participants Achieving Histologic-Endoscopic Mucosal Improvement
Week 12
Change From Baseline to Week 12 in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
Time Frame: Baseline, Week 12
Change From Baseline to Week 12 in IBDQ Total Score
Baseline, Week 12
Pharmacokinetics (PK): Trough concentrations at Steady State (Ctrough ss) of Eltrekibart
Time Frame: Week 12
PK: Ctrough ss of Eltrekibart
Week 12
PK: Ctrough ss of Mirikizumab
Time Frame: Week 12
PK: Ctrough ss of Mirikizumab
Week 12

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 10, 2024

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

September 1, 2028

Study Registration Dates

First Submitted

September 13, 2024

First Submitted That Met QC Criteria

September 13, 2024

First Posted (Actual)

September 19, 2024

Study Record Updates

Last Update Posted (Actual)

April 20, 2026

Last Update Submitted That Met QC Criteria

April 17, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 18751
  • I7P-MC-DSAG (Other Identifier: Eli Lilly and Company)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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