Socket Shield Technique With CGF and Xenograft for Immediate Implants (CGF)

April 8, 2026 updated by: Huda Ayman Alrifai, Cairo University

Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique

This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

This study is designed as a prospective case series to evaluate the effectiveness of combining concentrated growth factors (CGF) and xenograft with the socket shield technique (SST) during immediate implant placement in the maxillary esthetic region.

Post-extraction alveolar ridge resorption, particularly of the buccal bone plate, represents a significant challenge in achieving optimal esthetic outcomes. The socket shield technique has been introduced to preserve the buccal bone by retaining the labial portion of the root, thereby minimizing post-extraction resorption. However, immediate implant placement is often associated with the presence of a gap between the implant surface and the socket wall, known as the "jumping gap," which may compromise implant stability and osseointegration.

To enhance bone regeneration within this gap, bone grafting materials are commonly utilized. Concentrated growth factors (CGF), an autologous platelet concentrate, have demonstrated the ability to promote angiogenesis, osteogenesis, and soft tissue healing through the sustained release of growth factors. When combined with xenograft, which provides an osteoconductive scaffold, this approach may improve bone regeneration and implant integration.

In this study, eligible patients requiring immediate implant placement in the esthetic zone will undergo partial extraction therapy using the socket shield technique. Implants will be placed immediately after extraction, and CGF will be prepared from the patient's venous blood and mixed with xenograft to form a "sticky bone" graft, which will be applied to fill the jumping gap.

Radiographic evaluation will be performed using cone-beam computed tomography (CBCT) at 2 weeks and 6 months postoperatively to assess crestal bone level changes. Implant stability will be measured using resonance frequency analysis (Osstell device) and expressed as implant stability quotient (ISQ) values.

The findings of this study are expected to provide clinical and radiographic evidence regarding the effectiveness of combining CGF and xenograft with the socket shield technique in enhancing bone regeneration and improving outcomes of immediate implant placement in the esthetic zone.

Study Type

Interventional

Enrollment (Estimated)

7

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypt, 11553
        • Faculty of Dentistry, Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion criteria:

  • Age ≥18 years old. (Younis, W., & El-Rashidy, A. 2020).
  • Both male and female patients.
  • Maxillary, anterior and premolar segments.

Exclusion Criteria:

  • A medical history that contraindicates oral surgical treatment such as (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous bisphosphonates).
  • Presence of active or untreated periodontal disease.
  • Vertical root fractures involving the buccal aspect.
  • Tooth /teeth with horizontal fractures below bone level.
  • Tooth /teeth with external or internal resorption.
  • Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Socket Shield Technique with CGF and Xenograft in Immediate Implant Placement
Participants will undergo immediate implant placement in the esthetic zone using the socket shield technique. Following partial extraction therapy, implants will be placed immediately, and the jumping gap will be filled using a combination of concentrated growth factors (CGF) and xenograft prepared as "sticky bone." Clinical and radiographic follow-up will be conducted over a 6-month period to evaluate crestal bone levels and implant stability.
Procedure: Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft
The procedure involves partial extraction therapy using the socket shield technique, where the buccal portion of the root is preserved to maintain the alveolar bone. Immediate implant placement is performed into the extraction socket. Concentrated growth factors (CGF) are prepared from the patient's autologous blood via centrifugation and combined with xenograft to form a "sticky bone" graft. This graft is placed in the jumping gap between the implant and socket wall to enhance bone regeneration and healing. Implant stability will be measured using resonance frequency analysis (Osstell), and radiographic evaluation will be performed using CBCT.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
crestal bone level
Time Frame: 2 weeks, and 6 months postoperatively
Evaluation of changes in crestal bone level around the dental implant using cone-beam computed tomography (CBCT). Measurements will be taken from a fixed reference point on the implant to the first bone-to-implant contact recorded in millimeters (mm)
2 weeks, and 6 months postoperatively

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Implant Stability (ISQ Values)
Time Frame: Immediate postoperative, and at 6 months
Implant stability will be assessed using resonance frequency analysis with the Osstell device and recorded as Implant Stability Quotient (ISQ). ISQ values range from 1 to 100, where higher values indicate greater implant stability and a better outcome.
Immediate postoperative, and at 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Investigators

  • Study Director: Abdelmoez Mohamed El-Sharkawy, Associate Professor, Cairo University
  • Study Chair: Tarek I.A El-Ghareeb, PHD Holder, Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 5, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

December 30, 2026

Study Registration Dates

First Submitted

April 3, 2026

First Submitted That Met QC Criteria

April 3, 2026

First Posted (Actual)

April 9, 2026

Study Record Updates

Last Update Posted (Actual)

April 13, 2026

Last Update Submitted That Met QC Criteria

April 8, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • OMFS-3-3-20

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe