Effect of Mandala Coloring on Nausea, Fatigue, and Well-Being in Chemotherapy Patients (MANDALACHEMO)

May 6, 2026 updated by: Adile Nese, University of Gaziantep

The Effect of Mandala Coloring on Nausea, Vomiting, Fatigue, and Psychological Well-Being in Cancer Patients Receiving Chemotherapy

This study aims to evaluate the effect of mandala coloring on nausea, vomiting, fatigue, and psychological well-being in cancer patients receiving chemotherapy. The intervention involves guided mandala coloring sessions applied during chemotherapy cycles. The outcomes will be assessed using standardized scales measuring symptom severity and psychological well-being before and after the intervention.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This study is a clinical trial designed to investigate the effects of mandala coloring on nausea, vomiting, fatigue, and psychological well-being in cancer patients receiving chemotherapy. Chemotherapy is commonly associated with both physical and psychological side effects that negatively impact patients' quality of life.

The intervention consists of structured mandala coloring sessions conducted during chemotherapy cycles. Participants will perform the coloring activity in a calm and appropriate clinical environment. No pharmacological or additional psychological interventions will be applied during the study period.

Outcome measures include the severity of nausea, vomiting, and fatigue, as well as psychological well-being levels, assessed using validated scales at baseline and after the intervention. Differences in these outcomes will be analyzed to evaluate the effectiveness of the mandala coloring intervention.

The study is expected to provide evidence regarding low-cost, non-pharmacological supportive care methods that may improve symptom management and psychological health in chemotherapy patients.

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Study Type

Interventional

Enrollment (Actual)

85

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Şehitkamil
      • Gaziantep, Şehitkamil, Turkey (Türkiye), 27000
        • Gaziantep University Vocational School of Health Services

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Adult patients diagnosed with cancer Patients receiving chemotherapy treatment Age 18 years and older Patients who are able to communicate verbally Patients who agree to participate in the study and sign informed consent form Patients without cognitive impairment

Exclusion Criteria:

  • Patients with severe psychiatric disorders Patients with visual or cognitive impairments preventing participation in mandala coloring Patients in critical clinical condition or intensive care unit Patients who refuse to continue participation Patients receiving additional concurrent psychological interventions

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: The effect of mandala practice on nausea, vomiting, and fatigue
Cancer patients receiving chemotherapy in this group participated in a structured mandala painting intervention in addition to standard care. The intervention was applied during chemotherapy infusion and continued within the first 24 hours after treatment. Patients engaged in individual coloring activities using standardized mandala templates in a calm environment aimed at promoting relaxation and reducing symptom burden.
Other: Mandala Coloring Intervention
Participants in the intervention group performed a structured mandala coloring activity designed to promote relaxation and reduce chemotherapy-related symptoms. Pre-designed mandala patterns and colored pencils were provided. The session was conducted in a quiet environment and lasted approximately 20-30 minutes. The intervention was applied once. Outcomes including nausea, vomiting, fatigue, and psychological well-being were assessed within 24 hours after the intervention.
No Intervention: Control: Standard Care
Patients in this group received standard chemotherapy care only without any additional non-pharmacological intervention. Outcomes such as nausea, vomiting, fatigue, and psychological well-being were assessed for comparison with the experimental group.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The Effect of Mandala Coloring on Nausea, Vomiting, Fatigue, and Psychological Well-Being in Cancer Patients Receiving Chemotherapy
Time Frame: Within 24 hours after the intervention
Nausea and vomiting severity were assessed using the Rhodes Index of Nausea, Vomiting, and Retching (RINVR). Fatigue levels were measured using a standardized fatigue scale, and psychological well-being was assessed using a validated psychological well-being scale. Outcome measures were compared between the mandala painting group and the control group before and within 24 hours after the intervention.
Within 24 hours after the intervention
The effects of mandala painting on nausea, vomiting, fatigue, and psychological well-being in cancer patients undergoing chemotherapy.
Time Frame: 24 hours after intervention

Fatigue Severity Questionnaire: The fatigue severity scale is a unidimensional questionnaire with a total score of 16 on a seven-point Likert scale, and higher total scores indicate greater fatigue.

Psychological Well-being Scale: The scale consists of 8 items and is a 7-point Likert type. The scale is single-dimensional, with a minimum score of 8 and a maximum score of 56. Higher scores on the scale indicate higher overall psychological well-being.
24 hours after intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Gaziantep

Investigators

  • Principal Investigator: Adile Neşe, University of Gaziantep

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Actual)

March 15, 2026

Study Completion (Actual)

April 15, 2026

Study Registration Dates

First Submitted

April 17, 2026

First Submitted That Met QC Criteria

May 6, 2026

First Posted (Actual)

May 12, 2026

Study Record Updates

Last Update Posted (Actual)

May 12, 2026

Last Update Submitted That Met QC Criteria

May 6, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Mandala Coloring Chemotherapy

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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