Effect of Korean Ginseng Extract on Fatigue

May 15, 2026 updated by: Chien-Wen Hou, University of Taipei

Effect ofKorean Ginseng Extract on Fatigue

This study evaluated whether eight weeks of Korean ginseng extract supplementation could affect exercise performance, body composition, and selected blood-based physiological markers in healthy adults.

A total of 60 healthy adults aged 20 to 50 years were recruited and randomly assigned to either a Korean ginseng extract group or a placebo group in a double-blind, placebo-controlled design. Participants consumed one 10 mL packet of Korean ginseng extract or placebo daily for eight weeks. Assessments were performed before and after the intervention. Outcome measures included exercise performance tests, body composition, endocrine markers, inflammatory markers, oxidative stress markers, immune cell indices, and blood cell counts.

Forty-nine participants completed the post-intervention assessments. The study was approved by the University of Taipei Institutional Review Board under approval number IRB-2023-011.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
    • Taipei City
      • Taipei, Taipei City, Taiwan, 111
        • Institute of Sports Sciences, University of Taipei

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy adults aged 20 to 50 years.
  • Able and willing to participate in the study.
  • Able to provide written informed consent.

Exclusion Criteria:

  • Allergy to ginseng products.
  • History of cardiovascular disease, asthma, diabetes, liver disease, kidney disease, arrhythmia, or other chronic diseases.
  • Current use of medications for chronic diseases.
  • Habitual use of ginseng or other traditional Chinese medicine-related supplements.
  • Pregnancy or breastfeeding.
  • Menopausal women.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Korean Ginseng Extract Group
Participants received one 10 mL packet of Korean ginseng extract daily for eight weeks.
Dietary supplement: Korean Ginseng Extract
Korean ginseng extract supplement, provided as one 10 mL packet daily for eight weeks. The supplement contained ginseng extract, water, and fructooligosaccharides.
Placebo Comparator: Placebo Group
Participants received one 10 mL packet of placebo daily for eight weeks. The placebo was designed to have a similar taste and appearance to the Korean ginseng extract supplement.
Other: Placebo
Placebo supplement, provided as one 10 mL packet daily for eight weeks. The placebo was designed to have a similar taste and appearance to the Korean ginseng extract supplement and contained water, maltodextrin, fructooligosaccharides, and casein phosphopeptide.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Biceps Strength
Time Frame: Baseline and 8 weeks
Change in biceps isokinetic strength from baseline to after eight weeks of supplementation, assessed using an isokinetic dynamometer.
Baseline and 8 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in VO2max
Time Frame: Baseline and 8 weeks
Change in maximal oxygen uptake from baseline to after eight weeks of supplementation, assessed using a cycle ergometer and portable gas analysis system.
Baseline and 8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Taipei

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 27, 2023

Primary Completion (Actual)

April 9, 2024

Study Completion (Actual)

April 9, 2024

Study Registration Dates

First Submitted

May 10, 2026

First Submitted That Met QC Criteria

May 10, 2026

First Posted (Actual)

May 15, 2026

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IRB-2023-01l

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be shared because the informed consent form did not include a specific plan for sharing individual-level data with other researchers, and participant confidentiality will be protected.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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