Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT

To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.

Study Overview

• Status: Not yet recruiting
• Conditions: Intraocular Pressure; Keratoconus
• Intervention / Treatment: Device: Corvis Machine

Detailed Description

This study will be prospective study. 50 Patients will be included who will undergo corneal cross linking from the out-patient clinic of Tanta University hospital between December 2025 and December 2026 will be included in the study .

Patient with age 19 till 35 years old will be included

Patient with Corneal scarring, Previous corneal infections, Minimum corneal thickness at the thinnest location less than 400 µm, History of uveitis or ocular allergy and Pre-existing glaucoma will be excluded from the study

All patient will undergo full ophthalmological examination. including best corrected visual acuity, degree of myopia , average kertometry and intraocular pressure will be measured before and after cross linkage with three different techniques including Shiotz tonometry, appalanation tonometry and CORVIS machine

• Study Type: Interventional
• Enrollment (Estimated): 1
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Tamer Ibrahim, Ass professor of ophthalmology; Phone Number: +201001243049; Email: dinasabry71@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Patients who will corneal cross linking for mild degree of keratoconus, age between 19 and 35 years old

Exclusion Criteria:

• Corneal scarring.
• Previous corneal infections.
• Minimum corneal thickness at the thinnest location less than 400 µm.
• History of uveitis or ocular allergy.
• Pre-existing glaucoma.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Measuring the intraocular pressure after cross linking; Measuring the intraocular pressure by using different techniques after corneal cross linking	Device: Corvis Machine; Measuring the intraocular pressure

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Intraocular pressure will be measured by using Corvis CT before cross linking and one month after cross linking	Recording the intraocular pressure	Through the end of the study in approximately one year

Collaborators and Investigators

• Sponsor: Tanta University

Study record dates

Study Major Dates

• Study Start (Estimated): July 10, 2026
• Primary Completion (Estimated): December 12, 2026
• Study Completion (Estimated): February 10, 2027

Study Registration Dates

• First Submitted: January 17, 2026
• First Submitted That Met QC Criteria: May 16, 2026
• First Posted (Actual): May 20, 2026

Study Record Updates

• Last Update Posted (Actual): May 20, 2026
• Last Update Submitted That Met QC Criteria: May 16, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Eye Diseases; Corneal Diseases; Keratoconus
• Other Study ID Numbers: 36264PR131099/12/25

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: The statistical analysis results will be shared through the manuscript

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No