Isoinertial Training in Patients With COPD (ISTrainingCOPD)

Effect of Isoinertial Training on Muscle Strength and Functional Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Randomized Controlled Clinical Trial

Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.

Study Overview

• Status: Recruiting
• Conditions: COPD (Chronic Obstructive Pulmonary Disease)
• Intervention / Treatment: Device: Isoinertial training; Other: Traditional rehabilitation (control group)

Detailed Description

To assess the effects of an isoinertial training programme on muscle strength and functional capacity in older people diagnosed with chronic obstructive pulmonary disease (COPD), in a randomized controlled clinical trial. Thirty participants diagnosed with moderate to severe COPD, over 50 years (50% men, 50% women), will be included to analyze possible differences in the training response compared to the control group. Participants will sign the informed consent and randomly assign to the intervention or control group. The intervention consists in a supervised isoinertial training program, while the control group will continue with the usual pulmonary rehabilitation program. Patients will be subjected to an initial assessment that include the application of tests of functional capacity, muscle strength, as well as clinical parameters and sociodemographic characteristics. The intervention will last 8 weeks, with a frequency of 2 to 3 sessions per week. The training program will include exercises aimed at strengthening the upper and lower limbs, using a isoinertial device with controlled load progression.

• Study Type: Interventional
• Enrollment (Estimated): 30
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: David Murcia-Lesmes, PhD; Phone Number: +571 5460600; Email: david.murcia@docentes.umb.edu.co

Study Locations

• Colombia
  • Bogotá, DC
    • Bogotá, Bogotá, DC, Colombia, 110231
      • Recruiting
      • Universidad Manuela Beltrán
      • Principal Investigator: David Murcia-Lesmes, PhD
      • Sub-Investigator: Edwin Fernando Gutiérrez-Reyes, MSc
  • Ibagué
    • Ibague, Ibagué, Colombia, 730006
      • Recruiting
      • Pulsar Unidad de Neumologia y Rehabilitación Pulmonar

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• People between 50 - 80 years of age diagnosed with moderate or severe COPD
• No acute exacerbations in the last 4 weeks
• Sufficient functional capacity to exercise
• Signed informed consent

Exclusion Criteria:

• Presence of neurological, musculoskeletal, or cardiovascular diseases that significantly limit exercise performance or compromise participant safety; including uncontrolled hypertension, recent myocardial infarction, unstable angina, severe osteoarthritis, stroke sequelae, or Parkinson's disease.
• Contraindications to exercise participation according to medical evaluation.
• Recent surgeries in the past 3 months
• Simultaneous participation in other exercise programs
• Cognitive disorders

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Supervised isoinertial training; Participants will perform a supervised isoinertial training program during 8 weeks of follow-up	Device: Isoinertial training; Supervised isoinertial training: Participants will perform a supervised isoinertial training program during 8 weeks of follow-up; The intervention will have a frequency of 2 to 3 weekly sessions; The program will include exercises aimed at strengthening the upper and lower limbs using a isoinertial device; The training load will be progressive to each participant and adjusted according to the individual response.; The program will be carried out in combination with usual pulmonary rehabilitation care.
Active Comparator: Traditional rehabilitation; Participants involved in the usual pulmonary rehabilitation program; The usual recommendations for physical activity and clinical follow-up will be maintained; No isoinertial training	Other: Traditional rehabilitation (control group); Traditional treatment (control group); Participants involved in the usual pulmonary rehabilitation program during 8 weeks with a frequency of 2-3 sessions per week.; This program includes low- to moderate-intensity aerobic exercise, joint mobility activities and general strengthening exercises using conventional resources according to the clinic's rehabilitation protocol.; No isoinertial training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in upper limb muscle strength using the Hand Grip Test (HGT)	Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD.	Baseline and 8-week follow-up
Change in functional capacity by 6-minute walk test (6MWT)	The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity.	Baseline and 8-week follow-up
Lower limb functional performance	The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs	Baseline and 8-week follow-up
Change in functional mobility using the Timed Up and Go Test (TUG)	The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk.	Baseline and 8-week follow-up
Change in muscle quality index (MQI)	Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions	Baseline and 8-week follow-up

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in functional performance using 5 Times Sit-to-Stand Test (5STS)	Time required to perform 5 repetitions of standing and sitting will be measured, as a complementary indicator of lower limb function	Baseline and 8-week follow-up
Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ)	The SGRQ will be applied to assess the symptoms, activity and impact of the respiratory disease. This score ranges from 0 to 100 points, a higher score indicates poor health.	Baseline and 8-week follow-up
Changes in Body Mass Index (BMI)	Body mass index (BMI) will be assessed to characterize participants' anthropometric status. BMI will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m^2).	Baseline and 8-week follow-up
Changes in heart rate	Heart rate (bpm) will be measured using an automatic monitor	Baseline and 8-week follow-up
Changes in blood pressure	Diastolic and systolic blood pressure (mmHg) will be measured using a blood pressure monitor	Baseline and 8-week follow-up
Changes in oxygen saturation (SpO2)	Oxygen saturation (Percentage, %) will be measured using an oximeter.	Baseline and 8 week follow-up

Collaborators and Investigators

• Sponsor: Universidad Manuela Beltrán

Study record dates

Study Major Dates

• Study Start (Estimated): May 7, 2026
• Primary Completion (Estimated): July 25, 2026
• Study Completion (Estimated): July 27, 2026

Study Registration Dates

• First Submitted: May 5, 2026
• First Submitted That Met QC Criteria: May 19, 2026
• First Posted (Actual): May 22, 2026

Study Record Updates

• Last Update Posted (Actual): May 29, 2026
• Last Update Submitted That Met QC Criteria: May 26, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Exercise; Adults; Pulmonary Rehabilitation; Muscle Strength; Lung Disease; Functional Capacity; Interventional study; Flywheel training
• Additional Relevant MeSH Terms: Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases, Obstructive; Pathological Conditions, Signs and Symptoms; Behavior; Lung Diseases; Pulmonary Disease, Chronic Obstructive; Motor Activity; Investigative Techniques; Epidemiologic Research Design; Epidemiologic Methods; Research Design; Methods; Control Groups
• Other Study ID Numbers: DCTAFD24 23

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Data availability to external researchers is restricted to related project proposals upon request to the PI.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No