The Treatment Outcomes of Cesarean Scar Pregnancy

The Treatment Outcomes of Cesarean Scar Pregnancy：A Multicenter Prospective Randomized Controlled Study

A prospective randomized controlled study evaluating the impact of various treatment modalities for cesarean scar pregnancy on treatment outcomes and pregnancy outcomes

Study Overview

• Status: Recruiting
• Conditions: Cesarean Scar Pregnancy
• Intervention / Treatment: Other: different surgical treatment

Detailed Description

The excisional surgeries were conducted via excision of the cesarean scar pregnancy and closure of the uterine incision through a transvaginal approach or hysteroscopy-assisted laparoscopic approach.

Conservative surgeries refer to the removal of intrauterine pregnancy tissues through ultrasound-guided vacuum aspiration or hysteroscopic surgery.

• Study Type: Interventional
• Enrollment (Estimated): 82
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: xiuxiu jiang, ph.D; Phone Number: 0086-571-87061501; Email: jaingxiuxiu0418@zju.edu.cn

Study Locations

• China
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310006
      • Recruiting
      • Women's Hospital School of Medicine Zhejiang University
      • Contact: Xiuxiu Jiang, Ph.D; Phone Number: +8613588709941; Email: jiangxiuxiu0418@zju.edu.cn
      • Sub-Investigator: Wanren Zheng, MD
      • Sub-Investigator: Juan Yu, MD
      • Sub-Investigator: Meijun Guo, MD
      • Sub-Investigator: Ning Wang, MD
      • Sub-Investigator: Shanshan Ni, MD
      • Sub-Investigator: Xingmiao Li, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Women over 18 years old with a history of cesarean section
2. Ultrasound diagnosis of cesarean scar pregnancy
3. No severe internal or external diseases, such as liver disease, kidney disease, cardiovascular disease, cerebrovascular disease, etc., and able to tolerate surgery

Exclusion Criteria:

1. Women under the age of 18
2. CSP patients who have received treatment in other hospitals

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: excisional surgery group; The excisional surgeries were conducted via excision of the cesarean scar pregnancy and closure of the uterine incision through a transvaginal approach or hysteroscopy-assisted laparoscopic approach.	Other: different surgical treatment; The excisional surgeries were conducted via excision of the cesarean scar pregnancy and closure of the uterine incision through a transvaginal approach or hysteroscopy-assisted laparoscopic approach. Conservative surgeries refer to the removal of intrauterine pregnancy tissues through ultrasound-guided vacuum aspiration or hysteroscopic surgery.
Experimental: conservative surgery group; Conservative surgeries refer to the removal of intrauterine pregnancy tissues through ultrasound-guided vacuum aspiration or hysteroscopic surgery.	Other: different surgical treatment; The excisional surgeries were conducted via excision of the cesarean scar pregnancy and closure of the uterine incision through a transvaginal approach or hysteroscopy-assisted laparoscopic approach. Conservative surgeries refer to the removal of intrauterine pregnancy tissues through ultrasound-guided vacuum aspiration or hysteroscopic surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
successful surgical treatment	successful treatment rate after surgery	One day after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
complication	severe complication rate after surgery	One day after surgery

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
subsequent pregnancy rate	subsequent pregnancy rate after surgery	Up to 24 months after surgery without contraception and the time since the last menstrual period is 4 weeks or more.
CSP recurrence rate	CSP recurrence rate after surgery	Up to 24 months after surgery without contraception
pregnancy interval	pregnancy interval after surgery	Up to 24 months (the time interval between the cessation of contraception after surgery and the time of last menstrual period of the subsequent pregnancy)

Collaborators and Investigators

• Sponsor: Women's Hospital School Of Medicine Zhejiang University
• Investigators: Principal Investigator: xiuxiu jiang, women's hospital school of medicine Zhejiang uni

Study record dates

Study Major Dates

• Study Start (Actual): August 13, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026

Study Registration Dates

• First Submitted: August 12, 2025
• First Submitted That Met QC Criteria: May 26, 2026
• First Posted (Actual): May 27, 2026

Study Record Updates

• Last Update Posted (Actual): May 27, 2026
• Last Update Submitted That Met QC Criteria: May 26, 2026
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: XiuxiuJiang

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No