The Role of Resilience for Physical Functioning of Patients With Fibromyalgia Syndrome Using the 6-Min Walk Test (6MWT)

Fibromyalgia (FM) is a prevalent chronic pain disorder, characterized by widespread musculoskeletal pain and fatigue that is associated with significant functional limitations. Its mechanisms are only partially understood. The investigators hypothesize that physical functioning (as measured by the 6-Min Walk Test) of FM patients and healthy controls is negatively influenced by resilience and pain sensitivity. The investigators will perform a case control study to test our hypothesis within and between groups.

Study Overview

• Status: Not yet recruiting
• Conditions: Fibromyalgia; Physical Function; Six-minute Walk Test

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: Melyssa Godfrey, BS; Phone Number: 352-265-8901; Email: melyssa.m.g@ufl.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

This is a case-control study of FM and healthy controls (HC) that will be enrolled in a ratio of 1:1. Healthy controls will be age/gender matched to the FM group.

Description

Inclusion Criteria:

• Ages 18-70
• Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
• Healthy volunteers: No significant pain

Exclusion Criteria:

• Uncontrolled diabetes
• Cancer
• Uncontrolled coronary syndromes
• Peripheral neuropathies
• Unwillingness/inability to discontinue analgesics, hypnotics, anxiolytics, or stimulants

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Fibromyalgia; Participants who fulfill the 1990 and 2011 American College of Rheumatology Criteria for FM.
Healthy Volunteers; Age/gender matched volunteers who do not have significant pain.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Resilience score	The Brief Resilience Scale (BRS) is a self-report measure designed to assess an individual's ability to bounce back or recover from stress, adversity, and challenging life circumstances (Smith et al., 2008) scored ranging 6-30.	Through study completion (one visit - approx. 2 hours)
Performance in 6MWT	The total walking distance in the 6MWT is a measurement of how far an individual is able to walk (measured in meters, using a marked 30m hallway) within a 6 minute time period after being instructed to walk as far possible.	Through study completion (one visit - approx. 2 hours)

Collaborators and Investigators

• Sponsor: University of Florida
• Investigators: Principal Investigator: Roland Staud, MD, University of Florida

Study record dates

Study Major Dates

• Study Start (Estimated): April 30, 2026
• Primary Completion (Estimated): April 30, 2030
• Study Completion (Estimated): April 30, 2031

Study Registration Dates

• First Submitted: April 30, 2026
• First Submitted That Met QC Criteria: May 22, 2026
• First Posted (Actual): May 28, 2026

Study Record Updates

• Last Update Posted (Actual): May 28, 2026
• Last Update Submitted That Met QC Criteria: May 22, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Nervous System Diseases; Muscular Diseases; Neuromuscular Diseases; Rheumatic Diseases; Fibromyalgia
• Other Study ID Numbers: IRB202600417

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No