Comparison of First and Second Capillary Blood Drops for Blood Glucose Measurement

May 31, 2026 updated by: Ayten Kaya, Ordu University

Comparison of Capillary Blood Sampling Techniques for Blood Glucose Measurement in People With Diabetes: An Experimental Study

This study aimed to evaluate the effects of different capillary blood sampling techniques on blood glucose measurement results in people with diabetes. Blood glucose measurements obtained from the first and second capillary blood drops after antiseptic application were compared. In addition, measurements obtained with and without finger squeezing were evaluated. The findings may contribute to improving standardization in capillary blood glucose monitoring procedures and reducing unnecessary repeated finger punctures in clinical practice.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This methodological and experimental study evaluated whether different capillary blood sampling techniques influence blood glucose measurement results in people with diabetes. The study compared glucose measurements obtained from the first and second capillary blood drops and also evaluated measurements performed with and without finger squeezing under standardized clinical conditions. The findings are expected to contribute to the standardization of capillary blood glucose monitoring procedures and improve clinical practice by reducing unnecessary repeated finger punctures and enhancing participant comfort.

Study Type

Observational

Enrollment (Actual)

64

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adults with diabetes who were hospitalized in the internal medicine clinics of a state hospital during the study period and met the study inclusion criteria.

Description

Inclusion Criteria:

  • Aged 18 years or older
  • Diagnosed with diabetes mellitus
  • Provided written and verbal informed consent to participate in the study
  • Eligible for blood glucose measurement after at least 6 hours of fasting
  • No condition preventing capillary blood sampling from the fingertip
  • Physically and mentally able to undergo the measurement procedures specified in the study

Exclusion Criteria:

  • Presence of a physical disability or deformity affecting fingertip blood glucose measurement
  • Presence of coagulation disorders (e.g., hemophilia) or severe medical conditions affecting blood sampling
  • Use of steroids within the previous 24 hours that could affect blood glucose levels
  • Presence of physical or mental conditions limiting compliance with study procedures
  • Inability or unwillingness to provide informed consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Difference between blood glucose measurements obtained with and without finger squeezing
Time Frame: Day 1
Comparison of blood glucose values obtained from capillary blood samples collected with and without finger squeezing. Blood glucose measurements were obtained consecutively during a single study visit (Day 1), first from a capillary blood sample collected without finger squeezing and subsequently from a capillary blood sample collected with finger squeezing during the same blood sampling and measurement session
Day 1
Difference between blood glucose values obtained from the first and second capillary blood drops following antiseptic application
Time Frame: Day 1
Comparison of blood glucose values obtained from the first and second capillary blood drops after antiseptic application. The first and second blood drop measurements were obtained consecutively during the same capillary blood sampling and measurement session.
Day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ordu University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2025

Primary Completion (Actual)

July 30, 2025

Study Completion (Actual)

December 30, 2025

Study Registration Dates

First Submitted

May 19, 2026

First Submitted That Met QC Criteria

May 31, 2026

First Posted (Actual)

June 3, 2026

Study Record Updates

Last Update Posted (Actual)

June 3, 2026

Last Update Submitted That Met QC Criteria

May 31, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2024/212-BAEK239

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be publicly available due to confidentiality and privacy considerations. However, statistical data may be provided by the corresponding author upon reasonable request.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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