Interaction Between Head/Neck Position and C-MAC Blade Geometry on Videolaryngoscopic Intubation in Morbidly Obese Patients: A Randomized Controlled Trial (C-MAC)

June 4, 2026 updated by: Ain Shams University

This study aims to explore the effect of head/neck position (sniffing vs ramped) and C-MAC blade geometry (MAC vs D-blade) on intubation in morbidly obese patients.

The patients will be randomized into 4 groups:

  1. S MAC: Sniffing + MAC blade.
  2. R MAC: Ramped + MAC blade.
  3. S D-blade: Sniffing + D-blade.
  4. R D-blade: Ramped + D-blade.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

140

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Egypt
      • Cairo, Egypt, Egypt, 00202
        • AIN shams university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age 18-70 years.
  • BMI ≥ 40 kg/m².
  • ASA physical status III - IV.
  • Elective surgery requiring intubation.
  • Informed consent obtained.

Exclusion Criteria:

  • Anticipated difficult airway unrelated to obesity.
  • Cervical spine pathology.
  • Pregnancy.
  • Emergency surgery.
  • High aspiration risk.
  • OSA requiring CPAP >15 cmH₂O.
  • Need for awake intubation.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: S MAC: Sniffing + MAC blade.
the patient will be positioned in sniffing position and MAC blade will be used in intubation
Device: Sniffing position and using MAC blade.
Machintosch blade will be used in intubating patient in sniffing position
Active Comparator: Ramped position and using MAC blade.
the patient will be positioned in Ramped position and MAC blade will be used in intubation
Device: Ramped position and MAC Blade
MAC blade will be used in intubating patient in ramped postion
Active Comparator: S D-blade: Sniffing + D-blade.
the patient will be positioned in sniffing position and D-blade will be used in intubation
Device: videolaryngoscopy
D-blade will be used in intubating patient in sniffing position
Active Comparator: R D-blade: Ramped + D-blade.
the patient will be positioned in Ramped position and D-blade willbe used in intubation
Device: videolaryngosopy
D-blade will be used in intubating patient in Ramped position

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
Time Frame: seconds
Intubation time (seconds), from blade insertion to confirmed placement via capnography.
seconds

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ain Shams University

Investigators

  • Principal Investigator: fagr fathy abdo, Medical Doctorate, AIN shams university

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 17, 2026

Primary Completion (Estimated)

September 20, 2026

Study Completion (Estimated)

November 1, 2026

Study Registration Dates

First Submitted

June 4, 2026

First Submitted That Met QC Criteria

June 4, 2026

First Posted (Actual)

June 9, 2026

Study Record Updates

Last Update Posted (Actual)

June 9, 2026

Last Update Submitted That Met QC Criteria

June 4, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FMASU R81/2026

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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