Comparative Efficacy of Neuromobilization, Tendon Gliding Exercises, and Combined Techniques in Mild to Moderate Carpal Tunnel Syndrome

June 16, 2026 updated by: Ibadat International University, Islamabad

Comparative Efficacy of Neuromobilization Techniques, Tendon Gliding Exercises, and Combined Techniques in the Management of Mild to Moderate Carpal Tunnel Syndrome: A Randomized Controlled Trial

focuses on the comparative efficacy of Neuromobilization techniques, tendon gliding exercises, and their combined application in the management of mild to moderate Carpal Tunnel Syndrome through a randomized controlled trial (RCT)

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Aims to provide valuable evidence regarding the comparative and combined effects of Neuromobilization and tendon gliding exercises in managing mild to moderate Carpal Tunnel Syndrome. The findings may help physiotherapists develop optimized treatment strategies for improving pain, hand function, and quality of life among CTS patients.

Study Type

Interventional

Enrollment (Estimated)

52

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Pakistan
    • ICT
      • Islamabad, ICT, Pakistan
        • Recruiting
        • Dr. Akbar Niazi teaching Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • • Symptoms of CTS (pain, paresthesia in the area of hand innervated by the median nerve)

    • First and Second Trimester Pregnant women.
    • Mild to Moderate CTS patients.
    • Individuals experiencing wrist pain for a duration of at least 6-8 weeks without a history of trauma or specific diagnosis (e.g., fracture, arthritis).
    • Pain rated between 3 and 5 on (NPRS).
    • Present neurological disorders (e.g., carpal tunnel syndrome, cervical radiculopathy).
    • No prior physical therapy treatment for wrist pain in the last 3-6 months

Exclusion Criteria:

  • • History of traumatic injury, fracture, or surgery to the wrist or hand.

    • Diagnosis of systemic diseases affecting the wrist (e.g., rheumatoid arthritis, gout, or diabetes-related neuropathy).
    • Any skin condition or infection around the wrist that would contraindicate physical therapy.
    • Third Trimester Pregnant women
    • Individuals with serious cardiovascular or metabolic disorders.
    • patients currently undergoing other treatments specifically targeting CTS (e.g., steroid injections)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Combined Intervention Group
Participants in this group will receive a combination of Neuromobilization techniques and tendon gliding exercises
Other: Combined Intervention Group
will receive a combination of Neuromobilization techniques and tendon gliding exercises
Active Comparator: Neuromobilization Group
Participants in these groups will receive Neuromobilization techniques targeting the median nerve.
Other: Neuromobilization Group
will receive Neuromobilization techniques targeting the median nerve.
Active Comparator: Tendon Gliding Exercise Group
will receive tendon Gliding exercises targeting the median nerve
Other: Tendon Gliding Exercise Group
will receive tendon Gliding exercises targeting the median nerve

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain Intensity
Time Frame: baseline, 3rd week, and 8th week.
Measured using the Numeric Pain Rating Scale
baseline, 3rd week, and 8th week.
Functional Status and Symptom Severity
Time Frame: baseline, 3rd week, and 8th week
Measured using the Boston Carpal Tunnel Questionnaire
baseline, 3rd week, and 8th week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ibadat International University, Islamabad

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 3, 2026

Primary Completion (Estimated)

September 3, 2026

Study Completion (Estimated)

September 10, 2026

Study Registration Dates

First Submitted

June 2, 2026

First Submitted That Met QC Criteria

June 16, 2026

First Posted (Actual)

June 17, 2026

Study Record Updates

Last Update Posted (Actual)

June 17, 2026

Last Update Submitted That Met QC Criteria

June 16, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IIUI/RERC/ADT/2026/01/221

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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