Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold

June 25, 2026 updated by: Nora Abdelgawad Mohamed, Al-Azhar University

Clinical and Radiographic Evaluation of Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold : A Randomized Controlled Clinical Study

aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

22

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt
        • Alazhar university , cairo, egypt

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • 1. Partially edentulous patients with a maxillary posterior edentulous ridge for more than 4 months after extraction.

    2. Both males and females. 3. Adults aged between 18-50 years. 4. Systemically healthy individuals.

    5. Residual alveolar ridge height ranging from 4 to 6 mm (measured by preoperative CBCT) 6. No previous surgical or radiation treatment involving the maxillary sinus.

Exclusion Criteria:

-

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Sham Comparator: control
closed sinus lifting using xenograft alone, followed by implant placement.
Procedure: sinus lifting
closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.
Experimental: test group
closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.
Procedure: sinus lifting
closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
1. Bone height ( Apical Bone Height Gain ): Measured from first implant thread to sinus floor.
Time Frame: 6 months
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Al-Azhar University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 5, 2025

Primary Completion (Estimated)

November 10, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

June 25, 2026

First Submitted That Met QC Criteria

June 25, 2026

First Posted (Actual)

July 1, 2026

Study Record Updates

Last Update Posted (Actual)

July 1, 2026

Last Update Submitted That Met QC Criteria

June 25, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • P-ME-25-11

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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