Evaluation of Wear Resistance of CAD/CAM Hybrid Ceramic and Nano-Hybrid Composite Overlays in Endodontically Treated Molars and Their Effect on Natural Antagonist Teeth

Evaluation of Wear Resistance of CAD/CAM Hybrid Ceramic and Nano-Hybrid Composite Overlays in Endodontically Treated Molars and Their Effect on Natural Antagonist Teeth: A 24-Month Randomized Clinical Trial

This randomized clinical trial aims to to evaluate and compare the 24-month surface wear of the restoration and the surface wear of the opposing natural tooth structure of CAD/CAM Hybrid Ceramic (SHOFU Hard blocks) versus Resin-based Composite (BRILLIANT Crios) overlays, utilizing a digital subtraction methodology (Intraoral Scanner and Geometrical Subtraction Software) in endodontically treated molar teeth.

Study Overview

• Status: Not yet recruiting
• Conditions: Wear, Occlusal
• Intervention / Treatment: Procedure: SHOFU Hard blocks; Procedure: BRILLIANT Crios

Detailed Description

The rationale for this 24-month RCT is driven by the need for high-level, evidence-based data to guide clinical material selection for compromised teeth. This trial is designed to directly compare two materials specifically engineered to be stress-absorbing in the oral environment. The primary intervention, the SHOFU Restorative System (Hard blocks), is a Hybrid Ceramic engineered to combine the durability of ceramics with the elasticity of polymers. Its reduced hardness and dentin-like modulus allow for rapid machining and are associated with reduced antagonist abrasion compared to conventional ceramics. The second material, serving as the comparator, is the Coltène Restorative System (BRILLIANT Crios), which is a reinforced nano-hybrid composite characterized by an elastic modulus comparable to dentin, designed for optimal shock absorption and confirmed to be gentle on antagonist teeth.

Focusing the study on endodontically treated molars addresses a highly prevalent clinical scenario where maximizing the longevity of the restoration and the remaining tooth structure is paramount. The use of a full-cusp-coverage overlay design represents the maximum conservation approach for these compromised teeth while ensuring that the selected restorative materials do not exert harmful effects on opposing dentition.

• Study Type: Interventional
• Enrollment (Estimated): 24
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age between 22 and 45 years.
• Low to moderate caries risk.
• Normal occlusion.
• Absence of signs or symptoms of temporomandibular joint (TMJ) disorders.
• Satisfactory oral hygiene.
• Medically fit to receive routine restorative dental treatment.
• Permanent molars.
• Asymptomatic endodontically treated teeth.
• Homogeneous root canal fillings extending 1-2 mm from the radiographic apex.
• Compound cavities.
• Favorable occlusion.
• Presence of both an adjacent tooth and a sound opposing tooth in occlusion

Exclusion Criteria:

• * Presence of bruxism.

  • Poor patient cooperation.
  • Inability or unwillingness to attend follow-up appointments.
  • Anticipated travel during the study period.
  • Poor oral hygiene.
  • Chronic or advanced periodontitis.
  • Known allergies to any of the materials used in the study.
  • Patients who are pregnant or breastfeeding.
  • Teeth with <1" mm" of residual wall thickness.
  • Deep subgingival cavity margins.
  • Severe periodontal problems.
  • Radiographic signs of apical pathology.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: SHOFU Hard blocks; CAD/CAM Hybrid Ceramic, Overlay restored using the SHOFU cementation system.	Procedure: SHOFU Hard blocks; CAD/CAM Hybrid Ceramic, Overlay restored using the SHOFU cementation system.
Active Comparator: BRILLIANT Crios; Resin-based Composite, Overlay restored using the Coltène cementation system.	Procedure: BRILLIANT Crios; Resin-based Composite, Overlay restored using the Coltène cementation system.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Annual wear rate	Digital Scanner +Geometrical Subtraction Software	24 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Functional properties, Biological properties and Esthetic properties	FDI Criteria	24 months

Collaborators and Investigators

• Sponsor: Cairo University

Study record dates

Study Major Dates

• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): July 1, 2028
• Study Completion (Estimated): July 1, 2028

Study Registration Dates

• First Submitted: June 30, 2026
• First Submitted That Met QC Criteria: June 30, 2026
• First Posted (Actual): July 7, 2026

Study Record Updates

• Last Update Posted (Actual): July 7, 2026
• Last Update Submitted That Met QC Criteria: June 30, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Stomatognathic Diseases; Tooth Diseases; Tooth Wear; Tooth Attrition
• Other Study ID Numbers: 261292

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No