Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain

This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. This study will Compare pain intensity between intervention groups and assess functional disability outcomes. Furthermore, this will evaluate changes in quality of life and to analyze pain-related beliefs following PNE.

Study Overview

• Status: Not yet recruiting
• Conditions: Diabetic Neuropathic Pain
• Intervention / Treatment: Other: Pain Neurosciences Education + Neural Mobilization

• Study Type: Interventional
• Enrollment (Estimated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Roshan Farman, MSPT; Phone Number: +923188108470; Email: 5012324032@student.iiui.edu.pk
• Study Contact Backup: Name: Somiya Naz, PhD scholar; Phone Number: +923315163093; Email: somiyanaz@uipt.iiui.edu.pk

Study Locations

• Pakistan
  • Punjab Province
    • Rawalpindi, Punjab Province, Pakistan, 46000
      • Positive Solution Clinic, Wah Cantt
      • Contact: Mahjabeen Farooqui, MSPT; Phone Number: 3313666898; Email: mahafarooqui0@gmail.com
      • Contact: Somiya Asif, MSPT; Phone Number: 3435322291; Email: sumaiya.asif92@gmail.com
      • Principal Investigator: Roshan Farman, MSPT

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions

Exclusion Criteria:

Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Group A - Pain Neurosciences Education combined with Neural Mobilization; Pain neuroscience education (PNE) will be delivered through structured educational sessions focusing on pain physiology, neural sensitization, and pain modulation. PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations. Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial & common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes	Other: Pain Neurosciences Education + Neural Mobilization; In Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial & common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations
Active Comparator: Group B - Neural Mobilization Alone; Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial & common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes	Other: Pain Neurosciences Education + Neural Mobilization; In Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial & common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain intensity	Pain intensity will be evaluated using Numeric Pain Rating Scale	Baseline to week 6
Functional disability	Functional disability will be evaluated using Urdu version of Lower Extremity Functional Scale (LEFS)	Baseline to week 6
Quality of life	Quality of life will be evaluated by World Health Organization Quality Of Life-BREF	Baseline to week 6
Central sensitization	Central sensitization will be evaluated using Central Sensitization Inventory	Baseline to week 6

Collaborators and Investigators

• Sponsor: Ibadat International University, Islamabad

Study record dates

Study Major Dates

• Study Start (Estimated): July 10, 2026
• Primary Completion (Estimated): January 10, 2027
• Study Completion (Estimated): January 20, 2027

Study Registration Dates

• First Submitted: July 6, 2026
• First Submitted That Met QC Criteria: July 6, 2026
• First Posted (Actual): July 10, 2026

Study Record Updates

• Last Update Posted (Actual): July 10, 2026
• Last Update Submitted That Met QC Criteria: July 6, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: IIUI/RERC/ADT/2026/05/265

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No