Adropin Levels in Periodontal Disease

July 6, 2026 updated by: Zeynep Pınar Yucel, Giresun University

Adropin Levels in GCF and Serum of Periodontitis Patients

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.

Study Type

Observational

Enrollment (Actual)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction.

Criteria for periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Description

Inclusion Criteria:

  • having at least 20 natural teeth, excluding third molars
  • having no systemic disease
  • non-smokers
  • Diagnosed with periodontally health and periodontitis patients

Exclusion Criteria:

  • having any systemic diseases
  • smoking
  • current pregnancy or lactation
  • a history of periodontal treatment in the past 6 months
  • using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Group 1: Periodontally healthy individuals
Group 2: Periodontitis patients
Procedure: Nonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
1. Adropin levels
Time Frame: Baseline and at 6 weeks after therapy
Changes in Adropin levels before and after periodontal therapy
Baseline and at 6 weeks after therapy

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
TNF-alfa levels
Time Frame: baseline and at 6 weeks after therapy
Changes in TNF-alfa levels before and after periodontal therapy
baseline and at 6 weeks after therapy

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Giresun University

Collaborators

Aydin Adnan Menderes University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 2, 2018

Primary Completion (Actual)

September 2, 2020

Study Completion (Actual)

November 6, 2020

Study Registration Dates

First Submitted

July 6, 2026

First Submitted That Met QC Criteria

July 6, 2026

First Posted (Actual)

July 10, 2026

Study Record Updates

Last Update Posted (Actual)

July 10, 2026

Last Update Submitted That Met QC Criteria

July 6, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KAEK-37
  • SAĞ-BAP-A-150219-33 (Other Grant/Funding Number: Giresun University Scientific Research Projects Coordination Unit)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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