Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

March 12, 2019 updated by: Damascus University

Investigating the Role of ABO Blood Group in the Response to the Nonsurgical Periodontal Treatment.

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

To the best of our knowledge, this is the first (research) randomized clinical trial that assesses how patient respond to the nonsurgical periodontal treatment based on their blood group phenotype.

Study Type

Observational

Enrollment (Actual)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 60 years (ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients suffering from chronic periodontitis

Description

Inclusion Criteria:

  • systematically healthy.
  • have at least 20 teeth excluding the third molars.
  • had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study.
  • diagnosed with generalized chronic periodontitis (>30% of the sites have probing depth ≥4), and a minimum of six teeth with probing depth of 5-6 mm.

Exclusion Criteria:

  • smokers and alcoholics.
  • pregnancy.
  • history of a systematic disease such as diabetes, leukemia, epilepsy.
  • participants who are unable to perform routine oral hygiene.
  • use of orthodontic appliances.
  • participants who are unable to perform routine oral hygiene.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients whose blood type is A
Applying nonsurgical periodontal treatment (scaling and root planning).
Procedure: nonsurgical periodontal treatment
patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.
Other Names:
  • Conventional periodontal treatment
  • scalling and root planing
Patients whose blood type is B
Applying nonsurgical periodontal treatment (scaling and root planning).
Procedure: nonsurgical periodontal treatment
patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.
Other Names:
  • Conventional periodontal treatment
  • scalling and root planing
Patients whose blood type is AB
Applying nonsurgical periodontal treatment (scaling and root planning).
Procedure: nonsurgical periodontal treatment
patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.
Other Names:
  • Conventional periodontal treatment
  • scalling and root planing
Patients whose blood type is O
Applying nonsurgical periodontal treatment (scaling and root planning).
Procedure: nonsurgical periodontal treatment
patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.
Other Names:
  • Conventional periodontal treatment
  • scalling and root planing

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in relative attachment level.
Time Frame: measures will be taken at baseline and after two months from treatment.
the relative attachment level measures the length form the base of the periodontal pocket to a stent
measures will be taken at baseline and after two months from treatment.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in periodontal probing depth.
Time Frame: measures will be taken at baseline and after two months from treatment.
the distance between the gingival margin to the base of the periodontal pocket.
measures will be taken at baseline and after two months from treatment.
Change in gingival index
Time Frame: index will be taken at baseline and after two months from treatment.
it is used to designate the level of the gingival inflammation.
index will be taken at baseline and after two months from treatment.
Change in plaque Index
Time Frame: index will be taken at baseline and after two months from treatment.
it is used to designate the level of plaque accumulation.
index will be taken at baseline and after two months from treatment.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Damascus University

Investigators

  • Principal Investigator: Mohammad Ammar Kouky, DDS MSc, PhD Student in Periododontics, University of Damascus Dental School, Damascus
  • Study Chair: Mohammad Monzer Alsabbagh, DDS MSc PhD, Associate Professor of Periodontics, University of Damascus Dental School, Damascus, Syria

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

January 15, 2018

Primary Completion (ACTUAL)

October 1, 2018

Study Completion (ACTUAL)

March 10, 2019

Study Registration Dates

First Submitted

August 2, 2018

First Submitted That Met QC Criteria

August 22, 2018

First Posted (ACTUAL)

August 23, 2018

Study Record Updates

Last Update Posted (ACTUAL)

March 13, 2019

Last Update Submitted That Met QC Criteria

March 12, 2019

Last Verified

March 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UDDS-Perio-03-2018

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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