Understanding Vision Problems Linked to the Brain and Nerves in People Seen at Our Eye Clinic. (ESNOPED-UK)

Epidemiological Study of Neuro-ophthalmological Presentations in an Eye Department in the UK

The reason for the recognised lack of epidemiological data of all NO conditions presenting to eye departments is attributed to the fact that they often fall in the grey zones between neuro-ophthalmologists, neurosurgeons and neurologists.

. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns.

Study Overview

• Status: Not yet recruiting
• Conditions: Neuro-ophthalmological Conditions
• Intervention / Treatment: Other: No Intervention: Observational Cohort

Detailed Description

The current study proposes to collect prospective data on patients seen within an eye department in the UK. The findings of such a prospective study will help to improve understanding of the NO disease burden and temporal trends. It will also help to further identify the demographic and systemic associations of NO conditions. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns. This may help to design clinics with the view to incorporate identifiable multidisciplinary inputs from neurology, neuro-surgery, radiology and emergency services, who are the recognised key stakeholders for the management of NO conditions. Real-world data in such a cohort of NO conditions may also help to detect rare associations or novel disease presentations.

• Study Type: Observational
• Enrollment (Estimated): 840

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients seen at the Royal Wolverhampton NHS Trust's Eye Department who have a NO diagnosis and meet the eligibility criteria will be selected.

Description

Inclusion Criteria:

• 1. Participants aged ≥ 18 years. 2. Participants seen at the Royal Wolverhampton NHS Trust's Eye Department. 3. Participants with a diagnosis of NO.

Exclusion Criteria:

• 1. Participants aged < 18 years. 2. Participants who do not have a diagnosis of NO. 3. Participants who have opted out of their data being used for research (National Data Opt-out).

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Analysis of the incidence and patterns of presentation of common NO conditions compared to other published studies.	From enrollment to 12 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Concordance rates between initial and final diagnosis.	From enrollment to 12 months
Detailed analysis of rare presentations, with a view to share knowledge gained from this in educational meetings.	From enrollment to 12 months

Collaborators and Investigators

• Sponsor: The Royal Wolverhampton Hospitals NHS Trust

Study record dates

Study Major Dates

• Study Start (Estimated): January 1, 2027
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027

Study Registration Dates

• First Submitted: July 14, 2026
• First Submitted That Met QC Criteria: July 14, 2026
• First Posted (Actual): July 17, 2026

Study Record Updates

• Last Update Posted (Actual): July 17, 2026
• Last Update Submitted That Met QC Criteria: July 14, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 2026EYE149

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No