Effect of GMI With and Without NM on LE in Cancer Patients With CIPN (CIPN)

July 14, 2026 updated by: University of Faisalabad

Effect of Graded Motor Imagery With and Without Neural Mobilization on Lower Extremity in Cancer Patients With Chemotherapy-induced Peripheral Neuropathy

The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are:

- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

48

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Punjab Province
      • Faisalābad, Punjab Province, Pakistan, 38000
        • The university of Faisalabad

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Both male and female
  • Age ranging from 31 to 65 years
  • Diagnosed cancer patients (stage 1 to 3, cancer of any kind)
  • Chemotherapy sessions (antineoplastic drugs) - at least 1 session
  • Presence of glove and stocking peripheral neuropathy
  • LANSS score greater than 12
  • Agreed to give complete follow-up

Exclusion Criteria:

  • Any co-morbid conditions that can cause peripheral neuropathy e.g. diabetes, chronic kidney failure
  • Any trauma history that can cause peripheral neuropathic symptoms
  • Pre-existing nerve entrapment syndromes
  • Diagnosed stage 4 cancer patients
  • Cancer patients taking palliative chemotherapy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group A - Graded Motor Imagery
Graded motor imagery sessions were provided twice a week for six weeks. Each GMI phase lasted for two weeks.
Other: Graded Motor Imagery
Graded motor imagery is a series of three steps. The first step, lateral recognition, includes graded left and right judgment exercises. The second step involves imagining the performance of movements and the third, and last step involves performing movements in front of a mirror.
Active Comparator: Group B - Grade Motor Imagey with Neural Mobilization
Graded motor imagery with neural mobilization sessions were provided twice a week for six weeks.
Other: Graded Motor Imagery
Graded motor imagery is a series of three steps. The first step, lateral recognition, includes graded left and right judgment exercises. The second step involves imagining the performance of movements and the third, and last step involves performing movements in front of a mirror.
Other: Neural Mobilization
Nerve mobilization allows movement between structures of nervous system and its surrounding areas. It is used to mobilize the nervous system and maintain equilibrium inside the nervous system as well as in structures present in its surroundings.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
LANSS
Time Frame: Baseline, week 3 (mid-intervention), week 6 (post intervention)
Leeds Assessment of Neuropathic Symptoms and Sign
Baseline, week 3 (mid-intervention), week 6 (post intervention)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Romberg Test
Time Frame: Baseline, week 6 (post-intervention)
Quantitative version of Romberg Test
Baseline, week 6 (post-intervention)
EORTC-QLQ-CIPN20
Time Frame: Baseline, week 6 (post-intervention)
European Organization of Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy Induced Peripheral Neuropathy 20
Baseline, week 6 (post-intervention)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Faisalabad

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 1, 2025

Primary Completion (Actual)

June 6, 2025

Study Completion (Actual)

June 6, 2025

Study Registration Dates

First Submitted

July 14, 2026

First Submitted That Met QC Criteria

July 14, 2026

First Posted (Actual)

July 17, 2026

Study Record Updates

Last Update Posted (Actual)

July 17, 2026

Last Update Submitted That Met QC Criteria

July 14, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TUF/IRB/98/2025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Cancer

Clinical Trials on Graded Motor Imagery

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Armenia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe