AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration (RETION)

July 21, 2026 updated by: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

Primary objective:

- Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope.

Secondary objectives:

  • To measure the reproducibility of assessments;
  • To evaluate the detection of progressive changes.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Patients:

  • 100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.)
  • 100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.)
  • Male or female
  • Covered by health insurance

Healthy volunteers:

  • 30 subjects aged over 50 and under 80
  • 30 subjects aged over 18 and under 50
  • Male or female
  • Healthy subjects with no known condition that directly or indirectly affects the structure of the eye
  • Covered by health insurance

For all subjects:

  • Inability to remain motionless on a standard ophthalmic chin rest. RETION_Protocol_v2.0 dated June 10, 2026_IDRCB: 2026-A00324-47 Page 10 of 44
  • Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol;
  • Participants allergic to tropicamide in cases where pupil dilation is required.

Study Type

Interventional

Enrollment (Estimated)

260

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Patients:

  • 100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.)
  • 100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.)
  • Male or female
  • Covered by health insurance

Healthy volunteers:

  • 30 subjects aged over 50 and under 80
  • 30 subjects aged over 18 and under 50
  • Male or female
  • Healthy subjects with no known condition that directly or indirectly affects the structure of the eye
  • Covered by health insurance

Exclusion Criteria:

For all subjects:

  • Inability to remain motionless on a standard ophthalmic chin rest. RETION_Protocol_v2.0 dated June 10, 2026_IDRCB: 2026-A00324-47 Page 10 of 44
  • Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol;
  • Participants allergic to tropicamide in cases where pupil dilation is required. ☞ Wearing glasses or contact lenses to correct a refractive error is not considered an exclusion criterion.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: MONA imaging system
acquisition mode with MONA imaging system
Device: MONA Imaging System
acquisition mode with mona system

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Proportion of images obtained with the MONA system deemed usable for the analysis of retinal microstructures.
Time Frame: 48 months

Images are considered usable if they allow for:

  • visualization of retinal microstructures (yes/no);
  • measurement of cell density (yes/no);
  • measurement of vascular diameter (yes/no).
48 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

April 1, 2030

Study Registration Dates

First Submitted

July 21, 2026

First Submitted That Met QC Criteria

July 21, 2026

First Posted (Actual)

July 24, 2026

Study Record Updates

Last Update Posted (Actual)

July 24, 2026

Last Update Submitted That Met QC Criteria

July 21, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P26-01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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