Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation (SUGAR-LT)

August 24, 2026 updated by: Medical University of Warsaw

Intraoperative Glycemic Variability and the Risk of Infectious Complications After Elective Liver Transplantation: A Prospective Cohort Study

This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation. This is an observational study with no intervention beyond standard perioperative care. Glycemic and clinical outcome data will be obtained from routinely collected medical records of patients undergoing liver transplantation at the 2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw.

Study Overview

Status

Not yet recruiting

Conditions

Liver Transplantation (LT)

Study Type

Observational

Enrollment (Estimated)

240

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Paula Dudek, MD
Phone Number: +225992002
Email: paula.dudek@wum.edu.pl

Study Locations

Poland
- - Warsaw, Poland
    - Medical University of Warsaw
    - Contact:
      
      Paula Dudek, MD
      
      Phone Number: +225992002
      
      Email: paula.dudek@wum.edu.pl

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Sampling Method

Non-Probability Sample

Study Population

patients undergoing liver transplantation at the 2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw.

Description

Inclusion Criteria:

Age over 18 years
Elective orthotopic liver transplantation

Exclusion Criteria:

Liver retransplantation
multi-organ transplantation
Urgent/emergency transplantation
Active infection under antibiotic treatment at the time of surgery
Preoperative systemic inflammatory response syndrome (SIRS)
Incomplete intraoperative glycemic data
Pregnancy
Participation in another interventional study that could affect glycemic control or infection risk

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Occurrence of at least one infectious complication within 30 days after liver transplantation Time Frame: 30 days	Binary outcome (yes/no), including: pneumonia (clinical, radiological, and microbiological criteria), urinary tract infection (clinical symptoms + positive urine culture), surgical site infection per CDC criteria, sepsis/septic shock per Sepsis-3 criteria.	30 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Medical University of Warsaw

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 1, 2026

Primary Completion (Estimated)

July 30, 2027

Study Completion (Estimated)

July 30, 2027

Study Registration Dates

First Submitted

July 27, 2026

First Submitted That Met QC Criteria

August 24, 2026

First Posted (Actual)

August 26, 2026

Study Record Updates

Last Update Posted (Actual)