Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process

August 31, 2026 updated by: Mansoura University

Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process : Randomized Clinical Trial

This study assess the ability of Asiaticoside based Intracanal medication compared to the commonly used Intracanal medicament ( calcium hydroxide Ca(OH) 2) on the outcome of the revascularization process in immature teeth

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
      • Al Mansurah, Egypt
        • Recruiting
        • Mansoura University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Both gender
  • patients having permanent anterior teeth with necrotic pulp and immature apex
  • Good general health
  • pulp space not needed for post and core

Exclusion Criteria:

  • Radiographic identification of root fracture or abnormality
  • Uncooperative patients
  • Root resorption (internal or external)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Asiaticoside
Procedure: Intracanal medication
Intracanal Medication for 3 weeks in Revascularization Process
Experimental: Calcium hydroxide
Procedure: Intracanal medication
Intracanal Medication for 3 weeks in Revascularization Process

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Periapical Bone Formation
Time Frame: 12 months
Radiographic evidence of periapical bone formation
12 months
Increase In Root Length
Time Frame: 12 monthsl
Radiographic increase in root length ( Millimeters(mm))
12 monthsl
Increase In Dentinal Wall Thickness
Time Frame: 12 months
Radiographic increase in dentinal wall thickness measured using digital image analysis (Millimeters(mm))
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mansoura University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 15, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2028

Study Registration Dates

First Submitted

August 31, 2026

First Submitted That Met QC Criteria

August 31, 2026

First Posted (Actual)

September 3, 2026

Study Record Updates

Last Update Posted (Actual)

September 3, 2026

Last Update Submitted That Met QC Criteria

August 31, 2026

Last Verified

December 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • A01010024RC

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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