Effectiveness of Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges During Delayed Implant Placement (CBCT-GBR-SECTG)

October 1, 2026 updated by: Donia Ayman, Cairo University

Clinical Effectiveness of Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Simultaneous Hard and Soft Tissue Augmentation During Delayed Implant Placement in Horizontally Deficient Alveolar Ridges: An Interventional Case Series

This study evaluates the clinical effectiveness of using a patient's own subepithelial connective tissue graft as a natural barrier membrane during simultaneous hard and soft tissue augmentation in areas of the jawbone with insufficient horizontal width. The procedure will be performed during delayed dental implant placement. The study aims to assess changes in hard and soft tissue dimensions and the clinical outcomes of this approach in patients with horizontally deficient alveolar ridges.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

10

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion criteria:

  • Presence of a single missing tooth with both neighboring teeth present
  • Patients at least 18 years of age
  • Good oral hygiene defined as full-mouth plaque score ≤25% (O'Leary, Drake, & Naylor, 1972)
  • Seibert class I defect at the single tooth gap as clinically assessed with buccopalatal bone dimension of at least 4 mm.
  • Patients agreeing to follow up period and sign informed consent

Exclusion criteria:

  • Pathological lesions (abscess-cyst-acute infection) in the defect site
  • Systemic diseases that would interfere with bone metabolism
  • Uncontrolled diabetic patients
  • Ongoing treatment or a history of recent chemotherapy or radiotherapy
  • Poor oral hygiene after hygienic phase (Plaque control record over 30%) or Active periodontal disease
  • Smoking (more than 10 cigarettes)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation

patient received intrasulcular incision, intrasulcular incisions and vertical release incision, full-thickness flap elevation was performed, autogenous bone collection was done from implant site then the implant placed; SCTG was harvested and placed as an autogenous barrier membrane over double layer of bone graft autogenous then Xeno graft followed by suturing
Procedure: Subepithelial Connective Tissue Graft as an Autogenous Barrier Membrane for Hard and Soft Tissue Augmentation in Horizontally Deficient Ridges during delayed implant placement

after local anesthetic injection, patient received intrasulcular incision, intrasulcular incisions and vertical release incisions, full-thickness flap elevation was performed, autogenous bone collection was done from implant site then the implant placed; SCTG was harvested and placed as an autogenous barrier membrane over double layer of bone graft autogenous then Xeno graft followed by suturing

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Horizontal bone gain
Time Frame: Baseline and 6 months after implant placement

Change in horizontal alveolar bone width from baseline to 6 months after implant placement, measured in millimeters (mm) using standardized radiographic assessment.
Baseline and 6 months after implant placement

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
change in buccal and crestal soft tissue thickness
Time Frame: baseline and 6 months after implant placement

Change in buccal and crestal soft tissue thickness at the implant site from baseline to 6 months after implant placement, measured in millimeters (mm).
baseline and 6 months after implant placement

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

October 1, 2026

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

September 1, 2027

Study Registration Dates

First Submitted

October 1, 2026

First Submitted That Met QC Criteria

October 1, 2026

First Posted (Actual)

October 6, 2026

Study Record Updates

Last Update Posted (Actual)

October 6, 2026

Last Update Submitted That Met QC Criteria

October 1, 2026

Last Verified

October 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PER 6-3-2-001

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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