Clinical Trials on ALK-positive NSCLC

Total 436088 results

Cubist Pharmaceuticals LLC

Completed

Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics

Gram Positive Bacterial Infection

United States
Emory University

Terminated

Pioglitazone and Tyrosine Kinase Inhibitor in Treating Patients With Relapsed Chronic Myeloid Leukemia

Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States
AC Camargo Cancer Center
H. Lee Moffitt Cancer Center and Research Institute

Completed

Study of Tamoxifen in Well Differentiated Neuroendocrine Tumors and Hormone Receptor Positive Expression (HORMONET)

Neuroendocrine Tumors | Estrogen Receptor Positive Tumor | Progesterone Receptor Positive Tumor

United States, Brazil
Alliance Foundation Trials, LLC.
Pfizer; Syneos Health; UNICANCER; German Breast Group; SOLTI Breast Cancer Research... and other collaborators

Active, not recruiting

Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer (PATINA)

HER-2 Positive Breast Cancer | Estrogen Receptor Positive Breast Cancer

United States, Spain, France, Italy, Germany, Australia, Portugal, New Zealand
China Meitan General Hospital
Marino Biotechnology Co., Ltd.

Unknown

Anti-mesothelin CAR T Cells for Patients With Recurrent or Metastatic Malignant Tumors

Mesothelin Positive Tumors

China
Pfizer

Completed

Effect of Linezolid on Ex Vivo Neutrophil and Monocyte Function in Healthy Males

Gram Positive Infection

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Anhui Provincial Hospital

Not yet recruiting

UTAA09 Injection in the Treatment of Relapsed/Refractory Hematolymphatic Malignancies.

CD19-positive Relapsed or Refractory B-cell Malignancies

China
Cairo University

Not yet recruiting

THE EFFECT OF RADIOFREQUENCY ON POSTMENOPAUSAL ADIPOSE TISSUE

Show Positive Effect of Radiofrequancy on Postmenopausal Adipose Tissue
Women and Infants Hospital of Rhode Island

Completed

Intrapartum Vancomycin for Group B Streptococcus (GBS) Prophylaxis

GBS Positive | Women in Labor Given Vancomycin for Prophylaxis

United States
Eli Lilly and Company

Completed

A Study of Abemaciclib (LY2835219) in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer (monarcHER)

HER-2 Positive Breast Cancer | Hormone Receptor Positive Breast Cancer

Spain, United States, Korea, Republic of, Belgium, France, Germany, Italy, Australia, Argentina, Canada, United Kingdom, Mexico, Brazil, Greece
Sichuan University

Recruiting

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

NSCLC | PD-1 Inhibitor | Leptomeningeal Metastasis | Low Dose Radiotherapy

China
Alethia Biotherapeutics

Completed

AB-16B5 Combined With Docetaxel in Subjects With Metastatic Non-Small Cell Lung Cancer (EGIA-002)

NSCLC Stage IV

United States, Canada
Imperial College London
Hammersmith Hospitals NHS Trust

Completed

Oral Antibiotic Treatment at Home Instead of Intravenous Treatment in Hospital for Resistant Gram Positive Infections

Staphylococcal Infections | Gram-positive Bacterial Infections

United Kingdom
Eric Bernicker, MD
Millennium Pharmaceuticals, Inc.; The Methodist Hospital Research Institute

Withdrawn

Alsertib (MLN8237) and Brentuximab Vedotin for Relapsed/Refractory CD30-Positive Lymphomas and Solid Malignancies (AD3LE)

CD30-positive Lymphoma | CD30-positive Solid Tumor

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy

Primary Myelofibrosis | Thrombocytopenia | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States
Bristol-Myers Squibb

Recruiting

A Study of BMS-986315 and Nivolumab in Combination With Chemotherapy in Participants With First-line Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

NSCLC

United States, Argentina, Chile, France, Italy, Poland, Romania, Spain, Australia
Mirati Therapeutics Inc.

Recruiting

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation (202200050434)

Metastatic Lung Cancer | Advanced NSCLC

United States, Spain, Greece, Hungary, France, Italy, Poland
Instituto do Cancer do Estado de São Paulo

Completed

Cachexia in NSCLC Patients: Diagnosis, Characterization, Prognosis, Functional and Skeletal Muscle Implications (LUCAX01)

NSCLC Stage IV

Brazil
Spanish Breast Cancer Research Group
Seagen Inc.

Recruiting

Efficacy and Safety of the Combination of Trastuzumab Plus TUCAtinib Plus viNorelbine in Patients With HER2-positive Non-resectable Locally Advanced or Metastatic Breast Cancer (TrasTUCAN)

HER2-positive Metastatic Breast Cancer | Locally Advanced HER2 Positive Breast Carcinoma

Spain
Bavarian Nordic

Active, not recruiting

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

Chordoma | HER2-positive Breast Cancer | HER2-positive Gastric/Gastroesophageal Junction Cancer

United States
European Georges Pompidou Hospital
APHP

Recruiting

Pronostic and Predictive Value of EMT in Localized Lung Cancer (TWISTlung)

Progression | Surgery | NSCLC, Stage I, II, IIIA, IIIB | Epithelial Mesenchymal Transition

France
Peking University People's Hospital

Unknown

Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL, MEthylation Based Dynamic Analysis for Lung Cancer). (MEDAL)

Carcinoma | NSCLC | Lung Cancer | Lung Neoplasm

China
Ataturk University

Completed

White Noise in Nasal Cpap Application

Nasal Continuous Positive Airway Pressure

Turkey
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Radiation Therapy Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Breast Cancer

Invasive Breast Carcinoma | Estrogen Receptor Positive | HER2/Neu Negative | Progesterone Receptor Positive

United States
Jennifer Lee Caswell-Jin
National Cancer Institute (NCI); QED Therapeutics, Inc.

Terminated

Study of Infigratinib in Combination With Tamoxifen in Hormone Receptor Positive, HER2 Negative, FGFR Altered Advanced Breast Cancer

Breast Cancer | HER2-negative Breast Cancer | ER Positive Breast Cancer | PR-Positive Breast Cancer

United States
Shanghai Zhongshan Hospital
Fudan University; University Hospital, Basel, Switzerland; Zhongshan Hospital... and other collaborators

Recruiting

Individualized PEEP Titration on Postoperative Pulmonary Complications

Laparoscopic Surgery | Elderly | Postoperative Pulmonary Complications | Positive End-expiratory Pressure

China, Switzerland
Texas Tech University Health Sciences Center, El...

Withdrawn

AUY922 With Lapatinib and Letrozole for ER+ HER2+ Advanced Breast Cancer

Breast Cancer | Metastatic Breast Cancer | HER-2 Positive Breast Cancer | ER Positive Breast Cancer
Rambam Health Care Campus

Completed

Differential Lung Ventilation vs. CPAP

One Lung Ventilation | Continuous Positive Airway Pressure | Differential Lung Ventilation

Israel
Region Örebro County

Unknown

Airway Effects of PEEP During Anesthesia Induction.

Airway Management | Positive End Expiratory Pressure | Mask-ventilation | Anesthesia Induction
University Hospital, Essen

Completed

Exploring the Theragnostic Value of Osimertinib in EGFR-mutated Lung Cancer (THEROS)

NSCLC | EGFR T790M | FDG-PET

Germany
Zhejiang Cancer Hospital
Hangzhou Cancer Hospital

Unknown

Temozolomide and Concomitant Whole Brain Radiotherapy in NSCLC Patients With Brain Metastases

NSCLC
Merck Sharp & Dohme LLC

Completed

A Pharmacokinetic Study of Tedizolid Phosphate in Pediatric Participants With Gram-Positive Infections (MK-1986-014)

Gram-Positive Infections

United States, Bulgaria, Colombia, Norway, United Kingdom
Cancer Trials Ireland
University College Dublin; Technological University Dublin

Recruiting

'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung) (SOURCE Lung)

NSCLC/Oligometastatic Cancer (Single Lung Lesion)

Ireland
Hoffmann-La Roche

Completed

A Study To Monitor Lung Cancer Patients Activity And Assess Performance Status Through A Wearable Device. (Lupa-01)

Non-Small Cell Lung Cancer (NSCLC)

Spain
Fundacion Clinic per a la Recerca Biomédica

Completed

Open-label Study in Patients With Metastatic NSLC Treated With Cisplatin, Gemcitabine and Bevacizumab

Non-Small Cell Lung Cancer (NSCLC)

Spain
Jiangsu HengRui Medicine Co., Ltd.

Unknown

A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving Chemotherapy

NSCLC | Neutropenia | Febrile Neutropenia

China
QuantumLeap Healthcare Collaborative
Byondis B.V.

Withdrawn

ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer

Ovarian Cancer | Metastatic Cancer | Metastatic Breast Cancer | Bladder Cancer | Triple Negative Breast Cancer | HER2-positive Breast Cancer | Gastroesophageal Adenocarcinoma | Ovarian Carcinoma | HER2-positive Gastric Cancer | Metastatic Gastrointestinal Carcinoid Tumor | HER2-positive Metastatic Breast... and other conditions

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Merck Sharp & Dohme LLC

Completed

Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C)

MSI Positive Colorectal Cancer | MSI Negative Colorectal Cancer | MSI Positive Non-Colorectal Cancers

United States
Charite University, Berlin, Germany

Recruiting

Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS) (ART-02)

Head and Neck Cancer | Esophageal Cancer | NSCLC | Prostate Cancer | SCLC | Bladder Cancer | Cervix Cancer | Rectum Cancer | Other Carcinoma

Germany
Clovis Oncology, Inc.

Terminated

A Study to Assess the Safety and Efficacy of the VEGFR-FGFR-PDGFR Inhibitor, Lucitanib, Given to Patients With Metastatic Breast Cancer

Breast Cancer | Metastatic Breast Cancer | Estrogen Receptor Positive | Triple Negative | HER2 | HER2 Positive | MBC | ER

United States
Novartis Pharmaceuticals

Completed

A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors

ALK-positive Advanced Tumors

Italy, Spain, Denmark, United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic | Minimal Residual Disease | NSCLC Stage IV | Nsclc | Metastatic Non Small Cell Lung Cancer

United States
Jonsson Comprehensive Cancer Center
California Institute for Regenerative Medicine (CIRM)

Terminated

Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer (NYESO SCT)

Sarcoma | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | HLA-A*0201 Positive Cells Present | NY-ESO-1 Positive

United States
Adrienne G. Waks
Eli Lilly and Company; Verastem, Inc.

Recruiting

VS-6766+Abema+Fulv in Met HR+/HER- BC

Breast Cancer | Hormone Receptor-positive Breast Cancer | Hormone Receptor Positive HER-2 Negative Breast Cancer

United States
Shanghai Chest Hospital

Not yet recruiting

Almonertinib Versus Osimertinib in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases (ATTACK)

NSCLC
Samsung Medical Center
National Evidence-Based Healthcare Collaborating Agency

Recruiting

The Prospective Non-randomized Case-control Study From Real-world Lung Cancer Patients (OPTIMUS)

Non-small Cell Lung Cancer (NSCLC)

Korea, Republic of
St. Joseph's Healthcare Hamilton

Completed

AI-EBUS-Elastography for LN Staging (AI-EBUS-E)

NSCLC | Lung Cancer | Artificial Intelligence | Elastography | Endobronchial Ultrasound

Canada
Takeda

Withdrawn

A Real World Study of Mobocertinib in Adults With Lung Cancer in China (MEANING) (MEANING-20)

Non-small Cell Lung Cancer (NSCLC)

China
Stanford University

Completed

Individualized Lung Tumor Stereotactic Ablative Radiotherapy (iSABR)

Non-small Cell Lung Cancer (NSCLC)

United States, Japan, Canada
University of Louisville
James Graham Brown Cancer Center

Withdrawn

STEREOtactic Radiation and Chemotherapy in Lung Cancer (STEREO) (STEREO)

Non-small Cell Lung Cancer (NSCLC)

United States

Clinical Trials on ALK-positive NSCLC

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