Clinical Trials on Aplastic Anemia

Total 5311 results

Mitchell Cairo

Recruiting

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Hodgkin Lymphoma | Sickle Cell Disease | Acute Leukemia | Beta-Thalassemia | Non-hodgkin Lymphoma | Severe Aplastic Anemia | Diamond Blackfan Anemia | Amegakaryocytic Thrombocytopenia | Kostmann

United States
Peking Union Medical College Hospital

Recruiting

Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System

Aplastic Anemia | Drug Therapy | CSA

China
The Korean Society of Pediatric Hematology Oncology

Unknown

Flu+CPM+rATG Conditioning Regimes for Unrelated Bone Marrow Transplantation (UBMT)(or Mobilized Peripheral Blood)in Severe Aplastic Anemia (SAA)

Anemia, Aplastic

Korea, Republic of
The Korean Society of Pediatric Hematology Oncology

Unknown

Reduced Toxicity Fludarabine (Flu) + Cyclophosphamide (CPM) + Rabbit Antithymocyte Globulin (rATG) Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA)

Aplastic Anemia

Korea, Republic of
Burnasyan Federal Medical Biophysical Center

Unknown

Effectiveness and Safety of MMSCs for Enhancing Hematopoietic Recovery and Prophylaxis of Neutropenic Enterocolitis

Neutropenic Enterocolitis | Myeloablative Chemotherapy Induced Bone Marrow Aplasia

Russian Federation
Peking University People's Hospital

Unknown

Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

Aplastic Anemia | Stem Cell Transplant Complications | Engraft Failure

China
Cellphire Therapeutics, Inc.
Department of Health and Human Services

Completed

Thrombosomes® in Bleeding Thrombocytopenic Patients

Hematologic Diseases | Thrombocytopenia | Bone Marrow Aplasia

United States, Norway
Cooperative Study Group A for Hematology

Unknown

Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia (CyATG-FluATG)

Aplastic Anemia

Korea, Republic of
Novartis

Completed

Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload

Myelodysplastic Syndromes | Hemoglobinopathies | Diamond-Blackfan Anemia | Transfusional Iron Overload | Other Inherited or Acquired Anaemia | MPD Syndrome | Other Rare Anaemias

Australia
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

Bone Marrow Failure Syndromes | Severe Aplastic Anemia

United States
Northwell Health

Terminated

Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia (ACE-011-DBA)

Diamond Blackfan Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia

Diamond Blackfan Anemia

United States
Beth Israel Medical Center

Completed

Extended Platelet Parameters as a Means to Differentiate Immune Thrombocytopenia From Hypo-proliferative Thrombocytopenias.

Immune Thrombocytopenia | Myelodysplasia | Chemotherapy Induced Thrombocytopenia | Aplastic Anaemia

United States
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of Exjade in the Treatment of Transfusion-dependent Iron Overload in Aplastic Anemia Patients

Aplastic Anemia

Russian Federation
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia

Iron Overload

China
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia

Hepatitis-Associated Aplastic Anemia

United States
Federal Scientific Clinical Centre of Pediatric...

Unknown

L-leucine in Diamond Blackfan Anemia Patients

Diamond Blackfan Anemia

Russian Federation
Feinstein Institute for Medical Research
Diamond Blackfan Anemia Foundation, Inc.

Recruiting

Diamond Blackfan Anemia Registry (DBAR) (DBAR)

Anemia | Blood Disease

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia

Myeloid Diseases

United States
New York Blood Center

Terminated

New York Blood Center National Cord Blood Program

Lymphoma | Leukemia | Myelodysplasia | Genetic Disease | Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

Anemia, Diamond-Blackfan

United States
Peter MacCallum Cancer Centre, Australia

Recruiting

The Evaluating Multidisciplinary Bone Marrow Failure Care in Bone Marrow Failure and Related Disorders. (EMBRACE)

Aplastic Anemia | Bone Marrow Failure Syndrome

Australia
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia

Steroid-refractory Diamond-Blackfan Anemia (DBA)

United States
Assistance Publique - Hôpitaux de Paris

Completed

Cord Blood Transplantation in Severe Aplastic Anemia (APCORD)

Hereditary Diseases | Relapse | Acquired Aplastic Anemia | Absence of an HLA Identical Donor

France
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Danazol for Genetic Bone Marrow and Lung Disorders

Aplastic Anemia

United States
Fondazione Italiana Sindromi Mielodisplastiche-ETS

Completed

Identification of Mechanism in the Erythroid Response in Patients With Myelodysplasia Undergoing Chelation Therapy (BIOFER12)

Myelofibrosis | Aplastic Anemia | Myelodysplasia

Italy
Northwestern Memorial Hospital

Unknown

Study of Allogeneic Bone Marrow and T-Cell Depleted, CD34+ Peripheral Blood Stem Cell Transplantation in Patients With Aplastic Anemia

Aplastic Anemia | Graft Versus Host Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia

Thrombocytopenia | Neutropenia | Pancytopenia | Immunosuppresion

United States
M.D. Anderson Cancer Center
Genzyme, a Sanofi Company

Completed

Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Myelodysplastic Syndrome | Aplastic Anemia

United States
Stanford University
University of Alabama at Birmingham; University of Minnesota

Completed

Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs

Sickle Cell Disease | Thalassemia | Diamond-Blackfan Anemia

United States
European Institute of Oncology

Recruiting

Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology

Lymphoma | Leukemia | Aplastic Anemia | Leukemia, Acute | Leukemia, Chronic

Italy
Johns Hopkins All Children's Hospital

Recruiting

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

Severe Aplastic Anemia | Bone Marrow Failure Syndrome | Hemoglobinopathy (Disorder)

United States
University of Alabama at Birmingham

Completed

Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis

Lymphoma | Leukemia | Myelofibrosis | Myelodysplastic Syndrome | Severe Aplastic Anemia | Allogeneic Transplant

United States
UCSF Benioff Children's Hospital Oakland
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Medical... and other collaborators

Completed

Multi-Center Study of Iron Overload: Pilot Study (MCSIO)

Sickle Cell Disease | Thalassemia | Diamond-Blackfan Anemia

United Kingdom, United States, Germany
National Heart, Lung, and Blood Institute (NHLBI)
National Cancer Institute (NCI); National Institute of Allergy and Infectious... and other collaborators

Recruiting

Safety Study of Cord Blood Units for Stem Cell Transplants

Lymphoma | Leukemia | Aplastic Anemia | Myelodysplastic Syndrome (MDS)

United States
M.D. Anderson Cancer Center

Terminated

Blood Transplantation for Patients With Hematologic Malignancies or Bone Marrow Failure States

Leukemia | Aplastic Anemia | Non Hodgkin's Lymphoma

United States
Alberta Children's Hospital
Stollery Children's Hospital

Terminated

Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients

Childhood Cancer | Aplastic Anemia | Metabolic Disorders

Canada
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

MDS (Myelodysplastic Syndrome) | Severe Aplastic Anemia

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Terminated

Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders

Genetic Disorder | Severe Aplastic Anemia | Immunodeficiency Syndrome

United States
National Research Center for Hematology, Russia

Unknown

Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia

Septic Shock | Nonchemotherapy Drug-induced Neutropenia | Neutropenia After Chemotherapy in Oncohematological Patients | Neutropenia in Patients With Aplastic Anemia

Russian Federation
Paul Szabolcs

Recruiting

T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

Sickle Cell Anemia | Diamond-blackfan Anemia | Beta-thalassemia Major

United States
St. Jude Children's Research Hospital

Active, not recruiting

Haploidentical HCT for Severe Aplastic Anemia

Aplastic Anemia | Bone Marrow Failure Syndrome

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Fertility Preservation in Women Who Will Have Gonadotoxic Therapy or Hematopoetic Stem Cell Transplantation, and in Women With Sickle Cell Disease

Stem Cell Transplant | Aplastic Anemia | Hemoglobin

United States
Children's Hospital of Philadelphia
National Cancer Institute (NCI); University of Pennsylvania; City of Hope Medical... and other collaborators

Recruiting

Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors (IAMFIT)

Myelodysplastic Syndromes | Aplastic Anemia | Lymphoblastic Leukemia | Cancer Survivors

United States
National Institute of Dental and Craniofacial Research...

Completed

Oral Manifestations of Aplastic Anemia

Aplastic Anemia

United States
Institute of Hematology & Blood Diseases Hospital

Unknown

Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria (PNH-2012)

Urination Disorders | Thrombosis | Proteinuria | Anemia, Hemolytic | Hemoglobinuria, Paroxysmal | Hemoglobinuria | Paroxysmal Nocturnal Hemoglobinuria | Bone Marrow Failure | Aplastic Anemia,

China
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Antibody Conditioning Regimen For Allogeneic Donor Stem Cell Transplantation Of Patients With Fanconi Anemia (Mafia)

Fanconi Anemia | Severe Aplastic Anemia

United States
Emory University

Withdrawn

Patient-Driven Transfusion Thresholds in Hematological Disorders: A Pilot Study

Hematopoietic and Lymphoid Cell Neoplasm | Leukemia | Anemia | Myelodysplastic Syndrome | Aplastic Anemia | Bone Marrow Failure

United States
BioLineRx, Ltd.

Completed

Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

Aplastic Anemia | Hypoplastic Myelodysplastic Syndrome

United States
Institute of Hematology & Blood Diseases Hospital

Unknown

Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)

Urination Disorders | Thrombosis | Proteinuria | Anemia, Hemolytic | Hemoglobinuria, Paroxysmal | Hemoglobinuria | Paroxysmal Nocturnal Hemoglobinuria | Bone Marrow Failure | Aplastic Anemia,

China

Clinical Trials on Aplastic Anemia

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