Clinical Trials on Accelerated Phase of Disease

Total 20424 results

QuantalX Neuroscience

Completed

Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.

Healthy | Hemorrhage | Cognitive Impairment | Dementia | Fibromyalgia | TBI (Traumatic Brain Injury) | Cognitive Decline | Concussion, Brain | MS (Multiple Sclerosis) | Adhd | CVA | ABD | Mci

Israel
M.D. Anderson Cancer Center
Merck Sharp & Dohme LLC

Terminated

Chemoradiation-Induced Nausea and Emesis: Quality of Life

Cervical Cancer | Gastric Cancer | Pancreatic Cancer | Vulvar Cancer | Endometrial Cancer | Anal Cancer

United States
Culicchia Neurological Clinic
Flowonix Medical

Recruiting

Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)

Traumatic Brain Injury | Muscle Spasticity | CVA (Cerebrovascular Accident) | Cerebral Palsy, Spastic | MS (Multiple Sclerosis) | Injuries, Spinal Cord

United States
William Gahl, M.D.
National Human Genome Research Institute (NHGRI)

Completed

Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome

Pulmonary Fibrosis | Inborn Errors of Metabolism | Albinism | Oculocutaneous Albinism | Platelet Storage Pool Deficiency

United States
Joseph B. Ciolino, MD

Completed

Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis

Autoimmune Diseases | Rheumatoid Arthritis | Lupus Erythematosus, Systemic | Ocular Cicatricial Pemphigoid | Stevens Johnson Syndrome | Chemical Injuries | Unspecified Complication of Corneal Transplant | Other Autoimmune Diseases

United States
Compass Therapeutics

Recruiting

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Hodgkin Lymphoma | Non Small Cell Lung Cancer | Triple Negative Breast Cancer | Head and Neck Squamous Cell Carcinoma | Malignant Melanoma

United States
Emory University
National Cancer Institute (NCI); NovoCure Ltd.

Recruiting

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases

Metastatic Melanoma | Melanoma of Unknown Primary | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Mucosal Melanoma | Metastatic Ocular Melanoma

United States
Johns Hopkins University
National Institute on Aging (NIA)

Active, not recruiting

Sight and Hearing Investigation Into Effects on Delirium (SHIELD)

Delirium | Delirium on Emergence | Hearing Loss | Hearing Loss, High-Frequency | Hearing Loss, Sensorineural | Delirium, Cause Unknown | Hearing Loss, Bilateral | Hearing Disability | Delirium in Old Age | Delirium of Mixed Origin | Delirium Superimposed on Dementia | Delirium Confusional State | Delirium With... and other conditions

United States
Children's Hospital Medical Center, Cincinnati
Patient-Centered Outcomes Research Institute; Children's Hospital Colorado; Nationwide... and other collaborators

Completed

Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI

Wounds and Injuries | Brain Injuries | Craniocerebral Trauma | Trauma, Nervous System | Brain Concussion | Head Injuries, Closed | Head Injury | Brain Edema | Disorders of Environmental Origin | Brain Hemorrhage, Traumatic | Subdural Hematoma | Epidural Hematoma | Intracranial Edema | Tbi | Cortical Contusion

United States
Guangxi Medical University

Not yet recruiting

Fluzoparib With or Without Apatinib in Platinum-sensitive Relapsed Ovarian Cancer Previously Treated With PARPi

Ovarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Carcinoma | High Grade Serous Adenocarcinoma of Ovary

China
Rigshospitalet, Denmark

Recruiting

Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study (PolyImPAct)

Polyneuropathies | Diabetic Polyneuropathy | Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) | POEMS Syndrome | Multifocal Motor Neuropathy | Charcot-Marie-Tooth | hATTR Amyloidosis | Vasculitic Neuropathy | Idiopathic Neuropathy

Denmark
University of Zurich

Recruiting

Cerebrovascular Disease: Quality of Life (CODE: QoL) (CODE:QoL)

Cerebrovascular Disorders | Quality of Life | Stress | Transient Ischemic Attack | Caregiver Burden | Sexual Behavior | Stroke, Acute | Intracerebral Hemorrhage | Incontinence, Urinary | Cortisol Excess

Switzerland
National Cancer Institute (NCI)

Completed

Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies

Non-Small-Cell Lung Carcinoma | Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura | Advanced Esophageal Cancers | Primary Small Cell Lung Cancers | Pleural Mesotheliomas

United States
University of Washington
Blaze Bioscience Inc.

Recruiting

A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery

Stage III Lip and Oral Cavity Cancer AJCC v8 | Oral Cavity Squamous Cell Carcinoma | Stage I Lip and Oral Cavity Cancer AJCC v8 | Stage II Lip and Oral Cavity Cancer AJCC v8 | Stage IVA Lip and Oral Cavity Cancer AJCC v8

United States
Instil Bio

Withdrawn

ITIL-168 in Advanced Solid Tumors (DELTA-2)

Cervical Cancer | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma
Lawson Health Research Institute

Active, not recruiting

Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus.

Carcinosarcoma | Endometrioid Adenocarcinoma | Clear Cell Carcinoma | Serous Carcinoma | Dedifferentiated Carcinoma

Canada
Masonic Cancer Center, University of Minnesota

Withdrawn

T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in Hematologic Malignancies

Follicular Lymphoma | Acute Myeloid Leukemia | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Acute Lymphocytic Leukemia | Mantle-Cell Lymphoma | Hematologic Malignancy | Small Lymphocytic Lymphoma | Burkitt's Lymphoma | Marginal Zone B-cell Lymphoma | Chronic Myeloproliferative... and other conditions

United States
Nektar Therapeutics

Completed

Study of NKTR 255 in Combination With Cetuximab in Solid Tumors

Cervical Cancer | Colorectal Cancer | Head and Neck Squamous Cell Carcinoma | Anal Squamous Cell Carcinoma | Cutaneous Squamous Cell Carcinoma

United States
Eunice Kennedy Shriver National Institute of Child...

Recruiting

Functional Near-Infrared Spectroscopy (fNIRS) Combined With Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls

Niemann-Pick Disease Type C1 | Juvenile Neuronal Ceroid Lipofuscinosis | Smith-Lemli-Opitz Syndrome | Creatine Transporter Deficiency

United States
University Health Network, Toronto

Unknown

Diagnosing Frontotemporal Lobar Degeneration

Progressive Supranuclear Palsy | Semantic Dementia | Corticobasal Syndrome | Progressive Nonfluent Aphasia | Behavioral Variant Frontotemporal Dementia | Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia

Canada
Mayo Clinic

Terminated

COVID-19 Vaccination in Rheumatic Disease Patients

Osteoarthritis | Systemic Lupus Erythematosus | Psoriatic Arthritis | Sjogren's Syndrome | Gout | Ankylosing Spondylitis | Inflammatory Myositis | Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis)

United States
Fundación Española de Hematología y Hemoterapía

Recruiting

GammaGA: Prevalence of Acid Sphingomyelinase Deficiency Disease (ASMD) and Gaucher Disease in Patients With Monoclonal Gammopathies and/or Multiple Myeloma

Gaucher Disease | Acid SphingoMyelinase Deficiency

Spain
Centre hospitalier de l'Université de Montréal...

Recruiting

Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer. (Ronco-Onco)

Snoring | Sleep Apnea | Oral Cancer | Oral Squamous Cell Carcinoma | Pharynx Cancer

Canada
AbbVie

Terminated

A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely to Exhibit Elevated Levels of Epidermal Growth Factor Receptor

Glioblastoma Multiforme | Triple Negative Breast Cancer | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Colorectal Carcinoma

United States, Spain
Merck Sharp & Dohme LLC
Quintiles, Inc.

Completed

Study to Evaluate the Efficacy and Safety of Temozolomide in Subjects With Brain Metastases of Either Malignant Melanoma, Breast, or Non-small Cell Lung Cancer (P02064)

Melanoma | Carcinoma, Non-Small-Cell Lung | Breast Neoplasm | Metastases of Central Nervous System
Jennifer Choe
Arcus Biosciences, Inc.

Withdrawn

A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers (PANTHEoN)

Head and Neck Cancer | Squamous Cell Carcinoma of Head and Neck | Oropharynx Cancer | Oral Cavity Cancer | Oropharynx Squamous Cell Carcinoma | Pharynx Cancer | Larynx Cancer | Hypopharynx Cancer | Oral Cavity Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma

United States
Sun Yat-sen University

Not yet recruiting

First-line Maintenance Treatment With Fluzoparib Plus Bevacizumab in Advanced BRCA Wild Type Ovarian Cancer

Ovarian Cancer | Primary Peritoneal Cancer | High Grade Serous Adenocarcinoma of Ovary | High Grade Endometrioid Ovarian Cancer | Fallopian-tube Cancer

China
St. Jude Children's Research Hospital
University of Florida; University of Tennessee; Nemours Children's Clinic

Active, not recruiting

Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

Desmoplastic Small Round Cell Tumor | Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Ewing Sarcoma of Bone or Soft Tissue | Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

United States
National Cancer Institute (NCI)

Active, not recruiting

Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Lung Adenocarcinoma | Lung Large Cell Carcinoma | Stage IIIA Lung Non-Small Cell Cancer AJCC v7 | Minimally Invasive Lung Adenocarcinoma | Stage IIIB Lung Non-Small Cell Cancer AJCC v7 | Stage III Lung Non-Small Cell Cancer AJCC v7 | Lung Squamous Cell Carcinoma | Lung Adenocarcinoma, Mixed Subtype

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Recruiting

Phenotype, Genotype and Biomarkers 2 (PGB2)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | Hereditary Spastic Paraplegia

United States, South Africa
Oslo University Hospital

Recruiting

Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders (MITRIC)

Clear Cell Renal Cell Carcinoma | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Melanoma Stage IV | Cutaneous Squamous Cell Carcinoma | MSI-High

Norway
Mayo Clinic
National Cancer Institute (NCI)

Completed

Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer

Human Papillomavirus Infection | Stage IVA Oropharyngeal Squamous Cell Carcinoma | Stage IVB Oropharyngeal Squamous Cell Carcinoma | Stage I Oropharyngeal Squamous Cell Carcinoma | Stage II Oropharyngeal Squamous Cell Carcinoma | Stage III Oropharyngeal Squamous Cell Carcinoma

United States
Frederic Amant
Kom Op Tegen Kanker; Research Foundation Flanders

Completed

FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study (FUCHSia)

Endometrial Cancer | Endometrial Stromal Sarcoma | Sex Cord Stromal Tumor | Adenosarcoma of Uterus | Leiomyosarcoma Uterus | Serous Ovarian Tumor

Belgium, Netherlands
Jennifer Woyach
Janssen Scientific Affairs, LLC

Completed

Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Monoclonal Gammopathy of Undetermined Significance | Myelodysplastic Syndrome | Aplastic Anemia | Symptomatic COVID-19 Infection Laboratory-Confirmed | Monoclonal B-Cell Lymphocytosis

United States
National Cancer Institute (NCI)

Withdrawn

Obatoclax Mesylate, Rituximab, and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Splenic Marginal Zone Lymphoma

United States
University of Pennsylvania
United States Department of Defense; National Institutes of Health (NIH); National... and other collaborators

Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease (UNICORN)

Frontotemporal Degeneration(FTD) | Primary Progressive Aphasia(PPA) | Familial Frontotemporal Lobar Degeneration (fFTLD) | Amyotrophic Lateral Sclerosis(ALS) | Lewy Body Disease(LBD) | Progressive Supranuclear Palsy(PSP) | Corticobasal Syndrome(CBS) | Posterior Cortical Atrophy(PCA) | Alzheimer's Disease(AD)

United States
Metamorphosis LTD

Completed

Stellate Ganglion Block to Treat Long COVID 19 Case Series

Pain | Muscle Pain | Cough | Dizziness | Anosmia | Post-COVID-19 Syndrome | Dysautonomia | Post Acute COVID-19 Syndrome | Long COVID | Long Covid19 | Dysgeusia | Shortness of Breath | Menstrual Cycle Abnormal | Brain Fog | Fatigue Post Viral

United States
Wayne State University
Blue Cross Blue Shield of Michigan Foundation

Unknown

Timing of Acute Palliative Care Consultation in Critically Ill Patients

Multiple Sclerosis | Sepsis | Hepatic Encephalopathy | Parkinson's Disease | Dementia | Multiple Organ Failure | Chronic Kidney Disease Stage 5 | Solid Organ Cancer | End Stage Chronic Obstructive Airways Disease | In-Hospital Cardiac Arrest | End Stage Cardiac Failure

United States
O & O Alpan LLC

Unknown

Investigating Lysosomal Storage Diseases in Minority Groups

Fabry Disease | Niemann-Pick Disease | Gaucher Disease | Pompe Disease | Lysosomal Storage Disorders

United States
MacroGenics

Active, not recruiting

A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors (Tamarack)

Melanoma | Non-small Cell Lung Cancer | Small-cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Anal Cancer | Malignant Melanoma | Non-small Cell Carcinoma | Oral Squamous Cell Carcinoma | Small Cell Carcinoma | Laryngeal Squamous Cell Carcinoma | Carcinoma, Squamous Cell of Head and Neck | Castration-Resistant... and other conditions

Spain, Australia, United States, Korea, Republic of, France, United Kingdom, Italy, Belgium, Poland
Shirley Ryan AbilityLab

Recruiting

Nomad P-KAFO Study

Multiple Sclerosis | Paralysis | Muscular Dystrophy | Spinal Cord Injuries | Cerebrovascular Accident | Post-polio Syndrome

United States
NRG Oncology
National Cancer Institute (NCI)

Active, not recruiting

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Stage IIIA Non-Small Cell Lung Cancer | Stage IIIB Non-Small Cell Lung Cancer | Lung Adenocarcinoma | Recurrent Non-Small Cell Lung Carcinoma | Adenosquamous Lung Carcinoma | Bronchioloalveolar Carcinoma | Large Cell Lung Carcinoma | Squamous Cell Lung Carcinoma | Non-Small Cell Lung Carcinoma

United States, Canada, Israel
National Cancer Institute (NCI)

Completed

Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma

Recurrent Uterine Corpus Sarcoma | Chondrosarcoma | Recurrent Osteosarcoma | Gastrointestinal Stromal Tumor | Clear Cell Sarcoma of the Kidney | Metastatic Osteosarcoma | Ovarian Sarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage III Uterine Sarcoma | Stage IV Adult... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Acute Erythroid Leukemia | Acute Megakaryoblastic Leukemia | Myelodysplastic Syndrome | Myelodysplastic Syndrome With Excess Blasts | Refractory Anemia | Myelodysplastic Syndrome With Ring Sideroblasts

United States
University of California, San Francisco

Completed

Davunetide (AL-108) in Predicted Tauopathies - Pilot Study

Progressive Supranuclear Palsy | Corticobasal Degeneration Syndrome | Progressive Nonfluent Aphasia | Predicted Tauopathies, Including | Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17

United States
Dartmouth-Hitchcock Medical Center

Completed

Neurology Inpatient Clinical Education Trial

Multiple Sclerosis | Encephalitis | Seizures | Headache | Myasthenia Gravis | Meningitis | Parkinsonism | Spondylosis | Guillain-Barre Syndrome | Vestibular Disorder | Normal Pressure Hydrocephalus

United States
Azienda Sanitaria-Universitaria Integrata di Udine

Recruiting

Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study. (ODISSEA)

Quality of Life | Covid19 | Post Traumatic Stress Disorder

Italy
GOG Foundation
National Cancer Institute (NCI)

Active, not recruiting

Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical Cancer

Lymphedema | Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma | Stage IA2 Cervical Cancer AJCC v6 and v7 | Stage IB1 Cervical Cancer AJCC v6 and v7 | Stage IA1 Cervical Cancer AJCC v6 and v7

United States, Korea, Republic of, Canada
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); Dana-Farber Cancer Institute

Completed

Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas

Sarcoma | Small Intestine Cancer | Ovarian Cancer | Endometrial Cancer | Desmoid Tumor | Adult Malignant Fibrous Histiocytoma of Bone

United States
NGM Biopharmaceuticals, Inc
Merck Sharp & Dohme LLC

Recruiting

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Breast Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Prostate Cancer | Mesothelioma | Squamous Cell Carcinoma of Head and Neck | Cholangiocarcinoma | Non-small Cell Lung Cancer | Colorectal Carcinoma | Bladder Urothelial Cancer | Endocervical...

United States

Clinical Trials on Accelerated Phase of Disease

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