Clinical Trials on Activating Mutations
Total 1062 results
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Lille Catholic UniversityRecruitingEhlers Danlos Hypermobile SyndromeFrance
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Swedish Orphan BiovitrumRecruitingSystemic Lupus Erythematosus | Macrophage Activation Syndrome | Still Disease | Secondary Hemophagocytic Lymphohistiocytosis | SJIA | AOSD | MASUnited States, Belgium, Italy, Netherlands, United Kingdom, China, France, Spain, Czechia, Canada, Sweden, Japan, Germany, Poland
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The Netherlands Cancer InstituteDaiichi Sankyo, Inc.Not yet recruitingEGFR Gene Mutation | Non-Small Cell Lung Carcinoma | Advanced Non-Small Cell Squamous Lung Cancer
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NYU Langone HealthRecruitingNon-small Cell Lung Cancer With STK11/LKB1 MutationUnited States
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Ludwig-Maximilians - University of MunichCharité Universitätsmedizin, Department of Hematology, Oncology and Tumor...Not yet recruitingMetastatic Colorectal Cancer | Multidisciplinary Communication | RAS Mutation | Secondary Intervention
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Jiangsu HengRui Medicine Co., Ltd.Shanghai Chest HospitalUnknownChemotherapy Effect | KRAS Gene Mutation | NSCLC Stage IV | PD-1 Antibody
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Samsung Medical CenterAstraZenecaUnknownEGFR Mutation Positive Non-small Cell Lung CancerKorea, Republic of
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Fundación GECPRecruitingNon Small Cell Lung Cancer | EGFR Gene MutationSpain
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Astellas Pharma Global Development, Inc.RecruitingAcute Myeloid Leukemia (AML) | Acute Myeloid Leukemia With FMS-like Tyrosine Kinase 3 (FLT3) Mutation / Internal Tandem Duplication (ITD)United States, Canada, Germany, Italy, Spain, United Kingdom, France
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Sun Yat-sen UniversityRecruitingLymphoma, Non-Hodgkin | Pediatric Cancer | Lymphoblastic Lymphoma, Childhood | PTEN Loss | NOTCH1 Gene MutationChina
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Massachusetts General HospitalNational Cancer Institute (NCI)Active, not recruitingLow Grade Glioma | WHO Grade 3 Glioma With IDH1 Mutation | WHO Grade 3 Glioma With 1p/19q CodeletionUnited States
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Beijing Tiantan HospitalRactigen TherapeuticsEnrolling by invitation
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Hope Biosciences Stem Cell Research FoundationHope BiosciencesNo longer availableCongenital Muscular Dystrophy Due to Lamin A/C MutationUnited States
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European Organisation for Research and Treatment...Active, not recruitingEGFR Mutation Positive Non Small Cell Lung CancerUnited Kingdom
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Scorpion Therapeutics, Inc.RecruitingNon-Small Cell Lung Cancer | NSCLC | EGFR/HER2 Exon 20 Insertion MutationUnited States, Taiwan
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Taiho Oncology, Inc.RecruitingAdvanced or Metastatic NSCLS With Exon 20 Insertion MutationUnited States, Spain, Canada, Italy, Israel, Japan, United Kingdom, Korea, Republic of, Germany, France, Turkey, Belgium, Netherlands, Philippines, Poland, Singapore
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Shanghai Pulmonary Hospital, Shanghai, ChinaRecruitingEGFR Gene Mutation | Lung Adenocarcinoma Stage III | Lung Adenocarcinoma Stage IVChina
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Shanghai JMT-Bio Inc.Active, not recruitingLocal Advanced or Metastatic NSCLC | Harboring EGFR Common MutationChina
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Spanish Lung Cancer GroupTerminatedNon Small Cell Lung Cancer | BRCA1 MutationSpain
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Boston Children's HospitalEunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaboratorsCompletedPTEN Gene Mutation | PTEN Hamartoma Tumor SyndromeUnited States
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National Heart, Lung, and Blood Institute (NHLBI)CompletedMitochondrial Disorders | Li-Fraumeni Syndrome | Carriers of p53 MutationUnited States
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Ohio State University Comprehensive Cancer CenterImmunoGen, Inc.; Clovis Oncology, Inc.Active, not recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Folate Receptor Alpha Positive | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Recurrent Uterine Serous Carcinoma | Recurrent Uterine Carcinosarcoma | Platinum...United States
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Children's Hospital of Soochow UniversityRecruitingAML, Childhood | C-KIT Mutation | Refractory AML | Relapse/Recurrence | Core Binding Factor Acute Myeloid LeukemiaChina
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Betta Pharmaceuticals Co., Ltd.RecruitingNon-Small Cell Lung Cancer | Adjuvant Therapy | EGFR Sensitive MutationChina
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University Hospital, Basel, SwitzerlandRecruiting
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Wei XuRecruitingChemotherapy Effect | Gene Mutation-Related Cancer | Tislelizumab | Cancer of Unknown Primary | Bone Cancer Metastatic | Immune Evasion, TumorChina
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Novartis PharmaceuticalsCompletedChronic Myeloid Leukemia With T315I MutationSwitzerland
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Jonsson Comprehensive Cancer CenterAstraZenecaActive, not recruitingGlioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | Supratentorial Glioblastoma | EGFR Gene Amplification | TP53 wt AlleleUnited States
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Alpha Biopharma (Jiangsu) Co., Ltd.CompletedNon-small Cell Lung Cancer | Brain Metastases | EGFR Gene MutationChina, Korea, Republic of, Singapore, Taiwan
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Scripps HealthJ. Craig Venter InstituteCompletedLi-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation CarrierUnited States
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Vertex Pharmaceuticals IncorporatedCompletedCystic Fibrosis, Homozygous for the F508del CFTR MutationUnited States, Germany, Canada, Netherlands, Czech Republic, Italy, Ireland, Sweden, United Kingdom, Australia, France
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University of FloridaNot yet recruitingAmputations for Management of Sarcoma,Trauma,or Chronic Infection
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Prof. Dr. Cemil Tascıoglu Education and Research...Completed
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Guangdong Provincial People's HospitalRecruitingNon Small Cell Lung Cancer | EGFR Gene MutationChina
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University of AarhusRecruitingCystic Fibrosis (CF) | CFTR Gene MutationDenmark
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Nir PeledNot yet recruitingNon Small Cell Lung Cancer | EGFR Gene Mutation | Immune Checkpoint InhibitorIsrael
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Pusan National University HospitalRecruitingNon Small Cell Lung Cancer | EGFR Gene MutationKorea, Republic of
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Intergroupe Francophone de Cancerologie ThoraciqueRecruitingNon Small Cell Lung Cancer | ALK Gene MutationFrance
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Cullinan Therapeutics Inc.RecruitingNon Small Cell Lung Cancer | EGFR Exon 20 MutationUnited States, Taiwan, Spain, Korea, Republic of, Japan, Singapore, Italy, Netherlands, Hong Kong
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Dana-Farber Cancer InstituteAbbVie; Pharmacyclics LLC.Active, not recruitingWaldenstrom Macroglobulinemia | MYD88 Gene MutationUnited States
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PTC TherapeuticsCompletedNonsene Mutation Duchenne Muscular DystrophyUnited States
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Memorial Sloan Kettering Cancer CenterCompletedNon Small Cell Lung Cancer | KRAS Gene MutationUnited States
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SciClone PharmaceuticalsUnknownEGFR Mutation Positive Non Small Cell Lung CancerItaly
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Radiotherapy Oncology Centre "Santa Maria" HospitalPaola Anselmo,MD; Michelina Casale,PhD; Fabio Trippa,MDRecruitingNSCLC | Non Small Cell Lung Cancer | EGF-R Positive Non-Small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic | NSCLC Stage IV | Oligometastatic Disease | Non-Small Cell Squamous Lung Cancer | Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor | Non-Small Cell Adenocarcinoma and other conditionsItaly
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Novartis PharmaceuticalsTerminatedc-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBMSpain, Switzerland, Germany, United States, Netherlands
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University of Texas Southwestern Medical CenterCompletedAnatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Prognostic... and other conditionsUnited States
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University of UtahTerminatedSpinal Cord Injury | Peripheral Nerve Injury | AmputationsUnited States
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Groupe Français de Pneumo-CancérologieRecruitingMechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion (RESAMEX)Non-small Cell Lung Cancer | EGFR Exon 20 Insertion MutationFrance
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Daping Hospital and the Research Institute of Surgery...Not yet recruitingNon Small Cell Lung Cancer | EGFR Gene Mutation
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Kura Oncology, Inc.RecruitingNeoplasms by Histologic Type | Acute Myeloid Leukemia | Leukemia | Leukemia, Myeloid | Leukemia, Myeloid, Acute | AML | Acute Leukemia | Hematologic Malignancy | NPM1 Mutation | AML With Mutated NPM1 | KMT2Ar | MLL RearrangementUnited States