Clinical Trials on Advanced Malignancy

Total 9693 results

Tianhong Li
National Cancer Institute (NCI); LabyRx Immunologic Therapeutics

Recruiting

A Cancer Vaccine (Labvax 3(22)-23) and GM-CSF Alone or in Combination With Pembrolizumab for the Treatment of Advanced Stage Adenocarcinoma

Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Adenocarcinoma | Advanced Adenocarcinoma | Recurrent Adenocarcinoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm

United States
Cancer Institute and Hospital, Chinese Academy...

Completed

Trial of Pemetrexed in Combined With Cisplatin for the Treatment of Advanced Breast Cancer

Locally Advanced Malignant Neoplasm

China
Epizyme, Inc.
Sponsor GmbH

Recruiting

A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Hepatic Impairment | Advanced Malignant Solid Tumor

France, Belgium, United States, Poland, Slovakia
Mirati Therapeutics Inc.

Approved for marketing

Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation

Metastatic Cancer | Advanced Cancer | Malignant Neoplasm

United States
National Cancer Institute (NCI)

Not yet recruiting

Studying TAK-243 in Patients With Advanced Cancer

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm
SingHealth Polyclinics

Completed

Increasing the Uptake of Advanced Directives in SingHealth Polyclinics

Advanced Medical Directive, a Legal Document Signed in Advance to State Healthcare Preferences

Singapore
M.D. Anderson Cancer Center

Suspended

Assessment of Verbal Comprehension and Cognitive Processes in Patients Admitted to the Palliative and Supportive Care Unit

Hematopoietic and Lymphoid Cell Neoplasm | Locally Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Sameek Roychowdhury

Active, not recruiting

Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations

Cholangiocarcinoma | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Shanghai Yuyao Biotech Co., Ltd.

Recruiting

An Open-Label, Multicenter, Phase I Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of YY201 in Patients With Advanced Solid Tumors and Hematological Malignancies

Advanced Solid Tumor | Hematological Malignancy

China
OncoMed Pharmaceuticals, Inc.

Terminated

A Study of OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors

Metastatic Cancer | Locally Advanced Malignant Neoplasm

United States
Hutchison Medipharma Limited

Recruiting

HMPL-453 in Advanced Malignant Mesothelioma

Advanced Malignant Mesothelioma

China
Constellation Pharmaceuticals

Not yet recruiting

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

Solid Tumor | Hematologic Malignancy | Advanced Malignancies
Constellation Pharmaceuticals

Completed

Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies

Solid Tumor | Advanced Malignancies | Hematological Malignancy

Spain, United States, Georgia
M.D. Anderson Cancer Center

Completed

Bevacizumab and Bortezomib in Patients With Advanced Malignancy

Lymphoma | Solid Tumors | Myeloma | Advanced Malignancy

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Completed

Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab

Advanced Malignant Neoplasm | Dermatologic Complication

United States
EpicentRx, Inc.

Terminated

RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD) (PAYLOAD)

Metastatic Cancer | Advanced Cancer | Malignant Solid Tumor

United States
University Health Network, Toronto
Canadian Association of Radiation Oncology

Completed

Healthy Bones Study

Locally Advanced Malignant Neoplasm

Canada
Puma Biotechnology, Inc.

Completed

A Phase 1/2 Study of HKI-272 (Neratinib) in Combination With Paclitaxel (Taxol) in Subjects With Solid Tumors and Breast Cancer

Breast Neoplasms | Advanced Breast Cancer | Advanced Malignant Solid Tumors

United States, Belgium, China, Hong Kong, Canada, Korea, Republic of, India, Poland, Ukraine
Polaris Group

Terminated

Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin (TRAP)

Glioma | Hepatocellular Carcinoma | Uveal Melanoma | Sarcomatoid Carcinoma | Pleural Mesothelioma Malignant Advanced | Peritoneal Mesothelioma Malignant Advanced | Non-squamous Non-small Cell Lung Carcinoma

United States, United Kingdom
Duke University

Terminated

Procedural Outcomes in Endobronchial Ultrasound - Transbronchial Needle Aspiration (EBUS-TBNA) With and Without Rapid On-Site Evaluation (ROSE) (ROSE)

ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION | Benign and Malignant Mediastinal and Hilar Lymph Nodes Known or Suspected Malignancy

United States
Akeso

Not yet recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK114

Metastasis | Advanced or Metastatic Solid Tumors | Malignancy

Australia
Helsinki University Central Hospital

Recruiting

The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs (FINPROVE)

Solid Tumor | Advanced Cancer | Haematological Malignancy

Finland
Peking University

Recruiting

UTAA06 Injection for Treatment of Advanced Malignant Solid Tumors

Conditions or Focus of Study: B7-H3 Positive Relapsed/Advanced Malignant Solid Tumor

China
Kartos Therapeutics, Inc.
GlaxoSmithKline

Completed

A Phase 1b/2a Study Evaluating AMG 232 in Metastatic Melanoma

Melanoma | Cancer | Advanced Solid Tumors | Oncology | Tumors | Advanced Malignancy | Oncology Patients

United States, Australia
Daiichi Sankyo, Inc.

Completed

Study to Assess the Safety and Tolerability of U3-1565 in Subjects With Advanced Solid Malignant Tumors

Advanced Solid Malignant Tumors | Advanced Ovarian Cancer

United States
Aadi Bioscience, Inc.

Active, not recruiting

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Malignant Solid Neoplasm | Neoplasms | Cancer | Neoplasm Metastasis | Solid Tumor | Metastatic Cancer | Metastasis | Advanced Solid Tumor | Metastatic Solid Tumor | Advanced Cancer | Tumor | Malignant Neoplasm | Malignant Tumor | Tumors | Cancer Metastatic | Tumor, Solid | Malignant Solid Tumor | TSC | TSC1 | TSC2 | Metastatic Neoplasm

United States, Korea, Republic of, Puerto Rico
Fred Hutchinson Cancer Center
National Institute of Nursing Research (NINR); Peacefully, Inc.

Recruiting

Design and Testing of a Web-Based Tool for the Improvement of End-of-Life Planning in Patients With Advanced Cancer

Hematopoietic and Lymphoid System Neoplasm | Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
University of Southern California
National Cancer Institute (NCI)

Recruiting

Short-term Fasting Prior to PD-1/PD-L1 Inhibitor Therapy for of Advanced or Metastatic Skin Malignancy

Advanced Malignant Skin Neoplasm | Metastatic Malignant Skin Neoplasm

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Palbociclib (PD-0332991) as a Potential Targeted Treatment in Cancers With CCND1, 2, 3 Amplification (MATCH-Subprotocol Z1B)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm

United States
St Vincent's University Hospital, Ireland

Recruiting

A Contemporary Review of Surgical Approaches in Pelvic Exenterative Surgery

Locally Advanced Rectal Cancer | Pelvic Exenteration | Advanced Pelvic Malignancy

Ireland
National Cancer Institute (NCI)

Active, not recruiting

Testing the Biological Effects of DS-8201a on Patients With Advanced Cancer

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | HER2-Positive Breast Carcinoma

United States
Syndax Pharmaceuticals

Completed

A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumors

Solid Tumor | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | Metastatic Tumor

United States
M.D. Anderson Cancer Center

Active, not recruiting

Patient Considerations of Social Media Account Management After Death

Advanced Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Innovent Biologics (Suzhou) Co. Ltd.

Completed

A Phase 1a Study Evaluating the Safety, Tolerability, and Efficacy of IBI322 in Subjects With Advanced Cancers

Advanced Malignant Tumors Lymphomas

United States
Kartos Therapeutics, Inc.

Completed

A Phase 1b Study Evaluating AMG 232 Alone and in Combination With Trametinib in Acute Myeloid Leukemia

Acute Myeloid Leukemia | Cancer | Oncology | Advanced Malignancy | Oncology Patients

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors

Weight Loss | Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Cancer Fatigue | C-Reactive Protein Measurement

United States
Providence Health & Services
Eli Lilly and Company

Completed

Chemoimmunotherapy and Radiation in Pancreatic Cancer (CRIT)

Locally Advanced Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | KRAS Gene Mutation | Metastatic Malignant Solid Neoplasm | EGFR Gene Mutation | ERBB2 Gene Amplification | ERBB2 Gene Mutation | EGFR Gene Amplification | ERBB3 Gene Mutation | ERBB4 Gene Mutation

United States
Suzhou Transcenta Therapeutics Co., Ltd.

Terminated

Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors

Locally Advanced or Metastatic Cancers | Metastatic Human Papillomavirus-Related Malignant Neoplasm

United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Study of TQB2450 Combined With Anlotinib in Subjects With Advanced Acral Malignant Melanoma

Advanced Acral Malignant Melanoma

China
Bayer

Completed

First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin

Advanced Recurrent Malignant Pleural Epithelioid Mesothelioma | Advanced Recurrent Malignant Peritoneal Epithelioid Mesothelioma | Advanced Recurrent Serous Ovarian Cancer | Advanced Pancreatic Ductal Adenocarcinoma (Optional, Dose Expansion, Not Initiated)

United States, Sweden, Netherlands, United Kingdom, Finland
InnoPharmax Inc.

Completed

Phase1 Study of Gemcitabine HCl Oral Formulation(D07001-F4) in Patients With Advanced Solid Malignancies and Malignant Lymphomas

Advanced Solid Malignancies | Malignant Lymphomas

Taiwan
University of Southern California
National Cancer Institute (NCI); Auransa, Inc.

Recruiting

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Advanced Hepatocellular Carcinoma | Metastatic Malignant Neoplasm in the Liver | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Advanced Cholangiocarcinoma

United States
M.D. Anderson Cancer Center

Terminated

Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

Advanced Cancers | Malignant Pleural Effusions

United States
Jonsson Comprehensive Cancer Center
California Institute for Regenerative Medicine (CIRM)

Terminated

Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer (NYESO SCT)

Sarcoma | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | HLA-A*0201 Positive Cells Present | NY-ESO-1 Positive

United States
Institut Cancerologie de l'Ouest

Recruiting

Impact of the Coordinated Intervention of the Healthcare Facilities Pharmacist and the Dispensary Pharmacist on the Care Pathway for Cancer Patients Treated With Oral Therapy (IPPACTTO)

Relapsed Hematologic Malignancy | Advanced or Metastatic Solid Tumor

France
Hospital Italiano de Buenos Aires

Completed

ALPPS: Safety, Feasibility and Efficacy at a Single Center

Locally Advanced Malignant Liver Disease

Argentina
Tasly Tianjin Biopharmaceutical Co., Ltd.

Unknown

Safety, Tolerability and Pharmacokinetics Characteristics of Recombinant Oncolytic Vaccinia Virus Injection T601 as a Single Drug or in Combination With Oral Flucytosine (5-FC), in Patients With Advanced Malignant Solid Tumors

Advanced Malignant Solid Tumors

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

Hematopoietic and Lymphoid Cell Neoplasm | Anorexia | Advanced Malignant Solid Neoplasm

United States

Clinical Trials on Advanced Malignancy

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