Clinical Trials on Anemia, Hemolytic, Congenital

Total 11821 results

Institute of Hematology & Blood Diseases Hospital...
Suzhou Fundamenta Therapeutics

Recruiting

CAR-T for Autoimmune Hemolytic Anemia Patients Who Have Failed Three or More Lines of Therapy

Autoimmune Hemolytic Anemia | CD19 CAR-T Cell Infusion

China
GlaxoSmithKline

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years

Hematologic Diseases | Anaemia, Sickle Cell

United States
Wolfson Medical Center

Unknown

Hemolysis in Patients With Hereditary Spherocytosis (HS)

Hemolysis | Hereditary

Israel
Institute of Hematology & Blood Diseases Hospital...
YL-Pharma

Terminated

PI3K Delta Inhibitor in Relapsed / Refractory Autoimmune Hemolytic Anemia Patients After Receiving Two or More Lines of Therapy

Autoimmune Hemolytic Anemia | Failure of Two Rounds of Treatment

China
Ain Shams University

Completed

Congenital Heart Surgery in Pediatric Patients With Beta-Thalassemia Major

Hemolysis
Indonesia University

Completed

The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major

Hemolysis | Oxidative Stress | Beta Thalassemia Major Anemia

Indonesia
Massachusetts General Hospital
Agios Pharmaceuticals, Inc.

Recruiting

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm | Clonal Cytopenia of Undetermined Significance | Pyruvate Kinase Deficiency | Pyruvate Kinase Deficiency Anemia | Hereditary Hemolytic Anemia | Clonal Myeloid Neoplasm | Other... and other conditions

United States
Apellis Pharmaceuticals, Inc.

Completed

Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD)

Cold Agglutinin Disease | Warm Autoimmune Hemolytic Anemia

United States
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
University Hospital, Udine, Italy

Completed

A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia

Autoimmune Hemolytic Disease (Cold Type) (Warm Type)

Italy
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders

Sickle Cell Disease | Sickle Cell Anemia | Chronic Hemolytic Disorders

United States
Helse Fonna

Completed

Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease (CAD5)

Autoimmune Hemolytic Anemia | Cold Agglutinin Disease

Finland, Denmark, Norway
Mario Negri Institute for Pharmacological Research

Recruiting

Functional Implications of Rare Gene Mutations in aHUS Open the Door to Personalized Therapy (aHUS-iPSC-EC)

Atypical Hemolytic Uremic Syndrome

Italy
Agios Pharmaceuticals, Inc.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period (ACTIVATE-KidsT)

Pediatric Pyruvate Kinase Deficiency | Pediatric Hemolytic Anemia

United States, Spain, Denmark, Turkey, Netherlands, Czechia, United Kingdom, Germany, Canada, Switzerland
Agios Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period (ACTIVATE-Kids)

Pediatric Pyruvate Kinase Deficiency | Pediatric Hemolytic Anemia

United States, Spain, Germany, Netherlands, Canada, France, Israel, Switzerland, Italy
Fundación Grupo de Investigación en Cuidados Intensivos...
Alexion Pharmaceuticals

Unknown

Usefulness of a Diagnostic Algorithm to Diagnose Thrombotic Microangiopathies in Pregnancy

Hemolytic-Uremic Syndrome

Colombia
Alexion Pharmaceuticals

Completed

Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-Resistant aHUS (aHUS)

Atypical Hemolytic Uremic Syndrome

France, United States, Austria, Germany, United Kingdom
Institute of Hematology & Blood Diseases Hospital...
Juventas Cell Therapy Ltd.

Recruiting

CNCT19 for Patients With Autoimmune Hemolytic Anemia After Failure ≥3 Lines of Therapy.

Autoimmune Hemolytic Anemia | Autologous CD19 CAR-T | Failure of Three or More Lines of Therapy

China
Alexion Pharmaceuticals

Completed

Open Label Controlled Trial of Eculizumab in Adolescent Patients With Plasma Therapy-Resistant aHUS (aHUS)

Atypical Hemolytic Uremic Syndrome

France, United States, Austria, Germany, United Kingdom
Assiut University

Active, not recruiting

Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus | Autoimmune Hemolytic Anemia

Egypt
Alexion

Completed

An Open-label, Multi-center Clinical Trial of Eculizumab in Adult Patients With Atypical Hemolytic-uremic Syndrome

Atypical Hemolytic-Uremic Syndrome

United Kingdom, United States, France, Italy, Germany, Spain, Belgium
Alexion Pharmaceuticals

Completed

An Open-Label, Multi-Center Clinical Trial of Eculizumab in Pediatric Patients With Atypical Hemolytic-Uremic Syndrome (aHUS)

Atypical Hemolytic-Uremic Syndrome

United Kingdom, Belgium, United States, Germany, Italy, France, Netherlands, Australia, Canada
Alexion
Syneos Health

Recruiting

Atypical Hemolytic-Uremic Syndrome (aHUS) Registry

Atypical Hemolytic-Uremic Syndrome

France, Germany, Israel, Italy, United Kingdom, Canada, United States, Australia, Belgium, Denmark, Korea, Republic of, Poland, Russian Federation, Spain, Taiwan
Hospital General de Niños Pedro de Elizalde

Completed

Erythropoietin in Hemolytic Uremic Syndrome

Anemia | Hemolytic-Uremic Syndrome

Argentina
Fundación Grupo de Investigación en Cuidados Intensivos...
Alexion Pharmaceuticals

Unknown

Eculizumab Use in the Postpartum Period for the Treatment of Pregnancy Associated aHUS: A Case Series

Pregnancy | Atypical Hemolytic Uremic Syndrome

Colombia
Nantes University Hospital

Completed

Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS (STOPECU)

Atypical Hemolytic Uremic Syndrome

France
Alexion Pharmaceuticals

Terminated

aHUS Observational Long Term Follow-Up (LTFU)

Atypical Hemolytic Uremic Syndrome

France, Canada, United States, Belgium, Italy, United Kingdom, Netherlands, Australia, Austria, Germany, Sweden, Switzerland
Wolfson Medical Center

Unknown

GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis (GDF 15)

Patients With Thalassemia Intermedia, | Congenital Dyserythropoietic Anemia Type I
Northwell Health

Completed

Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia (LeucineDBA)

Pure Red Cell Aplasia | Diamond Blackfan Anemia | Blackfan Diamond Syndrome | DBA | Congenital Hypoplastic Anemia

United States
Alexion Pharmaceuticals

Completed

The Safety and Efficacy of Eculizumab in Japanese Patients With Atypical Hemolytic Uremic Syndrome (aHUS)

Atypical Hemolytic Uremic Syndrome (aHUS)

Japan
Alexion Pharmaceuticals

Completed

To Characterize the Safety and Tolerability of Eculizumab in Two Japanese aHUS Patients

ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS)

Japan
AO GENERIUM

Completed

Observational Study of Elizaria® in aHUS Patients

Atypical Hemolytic Uremic Syndrome | aHUS

Russian Federation
Alexion Pharmaceuticals

Terminated

Evaluation of Potential Predictors of Disease Progression in Participants With Atypical Hemolytic Uremic Syndrome (aHUS) Including Genetics, Biomarkers, and Treatment (EVIDENCE)

Atypical Hemolytic Uremic Syndrome

United States, Australia, Germany, United Kingdom
University Hospital, Toulouse

Completed

Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU (ECULISHU)

Hemolytic Uremic Syndrome of Childhood

France
Alnylam Pharmaceuticals

Withdrawn

A Study of an Investigational Drug, Cemdisiran (ALN-CC5), in Patients With Atypical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome

Sweden, Moldova, Republic of, Latvia, Lithuania, Estonia, Bosnia and Herzegovina, Canada, Georgia, Macedonia, The Former Yugoslav Republic of, Serbia
Assiut University

Unknown

Outcame of Cases With Hemolytic Uremic Syndrome Attending Assiut University Child Hospital

Hemolytic Uremic Syndrome of Childhood
Alexion

Completed

Open Label Controlled Trial of Eculizumab in Adolescent Patients With Plasma Therapy-Sensitive aHUS (aHUS)

Atypical Hemolytic Uremic Syndrome

Canada, United Kingdom, France, Germany, Netherlands, Sweden, Italy
Centre Hospitalier Universitaire Dijon

Recruiting

Efficacy of Prolonged Anticoagulation for Primary Prevention of Venous Thromboembolic Disease in Autoimmune Hemolytic Anemia: a Prospective, Phase II, Randomized, Multicenter Study (API-AHAI)

Autoimmune Hemolytic Anemia | Venous Thromboembolic Disease | Prolonged Anticoagulation

France
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis

Vasculitis | Amyloidosis | Autoimmune Hemolytic Anemia | POEMS Syndrome

China
ApoPharma

Terminated

Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias

Iron Overload | Sickle Cell Disease | Other Anemias

United States, United Kingdom, Egypt, Canada, Saudi Arabia
ApoPharma

Terminated

Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias (FIRST)

Iron Overload | Sickle Cell Disease | Other Anemias

United States, Turkey, United Kingdom, Egypt, Saudi Arabia, Brazil, Canada, Tunisia
Alexion Pharmaceuticals

Completed

Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-sensitive Atypical Hemolytic Uremic Syndrome (aHUS) (aHUS)

Atypical Hemolytic Uremic Syndrome

Canada, United Kingdom, France, Germany, Sweden, Netherlands, Italy
University Hospital, Ghent

Completed

Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease

Atypical Hemolytic Uraemic Syndrome

Belgium
Emory University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

STRIDE Biorepository

Anemia, Sickle Cell

United States
Peking Union Medical College Hospital

Completed

Single-dose Anti-CD20 Antibody With Bortezomib for Relapsed Refractory Autoimmune Hemolytic Anemia (RRAIHA01)

Autoimmune Hemolytic Anemia | Autoimmune Hemolytic Anemia and Autoimmune Thrombocytopenia

China
Omeros Corporation

Unknown

Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome (aHUS)

Thrombotic Microangiopathies | Atypical Hemolytic Uremic Syndrome

United States
Mario Negri Institute for Pharmacological Research
ChemoCentryx

Terminated

Complement Inhibition in aHUS Dialysis Patients (ACCESS)

Atypical Hemolytic Uremic Syndrome

Italy
Children's Hospital Medical Center, Cincinnati

Withdrawn

Dipyridamole/Magnesium To Improve Sickle Cell Hydration

Anemia, Sickle Cell

United States
Washington University School of Medicine

Terminated

Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases

Anemia, Sickle Cell

United States
HaEmek Medical Center, Israel

Completed

Demographic, Clinical and Laboratory Characteristics of Children With Alpha Thalassemia in Northern Israel

Hemolytic Anemia | Thalassemia Alpha

Israel
Hillhurst Biopharmaceuticals, Inc.
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy Volunteers

Anemia, Sickle Cell

United States

Clinical Trials on Anemia, Hemolytic, Congenital

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