Clinical Trials on Anti-Infective Agents in South Africa

Total 780 results

The University of Queensland

Completed

Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response (MERINO II)

Bloodstream Infections

Singapore, Australia
GlaxoSmithKline

Terminated

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Ascending Intravenous Single Dose and Repeat Dose of GSK3342830

Infections, Bacterial

Australia
The University of Queensland
Queensland Children's Hospital; Griffith University; Royal Brisbane and Women... and other collaborators

Recruiting

Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs) (ProP)

Wound Infection | Catheter Infection | Catheter-Related Infections | Wound | Vascular Access Complication | Catheter Complications | Device Related Infection | Wound of Skin | Catheter Related Complication | Device Related Sepsis | Occlusive Dressings | Device Site Reactions

Australia, France
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Pharmacokinetics of Raltegravir in HIV-1-Exposed Newborn Infants at Risk of Acquiring HIV-1 Infection

HIV Infections

United States, Thailand, Puerto Rico, Brazil, South Africa
Prisma Health-Upstate

Terminated

Diabetic Foot Infection Antibiotic Study

Diabetic Foot Infections

United States
AtoGen Co. Ltd
ATOGEN AUSTRALIA PTY LTD

Recruiting

Safety, Tolerability, and Acceptability Study of Intravaginal Administration of LABTHERA-001 Capsules in Healthy Women

Bacterial Infections | Vaginal Disease | Vaginitis | Infection, Bacterial | Bacterial Vaginosis

Australia
Pfizer
Forest Laboratories

Terminated

Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.

Complicated Skin and Soft Tissue Infection

Croatia, Bulgaria, Italy, Turkey, Romania, Argentina, Brazil, Chile, Israel, Poland, South Africa, Greece, Spain
GlaxoSmithKline

Completed

A Randomized, Single Blind, Placebo Controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses and Repeat Escalating Oral Doses of GSK2251052 in Healthy Adult Subjects

Infections, Bacterial

Australia
Abbott Medical Devices

Completed

Lead Registry for Optim Leads (OPTIMUM)

Optim Lead Insulation Related Adverse Events

United States, Belgium, Germany
University of Adelaide

Completed

The Long-term Impact of Invasive Meningococcal Disease in Australian Adolescents and Young Adults (AMEND)

Meningococcal Infections | Neisseria Infection | Neisseria Meningitis Sepsis

Australia
Maastricht University Medical Center
National Institute for Public Health and the Environment (RIVM); ZonMw: The... and other collaborators

Completed

Transmission of Genital and Extra-genital Chlamydia Trachomatis Infections in Women (FemCure)

Chlamydia Trachomatis Infection

Netherlands
The University of New South Wales
Sydney Children's Hospitals Network; Women's and Children's Hospital, Australia

Completed

Immunogenicity of HPV Vaccine in Immunosuppressed Children

Kidney Transplant Infection | Juvenile Idiopathic Arthritis | Inflammatory Bowel Disease | Autoimmune Disease | Evidence of Liver Transplantation | Bone Marrow Transplant Infection

Australia
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID); Merck Sharp... and other collaborators

Completed

A5288/MULTI-OCTAVE: Management Using Latest Technologies to Optimize Combination Therapy After Viral Failure (MULTI-OCTAVE)

HIV-1 Infection

Kenya, Brazil, South Africa, Uganda, Zimbabwe, India, Malawi, Haiti, Thailand, Peru
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Evaluating Pharmacokinetic Interactions With Vaginal Ring Contraceptives and ART

HIV-1 Infection

United States, Peru, Puerto Rico, Brazil, Botswana, Kenya, South Africa, Thailand
PENTA Foundation
Institut National de la Santé Et de la Recherche Médicale, France; Program... and other collaborators

Active, not recruiting

A Randomised Trial of Dolutegravir (DTG)-Based Antiretroviral Therapy vs. Standard of Care (SOC) in Children With HIV Infection Starting First-line or Switching to Second-line ART

HIV Infection

United Kingdom, Spain, Portugal, South Africa, Thailand, Uganda, Germany, Zimbabwe
Gilead Sciences

Recruiting

Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1

HIV-1 Infection

United States, Thailand, Uganda, South Africa
GlaxoSmithKline

Completed

To Evaluate Safety, Tolerability, Pharmacokinetics, And Food Effect Of Single Doses Of GSK945237 In Healthy Subjects

Healthy Subjects | Infections, Bacterial

Australia
ViiV Healthcare
GlaxoSmithKline

Completed

Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Portugal, Russian Federation, Mexico, Argentina, South Africa, Puerto Rico
Wellstat Therapeutics

Completed

Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer

Pancreatic Cancer | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
BioMérieux

Completed

Performance Evaluation of the VIDAS TB-IGRA Assay.

Active Tuberculosis | Latent Tuberculosis Infection | Non-Tuberculous Mycobacterial (NTM) Pneumonia

United States, France, United Kingdom, India, Brazil, Georgia, Italy, Mexico, South Africa
The University of Queensland
Griffith University; The Prince Charles Hospital; Princess Alexandra Hospital... and other collaborators

Completed

Reducing Acute Severe Respiratory Events in Health Care Workers During the Covid-19 Pandemic With OM85 (COVIDRASP)

Covid19 | Respiratory Viral Infection

Australia
Leiden University Medical Center

Recruiting

UTI Reference Standard: Delphi Method (ORACLE)

Urinary Tract Infections

Netherlands
GlaxoSmithKline

Completed

A Repeat Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK1322322 in Healthy Subjects

Infections, Bacterial

Australia
State University of New York at Buffalo
United States Agency for International Development (USAID); Save the Children; Unilever R...

Withdrawn

Intervention Study to Improve Maternal Handwashing

Infection | Neonatal

Kenya
GlaxoSmithKline

Completed

Single Dose Escalation First Time in Human PK Study

Infections, Bacterial

Australia
Holdsworth House Medical Practice

Completed

Reducing Cardiovascular Disease (CVD) Risk in HIV on Antiretroviral Therapy Over 12 Months (CVD)

Cardiovascular Disease | HIV-1 Infection

Australia
Aridis Pharmaceuticals, Inc.

Completed

Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301 (AR-301-002)

Staphylococcus Aureus | Pneumonia, Ventilator-Associated | Infection, Bacterial | Lung Infection

Belarus, Belgium, Brazil, China, Estonia, France, Georgia, Israel, Latvia, Mexico, Russian Federation, South Africa, Spain, Turkey, Ukraine
AstraZeneca

Terminated

Melagatran/Ximelagatran Versus Enoxaparin for the Prevention of Venous Thromboembolic Events (EXTEND)

Thromboembolism

Sweden, France, Mexico, Poland, South Africa, Spain, Germany, Hungary, Denmark, Finland, Netherlands, Norway, Austria, Belgium, Portugal, Switzerland
Restem, LLC.

Completed

Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS (ULSC)

Covid19 | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

United States
AstraZeneca
Iqvia Pty Ltd

Completed

Evaluate the Safety and Tolerability, for Nirsevimab in Immunocompromised Children (MUSIC)

RSV Infection

United States, Belgium, Spain, Japan, Poland, South Africa, United Kingdom, Ukraine
Eli Lilly and Company

Active, not recruiting

A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer) (CYCLONE 3)

Urogenital Neoplasms | Prostatic Neoplasms | Neoplasm Metastasis | Enzyme Inhibitors | Antineoplastic Agents | Hormones | Physiological Effects of Drugs | Antineoplastic Agents, Hormonal | Androgens | Hormones, Hormone Substitutes, and Hormone Antagonists | Abiraterone Acetate | Steroid Synthesis Inhibitors | Cytochrome... and other conditions

China, Canada, France, United States, Australia, Czechia, Hungary, Spain, Germany, Japan, Taiwan, Netherlands, Mexico, Belgium, Korea, Republic of, Turkey, Argentina, Romania, United Kingdom, Italy, Israel, Brazil, Poland, Greece
Ural State Medical University
Ural Institute of Cardiology; De Haar Research Foundation

Terminated

Ranibizumab and the Risk of Arterial Thromboembolic Events (RATE)

Coronary Artery Disease | Cerebrovascular Disorders | Age-related Macular Degeneration

Netherlands, Russian Federation
Merck Sharp & Dohme LLC

Recruiting

Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)

HIV | HIV Pre-exposure Prophylaxis

United States, South Africa, Israel
Prisma Health-Upstate
The Cleveland Clinic; Oregon Health and Science University; Penn State University

Completed

Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial) (RINSE)

Ventral Hernia Repair

United States
National Cancer Institute (NCI)
Bill and Melinda Gates Foundation

Enrolling by invitation

Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study (ESCUDDO)

Human Papillomavirus Infection | Human Papillomavirus-Related Cervical Carcinoma

Costa Rica
407 Doctors
Bristol-Myers Squibb; Merck Sharp & Dohme LLC

Unknown

Once Daily 3TC, Efavirenz and ddI for HIV Infection

HIV Infection | AIDS

Australia
MeMed Diagnostics Ltd.

Completed

Establish MeMed BV™ Performance for Differentiating Bacterial From Viral Infection in Suspected Acute Infection Patients (APOLLO STUDY) (Apollo)

Acute Infection

Israel, United States
Zarbee's Inc.
Advanced Clinical Research

Terminated

A Novel Formulation of Pasteurized Maple Cough Syrup Compared With Placebo on Nocturnal Cough and Sleep Quality in Infants With Upper Respiratory Infection

Cough | Upper Respiratory Infection | Nocturnal Cough

United States
Ology Bioservices

Completed

Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801

Prophylaxis of Ross River Virus Infection

Australia
University of North Carolina, Chapel Hill
National Institute on Drug Abuse (NIDA); National Institute on Alcohol Abuse... and other collaborators

Completed

Comparison of Three Hepatitis B Vaccination Regimens in HIV-Positive Youth

HIV Infection | Hepatitis B

Brazil, United States, South Africa
Vaxine Pty Ltd
Central Adelaide Local Health Network Incorporated

Completed

Monovalent Recombinant COVID19 Vaccine (COVAX19)

Coronavirus Infection | COVID

Australia
Hellenic Institute for the Study of Sepsis

Completed

Anti-inflammatory Clarithromycin for Improving COVID-19 Infection Early (ACHIEVE)

Virus Diseases | COVID-19 | Corona Virus Infection

Greece
Vaxine Pty Ltd
Australian Respiratory and Sleep Medicine Institute

Not yet recruiting

A Randomised Controlled Phase 1 Study of Vaccine Therapy for Control or Cure of Chronic Hepatitis B Virus Infection (HBV003)

Chronic Hepatitis b

Australia
ChemoCentryx

Completed

Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis

ANCA-associated Vasculitis

United States, Canada
Erasmus Medical Center
Elisabeth-TweeSteden Ziekenhuis; Rijnstate Hospital; Red Cross Hospital Beverwijk and other collaborators

Recruiting

Suture Techniques to Reduce the Incidence of Incisional Hernia: LTFU STITCH Trial (LTFU-STITCH)

Quality of Life | Pain | Surgery | Wound Infection | Incisional Hernia | Fascial Dehiscence

Netherlands
Janssen-Cilag International NV

Completed

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment (SALIF)

Human Immunodeficiency Virus-type 1 Infection

South Africa, Kenya, Thailand, Uganda, Cameroon, Senegal
The University of Queensland

Recruiting

A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients (BEAT-BK)

Kidney Transplant Infection | Kidney Transplant Failure and Rejection | BK Viremia

Australia
Novartis Pharmaceuticals

Terminated

A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People (APOLLO)

Cardiovascular Events

Colombia, India, South Africa, Canada, Spain, Hungary, United States, Germany, Ireland, Argentina, Philippines, Brazil, Sweden, Malaysia, Chile, Israel, Czech Republic, Netherlands
National Institute of Allergy and Infectious Diseases...
ViiV Healthcare

Suspended

Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals

HIV Infection | LTBI

United States, Haiti, Botswana, Brazil, Thailand, Zimbabwe, Malawi, Peru, South Africa
Ology Bioservices

Completed

Ross River Virus (RRV) Vaccine Study

Prophylaxis of Ross River Virus Infection

Australia

Clinical Trials on Anti-Infective Agents in South Africa

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