Clinical Trials on Beta-thalassemia Major

Total 3338 results

Novartis Pharmaceuticals

Completed

Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload

Myelodysplastic Syndromes | Beta-Thalassemia

Hungary
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

Sickle Cell Disease | Thalassemia | Thalassemia, Beta

United States
Talaris Therapeutics Inc.
Duke University

Withdrawn

Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies

Anemia, Sickle Cell | Thalassemia | Beta-Thalassemia | Bone Marrow Failure Syndromes | Diamond-Blackfan Anemia | Alpha-Thalassemia | Complex and Transfusion-dependent Hemoglobinopathies

United States
University of Thessaly

Completed

Resistance Exercise on Postprandial Hyperglycemia in Patients With B-thalassemia Exhibiting Resistance to Insulin

Diabetes Mellitus, Type 2 | Insulin Resistance | PreDiabetes | Beta-Thalassemia

Greece
Fairview University Medical Center

Completed

Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders

Neutropenia | Sickle Cell Anemia | Red-Cell Aplasia, Pure | Thalassemia Major

United States
Tanta University

Completed

Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C Virus

Hepatitis C | Beta-Thalassemia

Egypt
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety and Effectiveness of Luspatercept for the Treatment of Transfusion-dependent (TD) Anemia Associated With Myelodysplastic Syndromes (MDS) & Beta-thalassemia (β-Thal) in India

Anemia

India
University Health Network, Toronto

Recruiting

Thalassemic Iron Overload Cardiomyopathy is Ameliorated by Taurine Supplementation (TICATS)

Thalassemia Major

Canada
ApoPharma

Completed

Efficacy Study in Removing Excess Iron From the Heart

Hemosiderosis | Thalassemia Major

Greece, Italy
University Health Network, Toronto

Completed

MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias (MAFIO)

Thalassemia Major | Chronic Blood Transfusion Related Iron Overload

Canada
Ospedale Microcitemico
Azienda Sanitaria Locale di Cagliari

Completed

Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major (DFODFPTM)

Iron Overload | Cardiomyopathy

Italy
Ente Ospedaliero Ospedali Galliera

Completed

Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia (PAH2010)

Pulmonary Arterial Hypertension | Thalassemia Major | Thalassemia Intermedia

Italy
Shiraz University of Medical Sciences

Completed

Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia Intermedia

β-Thalassemia Intermedia

Iran, Islamic Republic of
Azienda Ospedaliero-Universitaria di Modena

Recruiting

"Iron Overload and Endocrinological Diseases"

Iron Overload | Hemochromatosis | Thalassemia Major | Thalassemia Intermedia | Endocrinopathy

Italy
Silence Therapeutics plc

Withdrawn

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome

United Kingdom, Bulgaria
Sangamo Therapeutics

Enrolling by invitation

Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.

Blood and Lymphatic Diseases

United States
University Hospital of Ferrara

Recruiting

Atrial Fibrillation in Beta-Thalassemia

Atrial Fibrillation | Thalassemia

Italy
Shenzhen Hemogen

Recruiting

the Safety and Efficacy Evaluation of HGI-001 Injection in Patients With Transfusion-Dependent β-Thalassemia

β-thalassemia

China
Shanghai BDgene Co., Ltd.
Ruijin Hospital

Not yet recruiting

Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent β-thalassemia

β-thalassemia

China
Bristol-Myers Squibb

Recruiting

A Post-Marketing Surveillance Study to Assess Safety of Luspatercept in Korean Patients With Myelodysplastic Syndrome or β-thalassemia

Myelodysplastic Syndrome | Beta Thalassemia

Korea, Republic of
Shanghai BDgene Co., Ltd.
Shanghai Children's Medical Center

Not yet recruiting

Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent Beta-thalassemia

β-thalassemia
Kind Pharmaceuticals LLC

Not yet recruiting

A Study of Safety and Efficiency of AND017 in Patients With Transfusion Dependent and Non-transfusion Dependent β-thalassemia

β -Thalassemia
Shenzhen Hemogen

Recruiting

Safety and Efficacy Evaluation of β-globin Restored Autologous Hematopoietic Stem Cells in β-thalassemia Major Patients

β-thalassemia

China
Protagonist Therapeutics, Inc.

Completed

Safety Study for Beta Thalassemia Subjects on PTG-300 (TRANSCEND)

β-thalassemia | Ineffective Erythropoiesis

Malaysia, Thailand, United States, Greece, United Kingdom, Turkey, Lebanon, Tunisia
Prothya Biosolutions

Terminated

Apotransferrin in Patients With β-thalassemia

β-thalassemia Intermedia

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)
National Institutes of Health Clinical Center (CC); National Cancer Institute...

Recruiting

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Stem Cell Transplantation | Sickle Cell Disease | Thalassemia | Graft vs Host Disease

United States
Assiut University

Completed

Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major Children

Hemolysis | Pulmonary Hypertension | Thalassemia in Children

Egypt
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI); Thalassemia Clinical Research...

Completed

Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)

Hematologic Diseases | Iron Overload | Hypertension, Pulmonary | Osteoporosis | Thalassemia | Beta-Thalassemia | Anemia, Cooley's

United States, Canada
Cairo University

Recruiting

Correlation Between Pulmonary Functions and Physical Fitness in Children With β-thalassemia

Pulmonary Function | Physical Fitness | β-Thalassemia

Egypt
Assiut University

Unknown

Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait .

Microcytic Hypochromic Anemia
Silence Therapeutics plc

Completed

A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome | Very-Low Risk Myelodysplastic Syndrome

Thailand, Israel, Jordan, United Kingdom, Germany, Italy, Malaysia
Protagonist Therapeutics, Inc.

Completed

Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia (TRANSCEND)

Chronic Anemia | β-thalassemia | Ineffective Erythropoiesis

United States, Malaysia, Turkey, Thailand, United Kingdom, Italy, Lebanon, Tunisia, Greece
Assiut University

Not yet recruiting

Thyroid Function , HbA1c in Relation to Ferritin Level in Adullt Patient e B Thalassemia

B Thalassemia
Allife Medical Science and Technology Co., Ltd.

Unknown

iHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

Thalassemia
Boston Children's Hospital
Novartis

Completed

Pilot Study for Patients With Poor Response to Deferasirox

Sickle Cell Disease | Thalassemia Major | Transfusion-dependent Hemachromatosis

United States
Shanghai BDgene Co., Ltd.
920th Hospital of Joint Logistics Support Force of People's Liberation Army...

Recruiting

A Study Evaluating the Safety and Efficacy of the BD211 Drug Product in β-Thalassemia Major Participants

Hematologic Diseases

China
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia Intermedia

Thalassemia

United States, Canada
Mahidol University

Completed

The Change of Coagulation Markers in Children With β-thalassemia Disease After Stem Cell Transplantation

Thalassemia

Thailand
Ain Shams University

Unknown

Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.

Thalassemia Intermedia

Egypt
Assiut University

Not yet recruiting

Assessment of Cognitive Functions, Psychological Symptoms, and Quality of Life Among B Thalassemia Patients and Their Clinical Correlates.

B Thalassemia
Assiut University

Unknown

Quality of Life and Treatment Satisfaction in β-Thalassemia Patients Receiving Deferasirox

β-thalassemia

Egypt
Sherief Abd-Elsalam

Recruiting

L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

Thalassemia

Egypt
University of Milano Bicocca

Completed

Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases (ThalaCoV)

Covid19 | Thalassemia Major

Italy
Hematology department of the 920th hospital

Recruiting

Clinical Observation of Luspatercept in Treatment of Chinese Adult β-thalassaemia Patients With TD β-thalassemia

Effect of Drug

China
Assiut University

Completed

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Thalassemia

Egypt
Columbia University

Completed

High-Tc Susceptometer to Monitor Transfusional Iron Overload

Myelodysplastic Syndromes | Sickle Cell Disease | Aplastic Anemia | Transfusional Iron Overload | Thalassemia Major

United States
Novartis Pharmaceuticals

Completed

Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload | β-thalassemia

Italy
Novartis Pharmaceuticals

Completed

An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload in β-thalassemia

United States, Greece, Argentina, Germany, Belgium, Italy, United Kingdom, France, Tunisia, Canada, Turkey, Brazil
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload

Cardiac Iron Overload | Transfusion-dependent β-thalassemia Patients

Greece
HaEmek Medical Center, Israel

Unknown

A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients.

Thalassemia | Brain Function (Measured by ERP Level)

Israel

Clinical Trials on Beta-thalassemia Major

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