Clinical Trials on Biological Samples in South Africa

Total 218 results

Drexel University
University of North Carolina, Chapel Hill; University of KwaZulu

Completed

MAMAS: Mentoring Adolescent Mothers at School (MAMAS)

Chlamydia | Gonorrhea | Human Immunodeficiency Virus | Trichomonas Vaginitis | Herpes Simplex Type II

South Africa
Centers for Disease Control and Prevention
London School of Hygiene and Tropical Medicine; National Institute for Communicable...

Completed

Episodic Acyclovir Therapy for Genital Ulcers

HIV Infections | Ulcer | Herpes Simplex

South Africa
Bayer

Completed

FREEDOM - First Real-Life Evaluation of Enablex Done in ZA Overactive Bladder Patients During a 3 Months Period (FREEDOM)

Overactive Bladder

South Africa
French National Agency for Research on AIDS and...

Terminated

Effect of Male Circumcision on HIV Incidence (ANRS 1265)

HIV Infections | Herpes Genitalis | Venereal Diseases

South Africa
University of Washington
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes...

Completed

GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women (PK/GUD)

Genital Herpes

South Africa, Zambia
Pelvic Floor Research Foundation of South Africa
University of Cape Town

Unknown

To Evaluate the Use of Bioresorbable Tephaflex™ Sling for Stress Urinary Incontinence (Tephaflex)

Stress Urinary Incontinence

South Africa
BioCryst Pharmaceuticals

Completed

First-in-Human Study of BCX9930 in Healthy Volunteers and Patients With PNH

Paroxysmal Nocturnal Hemoglobinuria

United Kingdom, Austria, South Africa
BioCryst Pharmaceuticals

Recruiting

Dose Escalation of BCX10013 in Subjects With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria

South Africa, Malaysia
BioCryst Pharmaceuticals

Terminated

A Long Term Safety Study of BCX9930 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria | PNH

United Kingdom, Austria, South Africa
Endo Pharmaceuticals
Medical Research Council; Department for International Development, United...

Completed

Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection

HIV Infections | Gonorrhea | Genital Herpes | Chlamydial Infections

South Africa, Tanzania, Uganda, Zambia
University of Washington
Bill and Melinda Gates Foundation

Completed

Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission

HIV Infection | Sexually Transmitted Diseases | Herpes Simplex, Genital

South Africa, Kenya, Botswana, Rwanda, Tanzania, Uganda, Zambia
BioCryst Pharmaceuticals

Terminated

BCX9930 for the Treatment of PNH in Subjects Not Receiving Other Complement Inhibitor Therapy (REDEEM-2)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Malaysia, South Africa, Korea, Republic of
University of Hohenheim
Universidad de Costa Rica

Completed

Bioavailability of Carotenoids Present in Mamey Sapote (Pouteria Sapota (Jacq.) H. E. Moore & Stearn) Fruit

Biological Availability

Costa Rica, Germany
CONRAD
United States Agency for International Development (USAID); Follow-on African...

Completed

Safety and Effectiveness of Tenofovir Gel in the Prevention of Human Immunodeficiency Virus (HIV-1) Infection in Women and the Effects of Tenofovir Gel on the Incidence of Herpes Simplex Virus (HSV-2) Infection

HIV Prevention

South Africa
GlaxoSmithKline

Completed

Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects

Prophylaxis for Herpes Simplex

Austria, Germany, Belgium, United States, Australia, Canada, Denmark, France, Puerto Rico, South Africa, Spain, Switzerland
Wake Forest University Health Sciences
Boston Scientific Corporation

Recruiting

Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy (SASS)

Stress Urinary Incontinence | Pelvic Floor Disorders

United States, South Africa
GlaxoSmithKline

Completed

A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children

Herpes Simplex

United States, Chile, South Africa
Allergan

Completed

Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder

Overactive Bladder

Portugal, South Africa, Netherlands, Canada, Singapore, Brazil, United States, Taiwan, Italy, United Kingdom, France, Spain
National and Kapodistrian University of Athens

Completed

Ureteral Stent Related Lower Urinary Tract Symptoms- A Comparative Study

Ureteral Stent-Related Symptom

Greece
Alcon Research

Completed

Early Feasibility Study of UV-Femtosecond Laser Assisted Lenticular Extraction

Refractive Error - Myopia Severe | Refractive Error - Myopia Simple

United States, Ireland, Singapore
BioCryst Pharmaceuticals

Active, not recruiting

Long-term Safety of BCX9930 in Subjects With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria

United Kingdom, Hungary, France, Spain, Malaysia, South Africa, Korea, Republic of
Beech Tree Labs, Inc.
Norwich Clinical Research Associates Ltd.; Hill Top Research

Completed

Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores

Oral Herpes Simplex

United States
Premier Specialists, Australia

Unknown

Using Topical Sirolimus 2% for Patients With Epidermolysis Bullous Simplex (EBS) Study

Epidermolysis Bullosa Simplex | Epidermolysis Bullosa Simplex Kobner | Weber-Cockayne Syndrome

Australia
University of Sydney

Completed

Herpes Zoster Vaccine for Bone Marrow Transplant Donors (VZV-Zostavax)

Herpes Zoster

Australia
GlaxoSmithKline

Completed

Safety and Immunogenicity of GSK Biologicals' Herpes Zoster Vaccine 1437173A in Healthy Ethnic Japanese Adults

Herpes Zoster

Australia
French National Agency for Research on AIDS and...

Completed

Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)

Ulcer | Herpes Genitalis

Central African Republic, Ghana
Medivir

Completed

Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis

Herpes Labialis

United States
Healthy.io Ltd.

Completed

Evaluation of the Accuracy and Usability of the ACR | U.S. Urine Analysis Test System in the Lay User Hands

Albuminuria

United States
Shenzhen Shenxin Biotechnology Co., Ltd

Not yet recruiting

A Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants

Herpes Zoster

United States, Australia
Eli Lilly and Company
Boehringer Ingelheim

Completed

To Determine How Effective Duloxetine is in Treating Women 65 Years and Older With Symptoms of Stress Urinary Incontinence, or With a Combination of Stress Urinary Incontinence and Urge Urinary Incontinence Symptoms

Urinary Incontinence, Stress

France, Sweden, Netherlands, Spain, Germany, South Africa, Switzerland
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Peripheral Electrical Stimulation for the Treatment of Overactive Bladder (PESTOB)

Idiopathic Overactive Bladder

United Kingdom
GlaxoSmithKline

Completed

The Study To Test The Effect of Standardization Of Fluid Intake In Female Patients With Overactive Bladder

Overactive Bladder

Australia
Premier Specialists, Australia

Active, not recruiting

Pilot Study Assessing the Effect of Tildrakizumab in Vitiligo (TILDVIT-1227)

Skin Diseases | Vitiligo | Hypopigmentation | Skin and Connective Tissue Diseases | Pigmentation Disorder | Biologic

Australia
TWi Biotechnology, Inc.

Recruiting

An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)

Generalized Epidermolysis Bullosa Simplex

United States, Taiwan, Australia, Philippines, Austria, Italy, Poland
ASTORA Women's Health

Terminated

Collection of Long Term Patient Outcomes Data Following Implantation of AMS Surgical Devices (CAPTURE)

Pelvic Organ Prolapse | Female Stress Incontinence

United States, Spain, Slovenia, France, United Kingdom, Canada, Germany, South Africa
Ferring Pharmaceuticals

Completed

Study Investigating the Impact Burden of Nocturia Using the Nocturia Impact Diary (IMPACT)

Nocturia

United States
MedtronicNeuro

Completed

Evaluation of Implantable Tibial Neuromodulation (TITAN 1) Feasibility Study (TITAN 1)

Overactive Bladder

United States
Dynavax Technologies Corporation

Completed

Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adult Volunteers

Herpes Zoster | Vaccine-Preventable Diseases | Shingles

Australia
Alessa Therapeutics Inc.

Completed

A Study to Establish the Feasibility of Biolen for the Local Delivery of Bicalutamide in Patients With Prostate Cancer (Biolen-PC)

Lower Urinary Tract Symptoms | Prostate Adenocarcinoma

United States, Australia, New Zealand
Alabama Physical Therapy & Acupuncture
Universidad Rey Juan Carlos

Terminated

Neuromuscular Re-eduaction, Exercise and Electric Dry Needling vs. Neuromuscular Re-education and Exercise for Stress Urinary Incontinence

Stress Urinary Incontinence

United States
Astellas Pharma Europe B.V.

Completed

A Study to Investigate How Safe and Effective Solifenacin Solution is in Treating Children/Adolescents With Symptoms of Overactive Bladder (OAB) Who Completed Study 905-CL-076 (LEOPARD)

Urinary Bladder, Overactive

Belgium, United States, Brazil, Canada, Denmark, Former Serbia and Montenegro, Korea, Republic of, Mexico, Norway, Philippines, Poland, South Africa, Sweden, Turkey, Ukraine, United Kingdom
Allergan

Completed

A Long-term Follow-up Study of Botulinum Toxin Type A in Patients With Overactive Bladder as a Result of Spinal Injury or Multiple Sclerosis

Overactive Bladder

Poland, United Kingdom, Portugal, South Africa, Ukraine, Australia, Netherlands, Canada, Singapore, Russian Federation, Germany, Brazil, Austria, Slovakia, Czechia, United States, Taiwan, Italy, France, Belgium, Spain, New Zealand
InMode MD Ltd.

Completed

Bi-Polar Radio-Frequency and Electrical Muscle Stimulation for Symptoms of Mixed Urinary Incontinence (MUI)

Urinary Incontinence

United States
Astellas Pharma Europe B.V.

Completed

A Study to Investigate How Effective and Safe Solifenacin Succinate Suspension is in Treating Children/Adolescents Aged 5 to Less Than 18 Years With Symptoms of Overactive Bladder (OAB) Compared to a Non-active Drug (LION)

Urinary Bladder, Overactive

Belgium, United States, Brazil, Canada, Denmark, Former Serbia and Montenegro, Korea, Republic of, Mexico, Norway, Philippines, Poland, South Africa, Sweden, Turkey, Ukraine, United Kingdom
GlaxoSmithKline

Completed

Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine

Herpes Simplex

United States, Belgium, Canada
NanoBio Corporation

Completed

A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis (SHaRCS)

Recurrent Herpes Simplex Labialis

United States
Boehringer Ingelheim

Completed

Actual Use Study of Tamsulosin in Men

Urological Manifestations

United States
Ferring Pharmaceuticals

Completed

Investigation of the Superiority Effect of Desmopressin to Placebo in Terms of Night Voids Reduction in Nocturia Adult Female Patients (COMFORT)

Nocturia

United States, Canada
Ethicon, Inc.

Completed

TVT Worldwide Registry

Stress Urinary Incontinence

Korea, Republic of, United States, Australia, Austria, Canada, Germany, Singapore, South Africa, United Kingdom
Castle Creek Pharmaceuticals, LLC

Terminated

Safety and Efficacy of Diacerein 1% Ointment for Subjects With Epidermolysis Bullosa Simplex (EBS)

Epidermolysis Bullosa Simplex

United States, Israel, Australia, Austria, France, Germany, Netherlands, United Kingdom

Clinical Trials on Biological Samples in South Africa

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