Clinical Trials on Blood Transfusion

Total 94577 results

St Vincent's Hospital, Sydney

Completed

Blood Management During ECMO for Cardiac Support (OBLEX)

Hemorrhage | Embolism | Venous Thrombosis | Arrhythmias, Cardiac | Shock, Cardiogenic | Blood Transfusion | Death, Sudden, Cardiac | Disseminated Intravascular Coagulation | HEART ARREST

Australia
Editas Medicine, Inc.

Not yet recruiting

A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301

Sickle Cell Disease | Hemoglobinopathies | Transfusion-dependent Beta-Thalassemia
Institute of Hematology & Blood Diseases Hospital

Recruiting

Growth and Development-related Outcomes in Children With Transfusion-dependent Beta-thalassemia After Gene Therapy

Gene Therapy | Transfusion-dependent Beta-Thalassemia

China
Novartis Pharmaceuticals

Withdrawn

Deferasirox BID (Twice a Day) in Transfusion Dependent Thalassemia Patients With Inadequate Response to High Doses

Focus on Transfusion Dependent Thalassemia Patients Who Are Inadequate Responders to Deferasirox > 35mg/kgQD
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Cord Blood Transfusion In Preterm Neonates (CB-TrIP) (CB-TrIP)

Premature Infant Disease | Transfusion Related Complication | Fetal Hemoglobin

Italy
Children's Hospital of Chongqing Medical University

Recruiting

Hepatitis B Vaccination After Neonatal Surgery

Hepatitis B Virus Infection | Hepatitis B Vaccine Adverse Reaction | Blood Transfusion Complication | Vaccination Reaction | Digestive System Disorders of Fetus and Newborn

China
University Health Network, Toronto

Completed

MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias (MAFIO)

Thalassemia Major | Chronic Blood Transfusion Related Iron Overload

Canada
University of California, San Francisco

Terminated

Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Myeloid Malignancy | Metabolic Disease | Bone Marrow Failure Syndrome | Transfusion-dependent Red Blood Cell (RBC) Defect | Congenital Immunodeficiency | Severe Immune Dysregulation

United States
Centre Hospitalier Universitaire de Nice

Completed

Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants

Kidney Diseases | Sepsis | Pulmonary Disease | Hypoxic-Ischemic Encephalopathy | Cardiac Disease | Metabolic Disease | Twin to Twin Transfusion Syndrome

France
University of Campania "Luigi Vanvitelli"

Completed

Endocrine Function During Deferasirox Therapy

Iron Overload | Endocrine; Complications | Transfusion-dependent Thalassemia

Italy
Juan Blanco Morillo
Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca

Completed

Haemo-autologous Antegrade Repriming (HAR) as Minimum Impact Perfusion Strategy for Cardiopulmonary Bypass (HARjbm1)

Embolism, Air | Anemia | Cardiac Disease | Valve Anomalies | Extracorporeal Circulation; Complications | Transfusion | Cognitive; Disorder, Due to General Medical Condition

Spain
Novartis Pharmaceuticals

Completed

A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity

Transfusional Iron Overload

United States, Greece, Italy
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndrome and Transfusion-dependent Iron Overload

Myelodysplastic Syndromes | Transfusion Dependent Iron Overload

Germany
Clinica Universidad de Navarra, Universidad de...
Hospital Clinic of Barcelona; Hospital Son Espases; Hospital del Mar; Hospital... and other collaborators

Active, not recruiting

Predictive Model to Calculate the Risk of RBC Transfusion in Elective Brain Tumours Resections (TScoreBTR) (TScoreBTR)

Surgery | Brain Tumor Adult | Transfusion

Spain
Monash University
CSL Behring; National Blood Authority; New Zealand Blood Service; Department of...

Recruiting

Australian and New Zealand Massive Transfusion Registry (ANZ-MTR)

Trauma | Gastrointestinal Bleeding | Liver Transplant | Cardiothoracic Surgery | Vascular Surgery | Massive Transfusion | Obstetric Bleeding

Australia
Regeneron Pharmaceuticals

Not yet recruiting

A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body (FERVENT-1)

Non-transfusion Dependent Beta-thalassemia (NTDT)
Hospital Universitari de Bellvitge

Completed

Implementation of a Patient Blood Management Program in Gastric Cancer Surgery (IPAT)

Gastric Cancer | Surgery--Complications | Anemia, Iron Deficiency | Transfusion Related Complication
Sheba Medical Center
Hadassah Medical Organization; Kaplan Medical Center; Tel Aviv Medical Center; Ziv...

Completed

Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients

Myelodysplastic Syndrome With Low-grade Lesions | Iron Overload Due to Repeated Red Blood Cell Transfusions

Israel
Goztepe Prof Dr Suleyman Yalcın City Hospital

Active, not recruiting

Warmed Blood Transfusion in Premature Infants

Premature | Transfusion Related Complication

Turkey
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrovirus Epidemiology Donor Study I (REDS I)

HIV Infections | Acquired Immunodeficiency Syndrome | Retroviridae Infections | Blood Transfusion | HIV-1 | Blood Donors | HIV-2 | HTLV-I | HTLV-II
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Viral Activation Transfusion Study (VATS)

HIV Infections | Acquired Immunodeficiency Syndrome | Cytomegalovirus Infections | Blood Transfusion
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload

Cardiac Iron Overload | Transfusion-dependent β-thalassemia Patients

Greece
Instituto de Investigación Hospital Universitario...

Completed

Complications Associated With Intraoperative Hypothermia.

Hypothermia | Hemorrhage, Postpartum | Transfusion-dependent Anemia | Infection Surgical Wound

Spain
Silence Therapeutics plc

Withdrawn

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome

United Kingdom, Bulgaria
Novartis Pharmaceuticals

Terminated

Myelodysplastic Syndrome (MDS) Gastrointestinal (GI) Tolerability Study (MACS1574)

Myelodysplastic Syndrome | Transfusional Iron Overload

Spain, France, Italy, South Africa
Xiaoping Fan. MD
Jie He.MD; Shihao Cai.MD; Wenda Gu.PhD; Haijiang Guo.PhD; Liang Hong. MD; Ruixing Fan... and other collaborators

Unknown

A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.

Aneurysm | Blood Transfusion | Dialysis | Neurological Disorder | Morality | Endoleak | Operation Time | Hospital Stay | Hypothermic Circulatory Arrest Time | Aortic-cross Clamping Time | Cardiopulmonary Bypass Time | Re-Thoracotomy | ICU Stay | Mechanical Ventilation Time

China
Mansoura University Children Hospital

Completed

Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency

Preterm Infant | Placental Transfusion | Placental Insufficiency

Egypt
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Patients With Chronic Anemia and Transfusional Hemosiderosis

Transfusional Hemosiderosis | Chronic Anemia

Japan, Turkey, Spain, Poland, Singapore
Sunnybrook Health Sciences Centre
Ontario Ministry of Health and Long Term Care; Sault Area Hospital; Scarborough... and other collaborators

Completed

Ontario ICU Clinical Best Practices Demonstration Project

Catheter Related Blood Stream Infections | Ventilator Acquired Pneumonia | Pressure Ulcer Prophylaxis | DVT Prophylaxis | Restrictive Blood Transfusion Strategy | Daily Spontaeous Breathing Trials

Canada
Children's Hospital Los Angeles
Novartis Pharmaceuticals

Terminated

Clinical Importance of Treating Iron Overload in Sickle Cell Disease

Anemia, Sickle Cell | Transfusion Hemosiderosis

United States
Weill Medical College of Cornell University

Completed

Delayed Cord Clamping in Preterm Neonates (DCC)

Premature Birth of Newborn | Infant, Very Low Birth Weight | Placental Transfusion | Delayed Separation of Umbilical Cord

United States
Silence Therapeutics plc

Completed

A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome | Very-Low Risk Myelodysplastic Syndrome

Thailand, Israel, Jordan, United Kingdom, Germany, Italy, Malaysia
The University of Texas Health Science Center at...
National Heart, Lung, and Blood Institute (NHLBI)

Completed

KSHV Infection in Blood Donors From Texas

HIV Infections | Acquired Immunodeficiency Syndrome | Sarcoma, Kaposi | Blood Transfusion | Blood Donors | Herpesvirus, Kaposi Sarcoma-Associated
Boston Children's Hospital
Novartis

Completed

Pilot Study for Patients With Poor Response to Deferasirox

Sickle Cell Disease | Thalassemia Major | Transfusion-dependent Hemachromatosis

United States
Shire

Terminated

Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron Overload

Beta-Thalassemia | Transfusional Iron Overload

United States, Lebanon, Canada, Italy, Turkey
Shire

Completed

Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, United Kingdom, Italy, Thailand, Turkey
FerroKin BioSciences, Inc.

Completed

Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, Australia, Thailand
Novartis Pharmaceuticals

Completed

An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload in β-thalassemia

United States, Greece, Argentina, Germany, Belgium, Italy, United Kingdom, France, Tunisia, Canada, Turkey, Brazil
Novartis Pharmaceuticals

Completed

Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload | β-thalassemia

Italy
Bloodworks
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Prospective Study of HIV Infection in Hemophiliacs

HIV Infections | Acquired Immunodeficiency Syndrome | Hemophilia A | Hepatitis, Viral, Human | Blood Disease | Cytomegalovirus Infections | Blood Transfusion
Children's Hospital of Philadelphia
Ann & Robert H Lurie Children's Hospital of Chicago; The Cooley's Anemia Foundation...

Completed

Combination Deferasirox and Deferiprone for Severe Iron Overload in Thalassemia

Thalassemia Major With Severe Transfusional Iron Overload

United States
Medical College of Wisconsin
National Heart, Lung, and Blood Institute (NHLBI); University of Wisconsin,... and other collaborators

Recruiting

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Sudden Infant Death | Congenital Heart Disease | Pregnancy Loss | Gastroschisis | Fetal Death | Brugada Syndrome | High Risk Pregnancy | Stillbirth | Long QT Syndrome | Fetal Demise | Birth Defect | Twin Monochorionic Monoamniotic Placenta | Twin Twin Transfusion Syndrome | Fetal Hydrops | Fetal Arrhythmia | Intrauterine... and other conditions

United States
Novartis Pharmaceuticals

Completed

A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.

Transfusional Iron Overload | β-thalassemia Major | Pediatric Rare Anemia

Italy, France
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrovirus Epidemiology Donor Study-II (REDS-II)

HIV Infections | Acquired Immunodeficiency Syndrome | Retroviridae Infections | Hepatitis B | Hepatitis, Viral, Human | Blood Transfusion | HIV-1 | Blood Donors | Hepacivirus | HIV-2 | HTLV-I | HTLV-II | West Nile Virus
Novartis Pharmaceuticals

Completed

Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox

Transfusional Hemosiderosis

Egypt, Spain, United Kingdom, Jordan
Novartis Pharmaceuticals

Completed

Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food

Transfusional Hemosiderosis

United States
Talaris Therapeutics Inc.
Duke University

Withdrawn

Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies

Anemia, Sickle Cell | Thalassemia | Beta-Thalassemia | Bone Marrow Failure Syndromes | Diamond-Blackfan Anemia | Alpha-Thalassemia | Complex and Transfusion-dependent Hemoglobinopathies

United States
Columbia University

Completed

High-Tc Susceptometer to Monitor Transfusional Iron Overload

Myelodysplastic Syndromes | Sickle Cell Disease | Aplastic Anemia | Transfusional Iron Overload | Thalassemia Major

United States
Novartis Pharmaceuticals

Completed

An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study)

Thalassemia, Non-transfusional-dependent Thalassemia (NTDT), Myeloplastic Dysplasia (MDS), Other Anemia

Australia
Masonic Cancer Center, University of Minnesota

Recruiting

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Sickle Cell Disease | Severe Congenital Neutropenia | Paroxysmal Nocturnal Hemoglobinuria | Glanzmann Thrombasthenia | Shwachman-Diamond Syndrome | Diamond Blackfan Anemia | Transfusion Dependent Alpha- or Beta- Thalassemia | Non-Malignant Hematologic Disorders

United States

Clinical Trials on Blood Transfusion

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