Clinical Trials on Bone Marrow Failure Syndromes

Total 10201 results

National Heart, Lung, and Blood Institute (NHLBI)

Completed

Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment

Anemia, Aplastic | Anemia, Hypoplastic

United States
Federico II University

Unknown

Alemtuzumab and Low-Dose Cyclosporine in Treating Patients With Severe Aplastic Anemia or Acquired Marrow Failure

Nonmalignant Neoplasm

Italy
National Taiwan University Hospital

Recruiting

Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Aplastic Anemia | Myeloproliferative Neoplasm

Taiwan
Cellphire Therapeutics, Inc.
Department of Health and Human Services

Completed

Thrombosomes® in Bleeding Thrombocytopenic Patients

Hematologic Diseases | Thrombocytopenia | Bone Marrow Aplasia

United States, Norway
National Heart, Lung, and Blood Institute (NHLBI)

Completed

T-Cell Depletion in Unrelated Donor Marrow Transplantation

Myelodysplastic Syndromes | Leukemia | Bone Marrow Transplantation | Graft vs Host Disease | Immunologic Diseases
Centre Leon Berard

Recruiting

Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Transplantation (EVAADE)

Myelodysplastic Syndromes | Severe Combined Immunodeficiency | Acute Leukemia | Haematological Malignancy | Hemoglobinopathy in Children | Bone Marrow Aplasia

France
Peking University People's Hospital

Recruiting

The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA

Severe Aplastic Anemia

China
Institute of Hematology & Blood Diseases Hospital

Recruiting

Efficacy of Daratumumab to Overcome Platelet Transfusion Refractoriness in Patients With Aplastic Anemia

Aplastic Anemia | Platelet Transfusion Refractoriness

China
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Recruiting

A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) (TransIT)

Severe Aplastic Anemia

United States
Federal Research Institute of Pediatric Hematology...

Recruiting

Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA

Acquired Aplastic Anemia

Russian Federation
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Bioequivalence Study of Hetrombopag in Healthy Subjects

Sever Aplastic Anaemia

China
Shanghai General Hospital, Shanghai Jiao Tong University...
Ruijin Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine and other collaborators

Completed

The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Severe Aplastic Anemia

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Trial of Hetrombopag in Healthy and Hepatic Impairment Subjects

Sever Aplastic Anaemia

China
Fred Hutchinson Cancer Center
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow Transplant

Aplastic Anemia

United States
Nagoya University

Unknown

Randomised Study Comparing Different Dosages of Rabbit ATG in Patients With SAA

Acquired Aplastic Anemia.

Japan
King Faisal Specialist Hospital & Research Center

Completed

Prospective Phase II Study of Rabbit Antithymocyte Globulin (ATG, Thymoglobuline®, Genzyme) With Ciclosporin for Patients With Acquired Aplastic Anaemia

Acquired Aplastic Anaemia
Navy General Hospital, Beijing
Peking Union Medical College Hospital; Cancer Institute and Hospital, Chinese... and other collaborators

Unknown

Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

China
Wake Forest University Health Sciences

Terminated

T-cell Depleted Alternative Donor Transplantation

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Immune Deficiency | Lymphomas | Bone Marrow Failure | Osteopetrosis | Hemoglobinopathy

United States
Peking Union Medical College Hospital

Not yet recruiting

A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA

Drug Effect | Aplastic Anemia

China
Peking Union Medical College Hospital

Not yet recruiting

Avatrombopag Usage in NSAA

Drug Effect | Aplastic Anemia

China
National Institute of Environmental Health Sciences...

Completed

Protection Against Benzene Toxicity

Leukemia | Aplastic Anemia

United States
Hematology department of the 920th hospital

Recruiting

Clinical Study on Modified Allogeneic Hematopoietic Stem Cell Transplantation Regimen for Severe Aplastic Anemia

Severe Aplastic Anemia

China
Anhui Provincial Hospital

Recruiting

Conditioning Regimen Containing Low Dose ATG for The Treatment of Acquired SAA Receiving sUCBT

Severe Aplastic Anemia

China
Northside Hospital, Inc.

Recruiting

Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

United States
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia

Severe Aplastic Anemia

China
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

Severe Aplastic Anemia

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Study to Evaluate the Safety and Efficacy of Hetrombopag Olamine in Severe Aplastic Anemia （SAA） Patient

Severe Aplastic Anemia

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Trial of Hetrombopag in Healthy Subjects

Sever Aplastic Anaemia

China
National Institute of Blood and Marrow Transplant...

Unknown

A Novel TBI Free Conditioning Protocol for Haploidentical Transplant in Acquired Aplastic Anemia: (FluCAB-Prime)

Aplastic Anemia Idiopathic

Pakistan
Assiut University

Unknown

Peripheral Blood Allogenic Stem Cell Transplantation Using Non-anti Thymocyte Globulin Regimens in Severe Aplastic Anemia Patients

Severe Aplastic Anemia
Guangzhou General Hospital of Guangzhou Military...
First Affiliated Hospital, Sun Yat-Sen University; Guangzhou First People's... and other collaborators

Unknown

Mesenchymal Stem Cells Co-transplantation in Alternative Donor Transplantation of Severe Aplastic Anemia.

Severe Aplastic Anemia

China
City of Hope Medical Center

Withdrawn

Reduced-Intensity Preparative Regimen for Allogeneic Stem Cell Transplantation in Patients With Severe Aplastic Anemia

Severe Aplastic Anemia
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia

Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Alemtuzumab to Treat Severe Aplastic Anemia

Severe Aplastic Anemia, Refractory | Severe Aplastic Anemia, Relapse

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Recruiting

Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)

Congenital Amegakaryocytic Thrombocytopenia | Paroxysmal Nocturnal Hemoglobinuria | Shwachman-Diamond Syndrome | Bone Marrow Failure Syndrome | Congenital Pure Red Cell Aplasia | Hereditary Sideroblastic Anemia | Hematologic Neoplasm With Germline GATA2 Mutation | Hematologic Neoplasm With Germline... and other conditions

United States
University of Alabama at Birmingham

Completed

Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis

Lymphoma | Leukemia | Myelofibrosis | Myelodysplastic Syndrome | Severe Aplastic Anemia | Allogeneic Transplant

United States
Benjamin Tomlinson

Recruiting

5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Myelodysplastic Syndromes | MDS/MPN Crossover Syndromes

United States
Institute of Hematology & Blood Diseases Hospital

Unknown

Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)

Urination Disorders | Thrombosis | Proteinuria | Anemia, Hemolytic | Hemoglobinuria, Paroxysmal | Hemoglobinuria | Paroxysmal Nocturnal Hemoglobinuria | Bone Marrow Failure | Aplastic Anemia,

China
Foresee Pharmaceuticals Co., Ltd.

Recruiting

A Dose Escalation Study of FP-045 in Patients With Fanconi Anemia

Fanconi Anemia

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Observational Follow-up Study of Haplo-identical Transplants in Fanconi Disease (HAPLO-FANCONI)

Fanconi Syndrome
Porteus, Matthew, MD

Recruiting

Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab

Fanconi Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Eltrombopag for People With Fanconi Anemia

Fanconi Anemia

United States
Sanguine Biosciences

Terminated

Whole Blood Biospecimen Collection for Subjects With Fanconi Anemia

Fanconi Anemia

United States
Children's Hospital Medical Center, Cincinnati
Food and Drug Administration (FDA)

Completed

Quercetin in Children With Fanconi Anemia; a Pilot Study

Fanconi Anemia

United States
Julian Sevilla

Completed

Eltrombopag for Treatment of Fanconi Anemia

Fanconi Anemia

Spain
Fred Hutchinson Cancer Center
National Heart, Lung, and Blood Institute (NHLBI); Rocket Pharma Limited

Active, not recruiting

Gene Therapy for Fanconi Anemia

Fanconi Anemia

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Completed

Tissue Sample Collection From Patients With Fanconi Anemia

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Fanconi Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Medical Treatment for Diamond Blackfan Anemia

Hematologic Disease | Fanconi's Anemia

United States
Centre Leon Berard

Withdrawn

A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts (EVAADE)

Myelodysplastic Syndromes | Severe Combined Immunodeficiency | Acute Leukemia | Haematological Malignancy | Hemoglobinopathy in Children | Bone Marrow Aplasia

France
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclosporin in the Treatment of Primary Treatment of Non-severe Aplastic Anemia

Non-severe Aplastic Anemia

China

Clinical Trials on Bone Marrow Failure Syndromes

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