Clinical Trials on Cell Transformation, Neoplastic

Total 35991 results

National Cancer Institute (NCI)

Active, not recruiting

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Melanoma | Stage IIIC Cutaneous Melanoma AJCC v7 | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
National Cancer Institute (NCI)

Withdrawn

Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial

Urothelial Carcinoma | Renal Pelvis and Ureter Urothelial Carcinoma | Bladder Carcinoma | Stage III Bladder Cancer AJCC v8 | Stage IVA Bladder Cancer AJCC v8 | Bladder Urothelial Carcinoma | Muscle Invasive Bladder Carcinoma | Stage II Bladder Cancer AJCC v8

Canada
Mandos LLC

Terminated

Niemann-Pick Type C Treatment With Adrabetadex for Symptoms of Brain and Nervous System

Niemann-Pick Type C Disease

United States
University of Aarhus
Aarhus University Hospital

Completed

Early Detection of Epstein-Barr Virus Related Disease.

Epstein-Barr Virus Infections | Post-transplant Lymphoproliferative Disorder | Hemophagocytic Lymphohistiocytoses | Epstein-Barr Virus-Related Hodgkin Lymphoma | Epstein-Barr Virus-Related Non-Hodgkin Lymphoma | Mononucleosis | Epstein-Barr Virus Related Malignancy | Epstein-Barr Viraemia | Hemophag...

Denmark
Astellas Pharma Inc
Vical

Completed

Cytomegalovirus (CMV) Vaccine in Donors and Recipients Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)

Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia

United States
University of Miami
Cigna Foundation

Completed

Research in Ethno-Medicine and Education (REMED) (REMED)

Cervical Cancer | HPV | Human Papillomavirus Infection | Human Papilloma Virus

United States
Gradalis, Inc.

Terminated

A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide (VITA)

Sarcoma | Neoplasms | Neoplasms, Connective and Soft Tissue | Neoplasms by Histologic Type | Sarcoma, Ewing | Neoplasms, Bone Tissue | Neoplasms, Connective Tissue | Ewing Sarcoma | Rare Diseases | Ewing's Tumor Metastatic | Ewing Family of Tumors | Ewing's Sarcoma Metastatic | Ewing's Tumor Recurrent

United States
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Farber Disease (BioFarber) (BioFarber)

Splenomegaly | Hepatomegaly | Ceramidase Deficiency | Farber's Lipogranulomatosis

Germany, India, Egypt
Sanofi

Approved for marketing

Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase Deficiency (ASMD)

Sphingomyelin Lipidosis
National Cancer Institute (NCI)

Active, not recruiting

Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Metastatic Malignant Solid Neoplasm | Stage IIIC Cutaneous Melanoma AJCC v7 | Unresectable Solid Neoplasm | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma... and other conditions

United States
Genzyme, a Sanofi Company

Completed

Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency (ASCEND-Peds)

Sphingomyelin Lipidosis

Brazil, France, Italy, United States, Germany, United Kingdom
National Cancer Institute (NCI)

Completed

Avelumab for People With Recurrent Respiratory Papillomatosis

Human Papilloma Virus | Recurrent Respiratory Papillomatosis | Laryngeal Papilloma, Recurrent | Respiratory Papillomatosis | Juvenile Laryngeal Papilloma

United States
Eric W. Sargent, MD
Med-El Corporation

Withdrawn

Maintaining Cochlear Patency After VIIIth Nerve Surgery

Acoustic Neuroma | Labyrinthitis Ossificans | Profound Hearing Impairment

United States
medac GmbH
Syneos Health; Celerion

Completed

Treosulfan-based Conditioning in Paediatric Patients With Haematological Malignancies

Myelodysplastic Syndromes (MDS) | Acute Lymphoblastic Leukaemias (ALL) | Acute Myeloid Leukaemias (AML) | Juvenile Myelomonocytic Leukaemias (JMML)

Germany, United Kingdom, Italy, Austria, Czechia, Poland
Medical Enterprises Ltd.

Terminated

Mitomycin C Intravesical Chemotherapy in Conjunction With Synergo® Radiofrequency-Induced Hyperthermia for Treatment of Carcinoma in Situ Non-Muscle Invasive Bladder Cancer Patients Unresponsive to Bacillus Calmette-Guérin, With or Without Papillary Tumors. (RITE-USA)

Urinary Bladder Cancer | Bladder Cancer | Malignant Tumor of Urinary Bladder | Bladder Neoplasm | Cancer of Bladder | Carcinoma in Situ of Bladder | Bladder Tumors | Cancer of the Bladder | Neoplasms, Bladder | Papillary Carcinoma of Bladder (Diagnosis) | BCG-Unresponsive Bladder Cancer

United States
Enzyvant Therapeutics GmBH

Completed

Farber Disease Natural History Study

Farber Disease | Farber's Disease | Farber Lipogranulomatosis | Acid Ceramidase Deficiency | Ceramidase Deficiency | N-Laurylsphingosine Deacylase Deficiency | ASAH1 Mutation

United States, Egypt, Canada, Italy, Turkey, Argentina, Germany, India, Sweden
University of Southern California
National Cancer Institute (NCI); National Institute for Biomedical Imaging...

Terminated

Ultrasound and Biomarker Tests in Predicting Cancer Aggressiveness in Tissue Samples of Patients With Bladder Cancer

Stage II Bladder Urothelial Carcinoma | Stage IV Bladder Urothelial Carcinoma | Stage III Bladder Urothelial Carcinoma | Bladder Papillary Urothelial Carcinoma | Stage 0a Bladder Urothelial Carcinoma | Stage 0is Bladder Urothelial Carcinoma | Stage I Bladder Cancer With Carcinoma In Situ | Stage...

United States
Assistance Publique Hopitaux De Marseille

Unknown

Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery (SPEED)

Brain Metastases | Vestibular Schwannoma | Para-optic Meningioma

France
Hospital Israelita Albert Einstein

Terminated

Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxis (CICLODECH)

Chronic Myelomonocytic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Acute Lymphoid Leukemia | Myeloproliferative Disease

Brazil
National Cancer Institute (NCI)

Completed

Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine

Recurrent Thyroid Gland Carcinoma | Stage I Thyroid Gland Papillary Carcinoma | Stage II Thyroid Gland Papillary Carcinoma | Stage III Thyroid Gland Papillary Carcinoma | Stage IV Thyroid Gland Papillary Carcinoma

United States, Canada
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II

Anemia, Sickle Cell | Blood Disease | Chlamydia Infections | Cerebrovascular Accident
University Health Network, Toronto

Completed

Hippocampal Radiation Exposure and Memory

Trigeminal Neuralgia | Schwannoma | Arteriovenous Malformation

Canada
Benovus Bio, Inc.

Unknown

Phase I Study of an Oncofetal Antigen Multi-Peptide Immunotherapy in Subjects With Hematologic Cancer (BBMPI03)

Myelodysplastic Syndrome (MDS) | Acute Myelogenous Leukemia (AML) | Multiple Myeloma (MM) | Smoldering Multiple Myeloma (sMM)

United States
Memorial Sloan Kettering Cancer Center

Completed

Understanding Patient Perspectives on the Risks of Ionizing Radiation Used for Medical Imaging

Breast Cancer | Lung Cancer | Colon Cancer | Neuroblastoma | Testicular Cancer

United States
National Cancer Institute (NCI)

Completed

Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma

Ewing Sarcoma of Bone | Peripheral Primitive Neuroectodermal Tumor | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Extraosseous Ewing Sarcoma

United States
Stanford University
National Cancer Institute (NCI)

Withdrawn

Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting

Osteosarcoma | Ewing Sarcoma | Childhood Acute Lymphoblastic Leukemia | Vomiting in Infants and/or Children | Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies

United States
Actelion

Completed

Miglustat in Niemann-Pick Type C Disease

Niemann-Pick Type C Disease

United States
Memorial Sloan Kettering Cancer Center

Completed

Prevalence+Significance of Paraneoplastic Autoantibodies in Many Cancers

Breast Cancer | Ovarian Cancer | Lung Cancer | Neuroblastoma | Hodgkin's Disease

United States
National Institute of Allergy and Infectious Diseases...
National Cancer Institute (NCI)

Completed

A Study of Patients With AIDS Syndrome

HIV Infections | Lymphoma, Non-Hodgkin | Lymphoma, AIDS-Related | Sarcoma, Kaposi

United States
Centre Hospitalier Universitaire, Amiens
University Hospital, Rouen

Recruiting

Evaluation of the Effectiveness of Virtual Reality Self-rehabilitation in the Treatment of Facial Paralysis and Synkinesis (RéMiFaSy)

Rehabilitation | Virtual Reality | Peripheral Facial Palsy

France
Rebecka Ohm

Recruiting

Neurotomy to Treat Synkinesis Following Peripheral Facial Palsy

Facial Palsy | Bell Palsy | Facial Paralysis | Synkinesis | Peripheral Facial Palsy | Peripheral Facial Paralysis

Sweden
Assistance Publique Hopitaux De Marseille

Unknown

Validation of a French-language Version of Quality of Life Questionnaires in Patients With Peripheral Facial Palsy (PFQDV)

Quality of Life | Peripheral Facial Paralysis

France
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Unknown

Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS)

Mesenchymal Stem Cells | Sjogren's Syndrome

China
The Hospital for Sick Children
The Physicians' Services Incorporated Foundation

Terminated

Electrical Stimulation to Improve Recovery After Peripheral Nerve Injury

Bell Palsy | Hemifacial Paralysis

Canada
Centre Hospitalier Universitaire de Besancon

Unknown

Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children (LYMEPED)

Lyme Disease

France
Stanford University

Completed

Allogeneic Transplantation From Related Haploidentical Donors

Leukemia | MDS | NHL | Graft Versus Host Disease | Blood Cancer | Malignancy | CLL | Hodgkin's Disease

United States
Hacettepe University

Completed

The Struggle That Is Phenylketonuria : What Do The Patients and Caregivers Suffer From

Caregiver Burden | Life Stress | Psychological Well-Being

Turkey
Tel-Aviv Sourasky Medical Center

Completed

The Incidence of Postoperative Re-stratification for Recurrence in Well-differentiated Thyroid Cancer - A Single Tertiary Israeli Center Experience

Papillary Thyroid Cancer | Well Differentiated Thyroid Carcinoma
Atara Biotherapeutics

No longer available

Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies

Lymphoproliferative Disorders | Stem Cell Transplant Complications | Epstein-Barr Virus (EBV) Infections | EBV+ Associated Lymphoma | EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD) | Epstein-Barr Viremia | Lymphoma, AIDS-related | Epstein-Barr Virus-associated Lymphoproliferative... and other conditions
OHSU Knight Cancer Institute
Novartis Pharmaceuticals; Oregon Health and Science University

Completed

Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue Sarcoma

Sarcoma | Recurrent Adult Soft Tissue Sarcoma | Adult Rhabdomyosarcoma | Adult Alveolar Soft Part Sarcoma | Adult Angiosarcoma | Adult Desmoplastic Small Round Cell Tumor | Adult Epithelioid Hemangioendothelioma | Adult Epithelioid Sarcoma | Adult Extraskeletal Myxoid Chondrosarcoma | Adult Extraskeletal... and other conditions

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Terminated

Yoga Therapy in Treating Patients With Malignant Brain Tumors

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Oligodendroglioma | Adult Pineal Gland Astrocytoma | Recurrent Adult... and other conditions

United States
Ohio State University Comprehensive Cancer Center
American Cancer Society, Inc.; Lance Armstrong Foundation

Completed

Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors (FOCUS)

Depression | Pain | Leukemia | Fatigue | Multiple Myeloma | Insomnia | Pancreatic Cancer | Esophageal Cancer | Lung Cancer | Glioblastoma Multiforme | Sleep Disorders | Uncertainty | Ovarian Neoplasm | Anxiety Disorder | Psychological Intervention | Relapsed Lymphoma | Worry | Cognitive-behavioral Therapy | Stage III or IV Cervical... and other conditions

United States
IRCCS San Raffaele
Università Vita-Salute San Raffaele

Recruiting

Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells (SoMuKT)

Carcinoma, Renal Cell | Von Hippel-Lindau Disease

Italy
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Not yet recruiting

HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies (HEM-iSMART C)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
DEKA Biosciences

Recruiting

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

Kidney Cancer | Cancer | Head and Neck Cancer | Gynecologic Cancer | Colorectal Cancer | Solid Tumor | Non Small Cell Lung Cancer | Skin Cancer | Pancreas Cancer

United States
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Recruiting

HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies (HEM-iSMART D)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
Adaptimmune

Recruiting

SPEARHEAD-3 Pediatric Study

Osteosarcoma | Neuroblastoma | Synovial Sarcoma | Malignant Peripheral Nerve Sheath Tumor (MPNST)

United States
Hospices Civils de Lyon

Recruiting

Control Cohort CTRL COH (CTRL COH)

Parkinson's Disease; Amyotrophic Lateral Sclerosis; Glioblastoma; Cancer Without Neurological Disease; Rheumatoid Polyarthritis

France
Emory University
National Cancer Institute (NCI); NovoCure Ltd.

Recruiting

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases

Metastatic Melanoma | Melanoma of Unknown Primary | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Mucosal Melanoma | Metastatic Ocular Melanoma

United States
University Hospital, Brest

Recruiting

Polymyalgia Rheumatica Associated to Primary Sjogren Syndrome (PASS)

Polymyalgia Rheumatica | Sjogren's Syndrome

France

Clinical Trials on Cell Transformation, Neoplastic

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