Clinical Trials on Chemical and Drug Induced Liver Injury, Chronic

Total 11686 results

University of Bergen
Norwegian University of Science and Technology; The Research Council of Norway and other collaborators

Recruiting

TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda (TREAT C-AUD)

Alcohol Drinking | Alcohol Dependence | Alcoholism | Child Abuse | Alcohol Use Disorder | Child, Only | Child Mental Disorder | Alcohol Abuse | Child Neglect | Child Malnutrition

Uganda
Fundacion SEIMC-GESIDA
Janssen-Cilag, S.A.

Completed

A Clinical Trial to Evaluate the Reversibility of Abacavir/Lamivudine/Dolutegravir CNS-Related Neurotoxicity After Switching to Tenofovir/Alafenamide/Emtricitabine/Darunavir/Cobicistat (TAF/FTC/DRV/c) (DETOX)

HIV Infections

Spain
Oslo University Hospital

Recruiting

Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer (SECAIII)

Colorectal Cancer | Liver Metastases

Norway
Universitair Ziekenhuis Brussel
Janssen, LP

Completed

Phase I:Decitabine by Hepatic Arterial Infusion(HAI) in Unresectable Liver Metastases Colorectal Cancer (CRC) (DECIT)

Colorectal Cancer | Liver Metastasis

Belgium
Kyoto University

Unknown

Feasibility Study of Neoadjuvant Chemotherapy Modified FOLFOX6 for Resectable Liver Metastases of Colorectal Cancers

Colorectal Cancer | Liver Metastasis

Japan
Oncorus, Inc.
Merck Sharp & Dohme LLC

Terminated

Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors or With Liver Metastases of Solid Tumors

Melanoma | Cancer | Breast Cancer | Solid Tumor | Squamous Cell Carcinoma of Head and Neck | Triple Negative Breast Cancer | Advanced Solid Tumor | Liver Metastases | Colorectal Carcinoma | Non-melanoma Skin Cancer

United States, Canada
Sun Yat-sen University

Recruiting

Neoadjuvant Serplulimab & Bevacizumab With FOLFOX vs. FOLFOX Alone in RAS/BRAF WT, pMMR/MSS CRC Patients

Colorectal Cancer | Liver Metastases

China
Claus Lindbjerg Andersen
Karolinska Institutet; Medical University of Graz; University of Aarhus; Universitätsklinikum... and other collaborators

Recruiting

Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer

Colorectal Cancer Stage III | Liver Metastasis Colon Cancer

Germany, Denmark, Austria, France, Sweden
Dutch Colorectal Cancer Group

Recruiting

Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases (CAIRO5)

Colorectal Cancer | Liver Metastases

Netherlands, Belgium
Oslo University Hospital

Recruiting

Liver Transplantation and Colorectal Cancer

Colorectal Cancer | Liver Metastasis

Norway
Yonsei University

Completed

Perioperative vs Postoperative Chemotherapy + Bevacizumab in Colorectal Cancer, Liver Mets

Colorectal Cancer | Liver Metastasis

Korea, Republic of
Fudan University

Unknown

Study of Cetuximab in Combination With mFOLFOX-6 (Oxaliplatin, Leucovorin, 5-FU) to Treat Colorectal Liver Metastatic Cancer Patients (CLIME)

Colorectal Cancer | Liver Metastases

China
Kamada, Ltd.

Completed

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Emphysema

United Kingdom, Canada, Denmark, Germany, Ireland, Netherlands, Sweden
National Institute on Alcohol Abuse and Alcoholism...

Completed

Brain Inflammation and Function in Alcoholism

Alcohol Use Disorder (AUD)

United States
University of Sydney
Monash University; Sydney Local Health District

Recruiting

MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder (MPATHY)

Alcohol Dependence | PTSD | Alcohol Use Disorder | Post-traumatic Stress Disorder | Comorbidities and Coexisting Conditions

Australia
Jens Rikardt Andersen
Augustinus Fonden; Københavns Universitet; Familien Hede Nielsens Fond

Withdrawn

The Effect of Cannabis in Pancreatic Cancer

Mortality | Cannabis | Cachexia; Cancer | Morbidity | Neoplasms Pancreatic | Palliative Medicine | Appetite Loss

Denmark
Maastricht University Medical Center
Funding: Stichting Internationaal Parkinson Fonds, The Netherlands

Completed

Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes

Parkinson's Disease | Supranuclear Palsy, Progressive | Multiple System Atrophy | Essential Tremor | Vascular Parkinsonism | Parkinsonian Syndrome | Drug Induced Parkinsonism

Netherlands
University of Colorado, Denver
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

Attention Deficit Hyperactivity Disorder | Alcohol Use Disorder

United States
RAND
National Institute of Mental Health (NIMH); University of Pittsburgh; Boston... and other collaborators

Active, not recruiting

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses (CLARO)

Depression | Addiction | Opioid-use Disorder | Post-traumatic Stress Disorder

United States
University of Washington
National Institute on Drug Abuse (NIDA)

Active, not recruiting

The Community Youth Development Study: A Test of Communities That Care (CYDS IV)

Depression | Anxiety | Suicide | Sexual Behavior | Substance Abuse | Violence | Criminal Behavior | Juvenile Delinquency | Sexually Transmitted Infection | Educational Attainment

United States
Columbia University
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of Alabama... and other collaborators

Terminated

Zambia Common Elements Treatment Approach Pilot Study (ZCAP)

Depression | HIV/AIDS | Substance Use Disorders | Alcohol Use Disorder | Post-traumatic Stress Disorder

Zambia
Medical University of Silesia

Completed

Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD

Cannabis | Myofascial Pain | Temporomandibular Disorder | Electromyography

Poland
ANRS, Emerging Infectious Diseases
Pfizer

Completed

Efficacy and Safety of Varenicline Among HIV-infected Patients (Inter-ACTIV)

HIV Infections | Tobacco Dependence

France
Creighton University
AstraZeneca

Completed

Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety

Alcoholism | Obsessive-Compulsive Disorder | Anxiety Disorders | Generalized Anxiety Disorder | Panic Disorder | Post-Traumatic Stress Disorder

United States
Sheba Medical Center

Unknown

Hypothermia Therapy in Pediatric Cardiac Intensive Care Unit for Suspected for Brain Injury (Coolheart)

Brain Ischemia | Child | Congenital Heart Defects | Hypothermia, Induced | Hypoxia Brain
Progenity, Inc.

Completed

Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers

Hypertension | Renal Insufficiency | Proteinuria | Thrombocytopenia | Preeclampsia | Pulmonary Edema | Impaired Liver Function

United States
University of Montana

Not yet recruiting

Understanding the Role of Doulas in Supporting People With PMADs

Substance-Related Disorders | Depression | Postpartum Depression | Pregnancy | Maternal Health | Mental Health | Self Efficacy | Social Support | Delivery, Obstetric | Mental Health Services
Yale University
National Institute on Drug Abuse (NIDA)

Recruiting

Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations (ACTION)

Infectious Disease | Substance Use | Opioid Use Disorder | Substance Abuse | Risk Reduction Behavior | Stimulant Use Disorder

United States
Medical University of South Carolina
National Institute on Drug Abuse (NIDA)

Recruiting

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

Bipolar Disorder | Cannabis Use | Bipolar I Disorder | Cannabis Use Disorder, Mild | Cannabis Use Disorder, Moderate | Cannabis Use Disorder, Severe | Bipolar II Disorder | Schizoaffective Disorder, Bipolar Type

United States
University of South Florida

Unknown

Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART) (M-ART)

Stress Disorders, Post-Traumatic | Depressive Symptoms | Alcohol Abuse | Prolonged Grief Disorder | Stress Disorder, Acute

United States
NYU Langone Health
National Institute of Mental Health (NIMH)

Completed

Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) (MTA)

Substance-related Disorders | Attention Deficit Disorder With Hyperactivity | Dyssocial Behavior
Stanford University
National Institute of Mental Health (NIMH)

Completed

Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse

Alcoholism | Sexually Transmitted Diseases, Viral | Sexual Behavior | Sexual Abuse | Child Abuse, Sexual

United States
Massachusetts General Hospital

Completed

Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults

Attention Deficit Hyperactivity Disorder (ADHD) | Substance Use Disorder (SUD)
Northwestern University
Pharmacyclics LLC.

Withdrawn

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Lymphoma | Brain and Central Nervous System Tumors | Neurotoxicity
University of Virginia

Unknown

Pharmacotherapy for HIV+ Stimulant Dependent Individuals

HIV Infections | Cocaine Dependence

United States
Envita Medical Center, Inc.

Suspended

Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on Cancer

Glioma | Breast Cancer | Pancreatic Cancer | Prostate Cancer | Colon Cancer | Hepatocellular Cancer | Squamous Cell Lung Cancer

United States
Medical University of South Carolina
United States Department of Defense; Institute for Translational Neuroscience

Completed

NAC for Treating Comorbid PTSD and SUD (DoD-NAC)

Alcohol Use Disorder (AUD) | Posttraumatic Stress Disorder (PTSD) | Substance Use Disorder (SUD)

United States
CSL Behring

Completed

Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency

Emphysema | Alpha1-proteinase Inhibitor Deficiency

Australia, Russian Federation, United States, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden, Canada, Czech Republic
Grifols Therapeutics LLC

Completed

Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)

Alpha 1-Antitrypsin Deficiency

Denmark, Sweden, United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals

Lung Diseases, Obstructive | Emphysema | Alpha 1-Antitrypsin Deficiency

United States
Hacettepe University

Unknown

Turkish Version of The Measure of Processes of Care (MPOC)

Cerebral Palsy | Muscular Dystrophies | Traumatic Brain Injury | Autism Spectrum Disorder | Down Syndrome | Disability Physical | Disability, Developmental
Norwegian School of Sport Sciences
Norwegian University of Science and Technology; Sunnaas Rehabilitation Hospital and other collaborators

Recruiting

Intervention on Bone Health in Wheelchair Users (BoneWheel)

Cerebral Palsy | Amputation | Bone Loss | Spinal Cord Injuries | Spina Bifida | Dysmelia

Norway
Global Healthy Living Foundation
University of Alabama at Birmingham

Recruiting

PatientSpot Formerly Known as ArthritisPower (GHLF)

Heart Failure | Stroke | Epilepsy | Multiple Sclerosis | Obesity | Diabetes | Chronic Obstructive Pulmonary Disease | Osteoarthritis | Rheumatoid Arthritis | Parkinson Disease | Peripheral Arterial Disease | Inflammatory Bowel Diseases | Amyotrophic Lateral Sclerosis | Psoriasis | Asthma | Muscular Dystrophy | Fibromyalgia | Alzheimer... and other conditions

United States
AHS Cancer Control Alberta

Not yet recruiting

SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases

Colorectal Cancer | Liver Metastasis Colon Cancer

Canada
Sun Yat-sen University

Recruiting

Phase II Study of Regorafenib and Toripalimab Combined With RFA in Patients With CRCLM

Colorectal Cancer Liver Metastases

China
Rigshospitalet, Denmark

Recruiting

Stereotactic Body Radiation Therapy vs. Microwave Ablation for Colorectal Cancer Patients With Metastatic Disease in the Liver

Liver Metastases | Colorectal Carcinoma

Denmark
Copenhagen University Hospital at Herlev

Withdrawn

Magnetic Resonance Imaging (MRI) Using Liverspecific Oral Contrast Agent in Metastatic Colorectal Cancer Patients

Neoplasm Metastasis | Colorectal Neoplasms | Magnetic Resonance Imaging | Contrast Media | Liver

Denmark
RenJi Hospital
Shanghai 8th People's Hospital

Recruiting

Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients

Kidney Neoplasms | Fractures, Bone | Stomach Neoplasms | Prostatic Neoplasms | Urinary Bladder Neoplasms | Gynecologic Cancer | Liver Neoplasms | Rectal Neoplasms | Colonic Neoplasms | Sigmoid Neoplasms | Osteoarthropathy

China
University of California, Davis
National Multiple Sclerosis Society

Terminated

Cannabis for Spasticity in Multiple Sclerosis

Multiple Sclerosis

United States
Center for Medicinal Cannabis Research

Terminated

Cannabis for Spasticity in Multiple Sclerosis

Multiple Sclerosis

United States

Clinical Trials on Chemical and Drug Induced Liver Injury, Chronic

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