Clinical Trials on Cholestasis of Pregnancy in United Kingdom

Total 31102 results

Guy's and St Thomas' NHS Foundation Trust
King's College London

Unknown

Bile Acid Effects in Fetal Arrhythmia Study (BEATS)

Intrahepatic Cholestasis of Pregnancy | Cholestasis of Pregnancy | Obstetric Cholestasis

United Kingdom
King's College Hospital NHS Trust
European Association for the Study of the Liver

Recruiting

Liver Disease in Pregnancy

Cirrhosis, Liver | HELLP Syndrome | Intrahepatic Cholestasis of Pregnancy | Pregnancy Disease | AFLP - Acute Fatty Liver of Pregnancy

United Kingdom
Imperial College London

Completed

The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus

Gestational Diabetes Mellitus | Intrahepatic Cholestasis of Pregnancy

United Kingdom
Mirum Pharmaceuticals, Inc.

Terminated

A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA) (OHANA)

Intrahepatic Cholestasis of Pregnancy

United States, United Kingdom, New Zealand
Albireo

Completed

An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects

Primary Biliary Cirrhosis | Alagille Syndrome | Progressive Familial Intrahepatic Cholestasis | Orphan Cholestatic Liver Diseases

United Kingdom
Children's Hospital Medical Center, Cincinnati
Wuhan Union Hospital, China

Not yet recruiting

Intestinal Microbiome Composition in Infants With Biliary Atresia (BA) (BA)

Biliary Atresia | Intrahepatic Cholestases | Normal Controls

United States
Mirum Pharmaceuticals, Inc.

Active, not recruiting

MRX-800: A Long-Term Safety Study of Maralixibat in the Treatment of Cholestatic Liver Disease in Subjects Who Previously Participated in a Maralixibat Study (MERGE)

Cholestatic Liver Disease

United States, France, United Kingdom, Canada, Belgium, Poland, Australia, Spain
Mirum Pharmaceuticals, Inc.

Active, not recruiting

A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS). (RISE)

Cholestatic Liver Disease | Alagille Syndrome | Progressive Familial Intrahepatic Cholestasis

United States, United Kingdom, France, Belgium, Poland, Brazil, Mexico
University of South Florida

Completed

Omegaven as Alternative Parenteral Fat Nutrition

Cholestasis | Cholestasis of Parenteral Nutrition

United States
Indiana University

Active, not recruiting

Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical Neonates

Cholestasis of Parenteral Nutrition

United States
Baylor College of Medicine
Boston Children's Hospital

Completed

Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants

Cholestasis | Cholestasis of Parenteral Nutrition

United States
Mirum Pharmaceuticals, Inc.

Completed

Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis (INDIGO)

Progressive Familial Intrahepatic Cholestasis (PFIC)

United States, United Kingdom, Poland, France
GlaxoSmithKline

Completed

Pharmacokinetics (PKs) and Metabolism of Radiolabelled Linerixibat

Cholestasis

United Kingdom
GlaxoSmithKline

Completed

Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects

Cholestasis

United Kingdom
Light Chain Bioscience - Novimmune SA

Terminated

Primary Biliary Cirrhosis: Investigating A New Treatment Option Using NI-0801, an Anti-CXCL10 Monoclonal Antibody (PIANO)

Primary Biliary Cirrhosis

Italy, United Kingdom
Mirum Pharmaceuticals, Inc.

Active, not recruiting

An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)

Progressive Familial Intrahepatic Cholestasis (PFIC)

United States, Argentina, France, Singapore, United Kingdom, Belgium, Turkey, Austria, Brazil, Canada, Colombia, Germany, Italy, Lebanon, Mexico, Poland
Mirum Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC) (MARCH-PFIC)

Progressive Familial Intrahepatic Cholestasis (PFIC)

Italy, United States, Argentina, France, Singapore, United Kingdom, Austria, Brazil, Mexico, Lebanon, Germany, Turkey, Poland, Belgium, Canada, Colombia, Hungary
Guy's and St Thomas' NHS Foundation Trust
King's College Hospital NHS Trust

Unknown

Paternally Inherited Phenotypes in Cholestasis (PIP-C)

Primary Sclerosing Cholangitis | Cholestasis | Primary Biliary Cirrhosis

United Kingdom
University of Birmingham
University Hospital Birmingham NHS Foundation Trust; Intercept Pharmaceuticals

Terminated

EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study (EXCITED)

Primary Biliary Cholangitis

United Kingdom
Albireo

Active, not recruiting

Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFIC

Progressive Familial Intrahepatic Cholestasis

United States, Spain, Netherlands, United Kingdom, Turkey, Canada, Italy, Germany, France, Israel, Australia, Belgium, Poland, Saudi Arabia, Sweden
London North West Healthcare NHS Trust
Fresenius AG

Unknown

A Trial of Taurine Supplementation in Parenteral Nutrition 1

Cholestasis

United Kingdom
Albireo

Completed

A4250, an IBAT Inhibitor in Pediatric Cholestasis

Pediatric Cholestasis

United Kingdom, Denmark, France, Germany, Sweden
Zydus Therapeutics Inc.

Recruiting

Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease

Cirrhosis | Hepatic Impairment | Cholestatic Liver Disease

United States
Cara Therapeutics, Inc.

Terminated

Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus

Cholestatic Pruritus

United States
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University; National Institute for Health Research, United Kingdom; Department of Health, United Kingdom

Completed

B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis (RITPBC)

Fatigue | Primary Biliary Cirrhosis

United Kingdom
Albireo

Approved for marketing

Odevixibat for the Treatment of Progressive Familial Intrahepatic Cholestasis

Progressive Familial Intrahepatic Cholestasis

United States
Fast Forward Pharmaceuticals

Unknown

Pilot Study of FFP104 Dose Escalation in PBC Subjects

Primary Biliary Cirrhosis

Netherlands, United Kingdom
University of Rochester

Completed

Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis

Parenteral Nutrition Associated Cholestasis

United States
University of Alberta
GlaxoSmithKline; Axcan Pharma

Completed

Study of Combivir for Patients With Primary Biliary Cirrhosis

Primary Biliary Cirrhosis

United States, Canada, United Kingdom
SPD Development Company Limited

Completed

Consumer in Stream and Container Collected Study

Determination of Pregnancy Status

United Kingdom
Perspectum

Completed

Repeatability and Reproducibility of Quantitative MRCP

Liver Diseases | Primary Sclerosing Cholangitis | Gallstones | Primary Biliary Cirrhosis

United Kingdom
Georgetown University

Approved for marketing

Safer Parenteral Nutrition in Pediatric Short Bowel Syndrome to Decrease Liver Damage

Cholestasis of Parenteral Nutrition

United States
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus

Cholestasis, Intrahepatic

United Kingdom
University of Southern California

Completed

Randomized Trial of Wire and Sphincterotome Systems for Biliary Cannulation

Cholestasis, Extrahepatic

United States
Arthur J De Lorimier

Completed

Compassionate Use of an Intravenous Fish Oil Emulsion in Infants With Cholestasis

Parenteral Nutrition Associated Cholestasis

United States
Hector Hernandez

Approved for marketing

Expanded Access of Omegaven IV Fat Emulsion to Infants and Children With PNALD

Total Parenteral Nutrition-induced Cholestasis

United States
Sivan Kinberg

Withdrawn

Compassionate Use of Omegaven IV Fat Emulsion

Total Parenteral Nutrition-induced Cholestasis

United States
Cindy Haller

Terminated

Compassionate Use of Omegaven IV Fat Emulsion

Cholestasis | Total Parenteral Nutrition-induced Cholestasis

United States
Jeffrey Rudolph
University of Pittsburgh

Approved for marketing

Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Associated Hepatic Injury

Total Parenteral Nutrition-induced Cholestasis

United States
Rush University Medical Center

Approved for marketing

Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury

Cholestasis | Total Parenteral Nutrition-induced Cholestasis

United States
Pediatrix

Completed

Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants

Total Parenteral Nutrition-induced Cholestasis

United States
University of Oklahoma
OU Medical Center

Completed

Compassionate Use of Omegaven in Children

Infant, Premature, Diseases | Cholestasis | Gastroschisis | Intestinal Atresia | Short Bowel Syndrome | Cholestasis of Parenteral Nutrition | Total Parenteral Nutrition-induced Cholestasis

United States
Chelsea and Westminster NHS Foundation Trust
SPD Development Company Limited; Borne Charity

Recruiting

Prediction of the Onset of Term and Preterm Labour (PREDICT)

Preterm Birth | Preterm Labor | Preterm Birth Complication | Preterm Premature Rupture of Membrane | Preterm Pregnancy

United Kingdom
Boston Scientific Corporation

Completed

A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction

Cholestasis, Extrahepatic

United States
Mirum Pharmaceuticals, Inc.

Completed

An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome (ALGS) (IMAGINE)

Alagille Syndrome

United Kingdom
Mirum Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Alagille Syndrome (IMAGO)

Alagille Syndrome

United Kingdom
CymaBay Therapeutics, Inc.

Recruiting

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Hepatic Impairment | Compensated Cirrhosis | Primary Biliary Cholangitis

Korea, Republic of, United States, Spain, United Kingdom
Intercept Pharmaceuticals

Completed

Study of INT-747 as Monotherapy in Participants With Primary Biliary Cirrhosis (PBC)

Liver Cirrhosis, Biliary

United States, France, Germany, Spain, United Kingdom, Canada, Austria
Mirum Pharmaceuticals, Inc.

Withdrawn

An Open-label Study to Evaluate the Long-term Safety and Tolerability of LUM001 in Patients With Primary Biliary Cirrhosis (CASCADE)

Primary Biliary Cirrhosis

United States, United Kingdom
Imperial College London

Active, not recruiting

Hypertensive Disorders of Pregnancy - the Neonatal Burden of Disease

Hypertension in Pregnancy

United Kingdom

Clinical Trials on Cholestasis of Pregnancy in United Kingdom

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