Clinical Trials on Clinical Reasoning in United Kingdom

Total 844 results

Roswell Park Cancer Institute
Incuron

Terminated

CBL0137 in Treating Patients With Advanced Extremity Melanoma or Sarcoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Stage III Soft Tissue Sarcoma of the Trunk and... and other conditions

United States
Mayo Clinic

Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors (PNeoVCA)

Metastatic Renal Cell Carcinoma | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC v8 | Prognostic Stage III Breast Cancer AJCC v8 | Prognostic Stage IIIA Breast Cancer AJCC v8 and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

Metastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Central Nervous System

United States
Horizons International Peripheral Group
Advanced Catheter Therapies, Inc.

Completed

The COPPER-B Trial (COPPER-B)

Cardiovascular Diseases | Arterial Occlusive Diseases | Peripheral Arterial Disease | Peripheral Vascular Disease | Critical Limb Ischemia

United States
Terry L. Wahls

Active, not recruiting

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

Clinically Isolated Syndrome | Relapsing Remitting Multiple Sclerosis

United States
University of Vermont Medical Center
Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Dartmouth-Hitchcock... and other collaborators

Unknown

Comparison of Prevena Negative Pressure Incision Management System vs. Standard Dressing After Vascular Surgery

Peripheral Artery Disease | Claudication | Critical Limb Ischemia

United States
REVA Medical, Inc.

Recruiting

MOTIV BTK Randomized Controlled Trial

Critical Limb Ischemia

United States, Germany
Mayo Clinic

Recruiting

A Study of Healthy Microbiome, Healthy Mind

COVID-19 | Critical Illness | Cognitive Impairment | Dysbiosis | Mental Health Impairment | Weakness, Muscle | PICS

United States
University of Virginia
National Multiple Sclerosis Society

Unknown

Clinical Importance of Glucose Regulation in Relapsing MS

Clinically Isolated Syndrome | Relapsing Remitting Multiple Sclerosis

United States
Providence Multiple Sclerosis Center
Biogen

Completed

Safety/Effectiveness of Adding Monthly Dexamethasone to Weekly Avonex for MS

Clinically Isolated Syndrome | Relapsing-remitting Multiple Sclerosis

United States
University of California, San Francisco

Completed

Gastric Bypass After Previous Anti-reflux Surgery (RYGBafterARS)

Gastroesophageal Reflux Disease | Clinically Severe Obesity

United States
University of Pennsylvania

Completed

Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial (STAND)

Critical Illness | Acute Respiratory Failure

United States
Janssen Pharmaceutica N.V., Belgium

Completed

A Study to Evaluate the Efficacy and Safety of Sirukumab in Confirmed Severe or Critical Confirmed Coronavirus Disease (COVID)-19

Critical Confirmed Coronavirus Disease (COVID)-19

United States
University Hospitals Cleveland Medical Center
Abbott Medical Devices

Active, not recruiting

Imaging-Guided Vessel Sizing in the Tibial Arteries (iVEST)

Peripheral Artery Disease | Critical Limb Ischemia

United States
John F. Foley, MD
Genzyme, a Sanofi Company

Completed

A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis

Multiple Sclerosis | Clinically Isolated Syndrome | Secondary Progressive Multiple Sclerosis

United States
Mayo Clinic

Recruiting

A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Human Papillomavirus-Related Carcinoma | Locally Advanced Oropharyngeal Carcinoma

United States
Zimmer Biomet

No longer available

Safety and Efficacy of Autologous Concentrated Bone Marrow Aspirate for Critical Limb Ischemia - Continued Access (MOBILE-CA)

Peripheral Arterial Disease | Peripheral Vascular Diseases | Critical Limb Ischemia

United States
Michael Murphy
Zimmer Biomet

Completed

Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA) (MarrowCHAMP)

Peripheral Artery Disease | Critical Limb Ischemia | Vascular Disease

United States
Massachusetts General Hospital

Completed

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

Critical Illness | Sarcopenia | Muscle Wasting

United States
Massachusetts General Hospital
Beth Israel Deaconess Medical Center; University of Massachusetts, Worcester; Technical University of Munich and other collaborators

Unknown

Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients (mSOMS)

Critical Illness | Muscle Weakness | Respiratory Insufficiency

United States, Austria, Germany
Massachusetts General Hospital

Unknown

Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

Obstructive Sleep Apnea | Critically Ill

United States
Clinical Evaluation Research Unit at Kingston General...
Baxter Healthcare Corporation

Terminated

Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP) (TOP-UP)

Critical Illness | Acute Respiratory Failure

United States, Canada, Belgium, France
M.D. Anderson Cancer Center

Recruiting

Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Clinical Stage III Cutaneous Melanoma AJCC v8 and other conditions

United States
Mayo Clinic
Centers for Medicare and Medicaid Services

Completed

Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE) (AWARE)

Sepsis | Shock | Critical Illness | Respiratory Failure | Bleeding | Trauma | Coma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Nutritional Supplementation in Reducing Complications in Patients With Locally Advanced Esophageal Cancer Undergoing Chemotherapy, Radiation Therapy, and/or Surgery

Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Pathologic Stage IIIA Esophageal Adenocarcinoma... and other conditions

United States
Yale University
University Hospitals Cleveland Medical Center; Shockwave Medical, Inc.

Recruiting

CRUSH PAD: Real-world Outcomes Following Use of the Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

Peripheral Arterial Disease | Claudication | Critical Limb Ischemia | Femoral Arterial Calcification

United States
Tampa Bay Uveitis Center, LLC
Mallinckrodt

Completed

Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients

Uveitis | Posterior Uveitis | Intermediate Uveitis | Anterior Uveitis | Scleritis | Clinically Significant Macular Edema

United States
Boston Medical Center
Abbott; Vascular & Endovascular Surgery Society

Recruiting

Nutrition in Patient With Critical Limb Ischemia (NutriVasc)

Malnutrition | Critical Limb Ischemia | Nutritional Supplements

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma

Advanced Merkel Cell Carcinoma | Metastatic Merkel Cell Carcinoma | Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 | Pathologic Stage IIIA Cutaneous Merkel... and other conditions

United States
Edwards Lifesciences

Completed

THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial (PARTNER)

Critical Aortic Stenosis

United States, Canada, Germany
Mt. Sinai Medical Center, Miami

Recruiting

Trial to Assess Chelation Therapy in Critical Limb Ischemia (TACT3a)

Diabetes | Critical Limb Ischemia

United States
University of Colorado, Denver

Completed

Treatment of Critical Illness Polyneuromyopathy (Do-It-Now)

Acute Respiratory Failure

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Stage III Uterine Corpus Cancer AJCC v8 | Stage IV Uterine Corpus Cancer AJCC v8 | Metastatic Malignant Solid Neoplasm | Clinical Stage... and other conditions

United States
National Cancer Institute (NCI)
NRG Oncology

Suspended

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

Oropharyngeal Squamous Cell Carcinoma | Squamous Cell Carcinoma | Basaloid Squamous Cell Carcinoma | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Papillary Squamous Cell Carcinoma | Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC... and other conditions

United States, Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

Metastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain

United States
M.D. Anderson Cancer Center

Recruiting

Immune Related Toxicity and Symptom Burden in Chronic Cancer Survivors With Melanoma Receiving Adjuvant Immunotherapy With Immune Checkpoint Inhibitors

Clinical Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Pathologic Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIA Cutaneous Melanoma... and other conditions

United States
Galera Therapeutics, Inc.

Terminated

A Trial of GC4419 in Patients With Critical Illness Due to COVID-19

Covid19 | SARS-CoV-2 Infection

United States
Yale University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle (ReAlign-ICU)

Critical Illness | Sleep Deprivation | Circadian Rhythm Sleep Disorder, Unspecified

United States
Sunnybrook Health Sciences Centre

Completed

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE)

Sepsis | Mortality | Bacteremia | Critically Ill | Intensive Care | Antimicrobial

New Zealand, United States, Canada, Australia, Switzerland, Saudi Arabia, Israel
The University of Texas Medical Branch, Galveston

Completed

Detection of Clinically Significant Prostate Cancer Using Transperineal Targeted Biopsy Compared to Standard Transrectal Biopsy

Prostate Cancer | Magnetic Resonance Imaging | Target Lesion | Fusion Biopsy | Clinically Significant Prostate Cancer | Transperineal

United States
University of Pennsylvania
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood (RESTORE-cog)

Intellectual Disability | Perceptual Disorders | Memory Disorders

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI); Pfizer

Recruiting

Goal-Directed Sedation in Mechanically Ventilated Infants and Children (mini-MENDS)

Delirium | Critical Illness | Post Traumatic Stress Disorder | Executive Dysfunction | Sedation Complication

United States
University of Southern California
National Cancer Institute (NCI)

Recruiting

7T MRI Scan for the Early Detection of Melanoma Brain Metastases

Metastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain

United States
University of Chicago

Active, not recruiting

Long Term Outcomes of Patients With COVID-19 (COVID19 LTFU)

Covid-19 | Critical Illness | Respiratory Failure | Corona Virus Infection

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Prognostic Stage IIIC Breast Cancer AJCC v8 | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Locally Advanced Malignant Solid Neoplasm | Locally... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Hypopharyngeal Carcinoma AJCC v8 | Stage III Laryngeal Cancer AJCC v8 | Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IV Hypopharyngeal Carcinoma AJCC v8 | Stage IV Laryngeal Cancer... and other conditions

United States
University of Wisconsin, Madison
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

A Study of Communication Between Clinicians, Patients, and Families in the Intensive Care Unit (ICU) (TIME)

Communication | Palliative Care | Critical Care | Acute Respiratory Failure | Mechanical Ventilation | Decision Making | Life-Supporting Treatments

United States
Johns Hopkins University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children (PICU Up!)

Critical Illness | Child | Intensive Care Unit Acquired Weakness | Hospital Acquired Pressure Ulcer

United States
Washington University School of Medicine

Suspended

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

Diabetes Mellitus | Peripheral Arterial Disease | Critical Limb Ischemia | Lower Limb Amputation Knee

United States
BioGenCell Ltd.
Rabin Medical Center; Laniado Hospital

Recruiting

BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI) (EnEPC-CLI)

Peripheral Arterial Disease | Peripheral Vascular Disease | Critical Limb Ischemia

United States, Israel

Clinical Trials on Clinical Reasoning in United Kingdom

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