Clinical Trials on Craniofacial Abnormalities in Japan

Total 556 results

BioMarin Pharmaceutical

Active, not recruiting

An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia

Achondroplasia

United States, Australia, Japan, United Kingdom
Translational Research Center for Medical Innovation...
Osaka University Graduate School of Medicine

Completed

Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP)

Hypophosphatasia

Japan
Novo Nordisk A/S

Completed

A Trial to Evaluate the Safety of Once Weekly Dosing of Somapacitan (NNC0195-0092) and Daily Norditropin® FlexPro® for 52 Weeks in Previously Human Growth Hormone Treated Japanese Adults With Growth Hormone Deficiency

Growth Hormone Disorder | Adult Growth Hormone Deficiency

Japan
Pfizer

Terminated

A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia

Achondroplasia

Belgium, United States, Japan, Australia, Portugal, Denmark, Italy, Spain
BioMarin Pharmaceutical

Completed

A Multicenter, Multinational Clinical Assessment Study for Pediatric Patients With Achondroplasia

Achondroplasia

United States, Australia, United Kingdom, Japan, Spain, Turkey
Abbott Medical Devices

Completed

Absorb GT1 Japan PMS

Myocardial Ischemia | Coronary Artery Disease | Angina Pectoris | Ischemic Heart Disease | Coronary Artery Occlusion

Japan
St. Justine's Hospital
University of Maryland, College Park; Tokyo Women's Medical University; Tokyo... and other collaborators

Enrolling by invitation

The Medical Management in Patients Exposed to Weapons of Mass Destruction (CBRNEObs)

Acute Respiratory Distress Syndrome | Medical Emergencies | Distress Respiratory Syndrome | Chemical Injury | Chemicals; Intoxication

Canada, France, Japan, United States
Genzyme, a Sanofi Company

Terminated

A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients (STAGED-PKD)

Polycystic Kidney, Autosomal Dominant

Belgium, Germany, Czechia, United States, Italy, Poland, Argentina, Australia, Austria, Canada, China, Denmark, France, Israel, Japan, Korea, Republic of, Netherlands, Portugal, Romania, Spain, Taiwan, Turkey, United Kingdom
Novo Nordisk A/S

Enrolling by invitation

Post-marketing Surveillance (Use Result Surveillance) With Refixia®

Haemophilia B

Japan, Denmark
Baxalta now part of Shire

Completed

Recombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimen

Hemophilia A | Hemophilia B

Japan, Russian Federation, Spain, United States, Poland, Romania, Serbia, Taiwan, Ukraine
Genzyme, a Sanofi Company

Active, not recruiting

A Study to Assess Safety and Efficacy of Avalglucosidase Alfa Administered Every Other Week in Pediatric Patients With Infantile-onset Pompe Disease Previously Treated With Alglucosidase Alfa (Mini-COMET)

Glycogen Storage Disease Type II-Pompe's Disease

United States, France, Japan, Taiwan, United Kingdom
Mylan Inc.

Completed

Special Investigation of LipaCreon on Long-term Use in Patients With Pancreatic Exocrine Insufficiency

Digestive System Diseases | Pancreatic Diseases | Exocrine Pancreatic Insufficiency

Japan
Zimmer Biomet

Recruiting

Zimmer Biomet Shoulder Arthroplasty PMCF

Shoulder Injuries | Shoulder Pain | Shoulder Fractures | Shoulder Osteoarthritis | Shoulder Arthritis | Shoulder Deformity

United States, Japan, New Zealand
Abbott Medical Devices

Completed

St.Jude Medical Cardiac Lead Assessment Study (CLAS)

Externalized Conductors | Visual Lead Anomalies | Electrical Dysfunction

United States, Japan, Canada
Bayer

Terminated

Multiple Escalating Dose Study of BAY1093884 in Adults With Hemophilia A or B With or Without Inhibitors

Hemophilia A and B

Australia, United Kingdom, Taiwan, Japan, Korea, Republic of, Austria, Bulgaria, Hungary, Italy, France, New Zealand
Chugai Pharmaceutical

Not yet recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Antiphospholipid Syndrome (APS) | Immune Thrombocytopenia (ITP) | Dermatomyositis (DM) | Bullous Pemphigoid (BP) | Behçet's Syndrome (BS) | Immune-mediated Necrotizing Myopathy (IMNM)

United States, Japan
Alexion Pharmaceuticals

Completed

Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Spain, Australia, United Kingdom, Italy, France, Canada, Germany, Japan, Russian Federation, Saudi Arabia, Turkey
Shire
Takeda

Completed

FIRAZYR General Drug Use-Results Survey (Japan)

Hereditary Angioedema (HAE)

Japan
Sanofi
Regeneron Pharmaceuticals

Completed

Dupilumab in Japanese Patients With Atopic Dermatitis

Atopic Dermatitis

Japan
University Hospital Padova

Completed

Adrenal Vein Sampling International Study (AVIS Study) (AVIS)

Hyperaldosteronism

United States, Taiwan, Canada, Germany, Australia, Czech Republic, France, Italy, Japan, Netherlands
R-Tech Ueno, Ltd.

Terminated

Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa

Retinitis Pigmentosa

Japan
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

Tolvaptan Phase 3 Efficacy and Safety Study in Autosomal Dominant Polycystic Kidney Disease (ADPKD) (TEMPO3:4)

Polycystic Kidney Disease, Autosomal Dominant

United States, Belgium, United Kingdom, Russian Federation, France, Australia, Netherlands, Italy, Japan, Denmark, Romania, Poland, Canada, Argentina, Germany
AstraZeneca
Merck Sharp & Dohme LLC

Active, not recruiting

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN (SPRINKLE)

Neurofibromatosis Type 1

United States, Spain, Germany, Netherlands, Russian Federation, Italy, Japan
Reata, a wholly owned subsidiary of Biogen

Completed

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL (CARDINAL)

Alport Syndrome

United States, United Kingdom, Japan, Australia, France, Germany, Puerto Rico, Spain
BioMarin Pharmaceutical

Active, not recruiting

An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia

Achondroplasia

United States, Australia, Germany, Spain, United Kingdom, Japan, Turkey
Boehringer Ingelheim

Completed

A Study in Patients With Atopic Eczema to Test How Effective BI 655130 is and How Well it is Tolerated

Dermatitis, Atopic

United States, Japan, Canada
Newcastle-upon-Tyne Hospitals NHS Trust
Jain Foundation

Active, not recruiting

Clinical Outcome Study for Dysferlinopathy (Jain COS)

Dysferlinopathy | LGMD2B Now Classified as LGMDR2 | Miyoshi Myopathy

Korea, Republic of, Chile, Spain, United States, Denmark, France, Italy, Japan, United Kingdom
BioMarin Pharmaceutical

Completed

A Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia

Achondroplasia

United States, Australia, Germany, Spain, United Kingdom, Japan, Turkey
Reata, a wholly owned subsidiary of Biogen

Terminated

A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON (FALCON)

Autosomal Dominant Polycystic Kidney | ADPKD

United States, Spain, United Kingdom, Australia, France, Japan, Germany, Belgium, Czechia, Italy
Baxalta now part of Shire

Completed

Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients

Hemophilia B

Poland, United Kingdom, Spain, Bulgaria, Romania, Japan, Russian Federation, Brazil, Chile, Sweden, Colombia, Ukraine, Argentina, Czechia
Baxalta now part of Shire

Completed

Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a High Titer Inhibitor

Hemophilia A | Hemophilia B | Hemophilia A or B With Inhibitors

Poland, United States, Bulgaria, Romania, Japan, Russian Federation, New Zealand, Croatia, Ukraine, Brazil
Novartis Pharmaceuticals

Active, not recruiting

DFF332 as a Single Agent and in Combination With Everolimus & Immuno-Oncology Agents in Advanced/Relapsed Renal Cancer & Other Malignancies

Carcinoma, Renal Cell

Spain, Singapore, Czechia, Italy, Japan, France, United States
Ionis Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)

Alexander Disease

United States, United Kingdom, Australia, Canada, Israel, Italy, Japan, Netherlands
Bayer

Active, not recruiting

Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A (HEM-POWR)

Hemophilia A

Canada, Japan, Spain, United States, Germany, Sweden, Belgium, Brazil, Greece, Italy, Netherlands, Taiwan, Denmark, Kuwait, Saudi Arabia, United Arab Emirates, Norway, Colombia, Switzerland, Slovenia
Novartis Pharmaceuticals

Active, not recruiting

Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Risdiplam (STRENGTH)

Spinal Muscular Atrophy

Japan, Belgium, Spain, Canada, United States, Australia, Italy, France, Netherlands
PTC Therapeutics

Enrolling by invitation

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Inherited Mitochondrial Disease

United States, France, Spain, United Kingdom, Italy, Poland, Japan
LEO Pharma

Completed

Tralokinumab in Combination With Topical Corticosteroids in Japanese Subjects With Moderate-to-severe Atopic Dermatitis (ECZTRA 8)

Atopic Dermatitis

Japan
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)

Hypercholesterolemia

Japan
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

Recruiting

Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function (PHYOX8)

Primary Hyperoxaluria Type 3 | Primary Hyperoxaluria Type 2 | Primary Hyperoxaluria Type 1 | Primary Hyperoxaluria

United States, Canada, Lebanon, Turkey, United Kingdom, Germany, Italy, Japan, Poland, Spain, United Arab Emirates
Alexion Pharmaceuticals, Inc.

Recruiting

Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa (CHESTNUT)

Hypophosphatasia

Australia, United States, Japan, Turkey, Germany, Italy, India, France, United Kingdom, Argentina, Canada
Eisai Co., Ltd.

Completed

A Long Term Extension Study of E2080 in Lennox-Gastaut Patients

Lennox-Gastaut Syndrome

Japan
Origin Biosciences

Completed

A Natural History Study of Molybdenum Cofactor and Isolated Sulfite Oxidase Deficiencies

Molybdenum Cofactor Deficiency | Isolated Sulfite Oxidase Deficiency

Spain, Israel, United States, United Kingdom, Canada, Netherlands, Germany, Saudi Arabia, Tunisia, Japan, Italy, Malaysia, Poland, Turkey
CSL Behring

Completed

A Safety and Efficacy Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia B

Hemophilia B

United States, Japan, Israel, Austria, Bulgaria, France, Germany, Italy, Russian Federation, Spain
Novo Nordisk A/S

Completed

Safety and Pharmacokinetics of NNC 0129-0000-1003 in Subjects With Haemophilia A (pathfinder™1)

Congenital Bleeding Disorder | Haemophilia A

United States, Germany, Switzerland, United Kingdom, Italy, Japan, Turkey
Genzyme, a Sanofi Company

Completed

A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prophylaxis (ATLAS-PPX)

Hemophilia

United States, Australia, China, Denmark, France, Ireland, Israel, Italy, Japan, Korea, Republic of, Malaysia, Turkey, Ukraine, United Kingdom, Mexico
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects With Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

United States, Canada, Germany, Japan
Novartis Pharmaceuticals

Recruiting

A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors

Mesothelioma

Australia, Switzerland, Italy, Spain, Canada, Germany, Japan, United Kingdom, Netherlands, United States, France
Novo Nordisk A/S

Completed

Safety, Tolerability, and Pharmacokinetics Study of Turoctocog Alfa Pegol Injected Under the Skin in Patients With Haemophilia A (alleviate 1)

Congenital Bleeding Disorder | Haemophilia A

United States, Austria, Serbia, Germany, Japan, France
Novo Nordisk A/S

Completed

Safety of 40K Pegylated Recombinant Factor IX in Non-Bleeding Patients With Haemophilia B

Congenital Bleeding Disorder | Haemophilia B

United States, Sweden, Spain, Germany, United Kingdom, Denmark, France, Japan
Pfizer

Completed

Crisaborole for Chinese and Japanese Subjects (≥2 Years of Age) With Mild to Moderate Atopic Dermatitis

Atopic Dermatitis

China, Japan, Korea, Republic of

Clinical Trials on Craniofacial Abnormalities in Japan

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